Member Info for JoeyDiamond

That paper is supportive of using both IFN + GCs together as it gives better outcomes than just using GC alone or Interferon alone. This paper was shared a year ago as evidence that Sprinter (for secondary endpoints at least) we should see an improvement to mortality than just using Dex alone. The paper was sent to SNG.

The conclusion of the paper is similar to the trend in secondary endpoints in Sprinter trial so is supportive. Sadly not enough patient numbers in the Sprinter trial could show a statistically significant result.

Yes Doc83 we get don't get the chance to see this through to the end is my biggest worry.

Getting rid of RM and other current board members as suggested by some is the end for PI's.

Very interesting we have a number of posters bashing the company repeatedly, no doubt being paid to do so.

There is a 2 fold strategy.

1) Suppress SP /free up shares from PI's as Polygon increase position.

2) More importantly all this talk of replacing the CEO with a Polygon friendly CEO. Be very careful what you wish for. Give control over to a big fund and watch there be huge dilution and a delisting from AIM. PI's will find it very difficult to keep their shares as Polygon pretty much take over the company.

I think these posters have given away the motives of Polygon and sadly for us PI's they are not our friends.

Interesting 902k volume it’s almost as if there was a 900k buyer from USA today. But guys on this forum say it’s a sell ;)

Yep type 3 interferon proven to be the best drug in the outpatient setting so far.

https://mobile.twitter.com/boulware_dr/status/1504867085301780501.

x1 injection when given within 7 days of symptom onset reduced #COVID19 ER visits or hospitalizations by 50% in
@TogetherTrial
(n=1936) in a majority vaccinated population: 5.6% ->2.7% (P=0.001)
Hospitalization alone 4% -> 2.3% (P=0.016)
80% reduction in mortality

RNS confirms what we already knew from 3 weeks ago. Activ-2 announced they were halting recruitment due to trial design and Omicron. For drugs like SAB they were dropped. SNG as confirmed by RNS are in discussions about a finding a new outpatient trial.

Yesterday another drug S-217623 was enrolled on a newly designed trial activ-2d for outpatients. This is an NIH sponsored trial against placebo in outpatients with a high risk. The trial has sites across the world and not just USA.

So activ-2 is continuing but in a different form so there may well be an activ2-e trial.

SAB have been dropped completely but for SNG they are looking for a new trial

Prof Fish was selectively quoted in that article, for people interested she has been involved with a P3 trial of interferon ß-1a. We are looking forward to her results.

More info here.

https://pubmed.ncbi.nlm.nih.gov/34388972/

https://clinicaltrials.gov/ct2/show/NCT04552379

A5401 is another name for Activ-2.

The good news is 'starting soon' implies the comparator and protocol issues are now resolved.

One thing for certain is the results are imminent.

https://twitter.com/VPrasadMDMPH/status/1475145220618526729

https://twitter.com/TracyBethHoeg/status/1475160169076047872

Looks like a big news story developing on the vaccines. Data from Oxford reserach.

For Men <40
Pfizer D2 & D3
Moderna D1 & D2
Have rates of myocarditis GREATER than after sars-cov-2 infection.

I do know of John Campbell, however I did not know he is also suggesting the same potential vaccine administration issue. There have been other scientists and clinical staff raising this issue from as far back as 8 months ago.

We have to remember the mass vaccination drive is not being performed by just experienced medically trained nurses and doctors. There are 50,000 or so 'jabs volunteers' from other walks of like doing these jabs after a short training course. Obviously having non medical staff doing the vaccinations even with some training brings about some level of risk. The risk of individual incorrect administration is deemed less than whats gained from speed of rollout of vaccines. Without these volunteers we could never achieve the 'million a day' boosters wanted by Boris.

I disagree with you Andybe4 as to the claim you cant hit a blood vessel, it is rare granted but possible. Years ago it was standard practice to aspirate the needle to check for this very issue, however modern practice they no longer do this. Even to this day the discussion on wether to aspirate or not is not settled. Fairly recently there was a large study into this very topic looking at techniques and guidance from around the world.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333604/

A quick google search shows there have been a number of studies/news stories on the possible issue of wrong technique contributing to side effects - one example here says not to pinch the skin.

https://timesofindia.indiatimes.com/india/wrong-injection-technique-could-also-be-leading-to-clots/articleshow/84083753.cms

Im likely wont be investigated further anyway as potentially discovering a negative vaccine effect will not be good for confidence in the vaccination program.

My personal theory is the increased heart rate issues are in part due to the incorrect administration of vaccines by inexperienced staff. Normally the MRNA vaccines are injected into the shoulder muscle and any excess mrna / spike proteins are removed by the lympth nodes. If the injection misses the 'target' and instead the mrna gets into the blood stream it will travel to the heart where the spikes created will do damage. This damage can weaken heart muscle or leave scarring according to some texts ive read. For most people this may not be much of a issue but in an athlete pushing their hearts to the limits of peak performance it may explain why we see so many reports of footballers collapsing etc.

Meanwhile Israel are doing dose 4 as 3 doses no longer enough…

The vaccine 3 dose in UK will give at best 2 months good protection before antibody levels wane.

To be fair to Sotrovimab its the only mAb treatment left that works vs Omicron so will be in demand. Others like Regeneron, Eli Lilly and Celltrion do not neutralize the Omicron variant.

The downside is it needs to be delivered by IV. With an NHS on the verge of collapse I can't see many getting the chance at this drug which is a shame as it works well (for now)

The other alternative is Molnupirivir which is a mutagenic drug and likely has near zero efficacy vs Omicron. Anyone who takes that drug must be mad.

Breathlessness symptoms are not directly proportional to oxygen saturation. You could have 90% sat levels but you may not be breathless for example.

In fact the home trial data and presentation pointed this fact out. Hence why they picked breathlessness symptom as a marker as opposed to using oxygen sats.

Basically you need to have a prior infection for neutralisation so you are relying on natural immunity to a large degree. Point of the vaccines is to prevent infection and severe disease in the first place. For double dose naive individuals who are meant to be protected by the vaccines there are now big question marks.

As we learn more of Omicron vaccine escape in coming weeks it will be perfect ting for SNG vitro results on Omicron.

Very preliminary data so numbers subject to change but experiments with live omicron virus show 40 fold reduction in effectiveness of Pfizer vaccine.

There is a very large drop in neutralization of Omicron by BNT162b2 relative to ancestral virus

https://twitter.com/_b_meyer/status/1468319835012673549

I hope SNG take the opportunity to make the suggestion it works vs Omicron as IFN-B is variant agnostic.

We know interferon works vs Alpha Beta Delta and Gamma variants so we should push the message it will work for Omicron.

Andybe4 is truly an idiot. The comments from Prof Fish are factual, the obvious positives mentioned are well documented and the known concerns are understood by well researched investors here. Hence why there is a P3 trial to find this out.

The reddit board has contact with Prof Fish who is a polite and friendly person who provides us updates on her work. Like Prof Holgate is an expert in interferons and a very well respected scientist. The notion she is against SNG or her lifes works over is just ridiculous. In fact Prof Fish and SNG team known each other.

Unknown to many here Prof Fish has recently completed her own P3 trial of interferon Beta for Covid in addition to providing expertise for Betterlifes Interferon Alpha drug currently in P2.

Please LTHs ignore the utter gash written here.