Charles Jillings, CEO of Utilico, energized by strong economic momentum across Latin America. Watch the video here.
Woodstock1970 not a far out theory by any means.
Its common in labs who want to design a vaccine to use an attenuated virus. If the virus origins were from the result of Wuhan lab leak then it is very possible we are seeing SARS-COV-2 over time deattenuating to its original more potent form. May be why we are seeing worsening variants?
Knowing the origins of the virus is so important in knowing how to adequately plan for the future. Sadly all we have is theories still 19 months later ;/
They are talking about vaccines as opposed to therapies. However in relation to SARS-COV-2 then if these new nasal vaccines were released then it would have an impact on SNG001 as simply less people would get sick. In fact I would recommend investing in any company that has good results in producing nasal mucosal vaccines as they will replace or at least work alongside current vaccines. There will be another biontech / Moderna unicorn company in the making.
The current 1st generation vaccines are delivered via IM route and they have very little efficacy in preventing infection/spread as they don't target upper airways where initial infection occurs. Real world data out of Israel, Chile, Iceland for example shows between 0% and 39% efficacy. Protection vs severe disease/death is still high as they generate high titers of IgG antibodies as the disease progresses. Obviously vaccines that are not adequate in preventing infection/spread in vaccinated people this means herd immunity could never be achieved and makes the idea of vaccine passports ridiculous. Hence why UK govt I suspect is letting the virus rip to get herd immunity via natural infection.
The 2nd generation vaccines need to be delivered nasally via the nose to hit the mucosal layers. Vaccines that can generate an Immunoglobulin A (IgA) response in the nose and upper airways will have very high prevention of infection/spread. (Immunoglobulin A (IgA) is the first line of defence in the resistance against infection). The IM delivered vaccines do not have the ability to generate these protective responses simply as they delivered into the shoulder muscle.
Many of us said nasal vaccines should have been the focus of Warp Speed but they are harder to design/create whereas the 1st gen vaccines were more likely to be successful and profitable. Hence the world is where we are with the current cop of vaccines
Eric Topol was tweeting about this yesterday on the need for nasal vaccines - good diagram/thread here
https://twitter.com/EricTopol/status/1419503489546219520/photo/1
https://twitter.com/rzioni/status/1415257054818754562/photo/1
The Israeli data is not showing much in the way of preventing infection/spread. Similar results were also noted in the recent Chile study showing that 1 dose people actually had an increased risk of getting Covid. Then we see the Royal Navy having a major outbreak of Covid amongst its 100% double vaxxed crew.
As far as I can tell the UK government are not displaying this same information - Can anyone point me in the right direction to the raw data to confirm if there are similar outcomes?
NB - Don't confuse this with preventing severe covid hospitalisation/deaths efficacy - this data is looking at cases and infection.
So with this data in mind seems prudent people should still be masking / distancing etc despite government decisions as vulnerable people such as the old and immunocompromised are still going to be at risk of infection. This is one almighty gamble opening up.
https://www.gov.uk/government/publications/coronavirus-covid-19-vaccine-adverse-reactions
For UK Drs/nurses they can report adverse events/deaths via the Yellow card scheme.
An example as of 23rd June for people who took a Phizer vaccine
223404 adverse events
439 people have died
Has been much debate that many adverse events / deaths in healthy people are not being reported. Number of reasons - Medical staff to busy / Unaware of the scheme / AE's happen more than a few days in the future etc
Sadly I fear we will never know the truth about vaccine attributed deaths/AE's as recording as the data collected is very poor. Plus the placebo control groups in all the vaccine P3 trials have been abolished once the control group were given the vaccine.
Just to point out at the Euros you just need evidence of a negative LFT to gain entry to Wembley
Rules
If you need to take an NHS Lateral Flow Test
* The test needs to be taken within 48 hours of the time gates open (meaning three hours before kick-off)
* All tests will be self-administered
* The results of the Lateral Flow Tests need to be uploaded using the NHS self-report tool, whether you are a UK resident or a ticket holder from abroad.
* You must show proof of your negative test result (text message or email from NHS Test and Trace) upon entry to the stadium
* Not accepting PCR tests!
Im sure fans self testing themselves will be honest and not go the final if they get a postive test from the crappy Innova LFTs.
Every game is a super spreader event and the govt well know it.
WelshFalcon just because you don't like Fox news should not mean you just dismiss any news item from them. It is good advice to research the actual facts behind the stories. This is the problem in society people like you do not research facts and have silly allegiances to whatever your favourite news source tells you. Be that the BBC or CNN or Fox.
For someone who says 'In any case the actual origin is totally irrelevant at the moment' - That is just crazy thinking and seriously shows how clearly your misunderstanding is or how influenced you are by the 'credible' news sources you use.
Much of this information coming out from Fox news was originally researched/discovered last year by independent scientists/researchers.
The question is why are Fox only starting to report it now?
There is information posted on Reddit that is not shared on public facing forums to protect sources, that is true.
Reading the comment I believe it refers to news of P3 recruitment was progressing well. However as someone shared yesterday the SG018 trial record has been updated to show 65 sites are recruiting so its not surprising news :)
As for 'big' news not sure what it refers too. I guess people are excited about activ-2 progression potentially being close?
That can't be true Borsaci06 as many of us are in the chat room now including me lol
What big news ive not seen anything on reddit?
https://twitter.com/john_actuary/status/1410295712873656323
JCVI is recommending a 3rd booster dose of the vaccine starting in September, along with flu jabs for all over 50.
hm doesnt sound good for this Christmas either ;/
Be careful with govt figures as they not always transparent. Those numbers on that govt site exclude under 18's.
So in a way you are both correct :)
Total population numbers and adult population numbers are very different %
Yes in a short answer. Here is an article on the FDA and EMA partnership.
https://www.fda.gov/news-events/fda-voices/partnering-european-union-and-global-regulators-covid-19
SNG will be confident the drug works vs any variant. However with regards to Delta I would wait before doing the lab tests and hold the good news in reserve.
The Delta lineage will eventually become the dominant strain in the USA, UK and EU. Once all these countries have large new waves and lockdowns are on the horizon, then it would be the time to release the lab test for maximum impact.
Joker99 you seem very worried about SP rise.
'Delaying Step 4 for 5 weeks, so that it coincides with the school vacation period is expected to have a larger effect in the short term helping to flatten the summer wave and reducing the number of deaths from 49,700 (35,600-67,200) to 43,500 (31,200-62,900) and peak deaths from 700 (500-1,200) per day to 500 (300-800) for the medium / central immune escape scenario and 50% increase in transmissibility for the Delta'
This takes into consideration the step 4 delay.
As for the vaccine efficacy you are quoting its based on many assumptions, estimations and very wide confidence intervals. The efficacy is not based on absolute numbers. I suspect its been released to give a positive picture by govt. You can see the model here.
https://khub.net/web/phe-national/public-library/-/document_library/v2WsRK3ZlEig/view_file/479607329?_com_liferay_document_library_web_portlet_DLPortlet_INSTANCE_v2WsRK3ZlEig_redirect=https%3A%2F%2Fkhub.net%3A443%2Fweb%2Fphe-national%2Fpublic-library%2F-%2Fdocument_library%2Fv2WsRK3ZlEig%2Fview%2F479607266
Apologies for the editing but LSE removed it so wall of text :0
However please read the report showing what govt scientists are predicting. Optimistic case scenario 43,500 deaths in Summer wave ;/
https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/993361/S1290_LSHTM_Roadmap_Step_4.pdf
Latest on roadmap data and modelling of the India variant.
? Implementing roadmap Step 4 as planned is likely to exacerbate this and lead to a third wave of infection, peaking in August or early September 2021. Under most scenarios, this summer wave would be smaller than the January 2021 wave, in terms of hospitalisations and deaths, but comparable to the April or October 2020 waves. Under more pessimistic scenarios of high immune escape and high transmissibility of Delta B.1.617.2 (70% more than Alpha B.1.1.7), it is possible that the summer wave could exceed the January 2021 peak in terms of hospitalisation and deaths. The size of the peak depends strongly upon the levels of mobility (and hence social mixing) reached following Step 4, and accordingly changes to Step 4 policies may have a large effect on the dynamics of the summer wave.
? The model projects that more than half of the hospitalisations and deaths occurring in the summer 2021 wave will be in unvaccinated individuals, with admissions being split relatively evenly between the 45-64, 65-74 and 75+ year age groups. Deaths are likely to be concentrated in the 75+ age group.
? Delaying Step 4 of the roadmap is likely to have an impact in the short term, reducing the impact of the summer wave. A two week delay has a modest impact, reducing deaths as measured until the end of October 2021 from 49,700 (35,600-67,200) to 48,500(34,400-66,900) for the medium / central immune escape scenario and 50% increase in transmissibility for the Delta B.1.617.2 variant. Delaying Step 4 for 5 weeks, so that it coincides with the school vacation period is expected to have a larger effect in the short term helping to flatten the summer wave and reducing the number of deaths from 49,700 (35,600-67,200) to 43,500 (31,200-62,900) and peak deaths from 700 (500-1,200) per day to 500 (300-800) for the medium / central immune escape scenario and 50% increase in transmissibility for the Delta B.1.617.2 variant
? Taking further measures to reduce the summer wave, such as delaying Step 4 until all adults have had both vaccine doses, instigating a circuit-breaker lockdown or moving back to Step 2 measures is likely to largely negate the impact of the summer wave, unless pessimistic assumptions regarding immune escape and transmissibility are adopted (Tables 6 and 7 and Figures 9-12). Note, however, that the more stringent the short term measures are, then the larger the bounce-back in cases later in the year (Figures 9-12), when schools will be open and other seasonal factors are less favourable. Indeed, for these reasons even the 2 or 5 week delay to Step 4 can result in modest increases in morbidity and mortality when measured until the end of the year (Tables S3 and S4) as more cases are pushed back into the autumn.
People disappointed with no news today, here is some positive news to lighten up your weekend.
https://twitter.com/business/status/1403362899494592515
Murdoch’s Sun, U.K.’s Biggest Paper for Decades, Now Worth Zero
RScorpio it was a live 5 and 1/2 hour NIH event led by Dr Collins, I don't know of a repeat link. It was a general overview of USA trial systems by a guy called Dr Cliff Lane so was very little to take from it for SNG per se other than those few points I mentioned.