Member Info for JoeyDiamond

https://www.southamptonbrc.nihr.ac.uk/impact-case-study-v4-2/developing-new-treatments-for-respiratory-viral-infections

Interferon Beta central to plans is a positive sign

https://www.help.senate.gov/imo/media/doc/report_an_analysis_of_the_origins_of_covid-19_102722.pdf

US Senate report - some key notes

"Based on the analysis of the publicly available information, it appears reasonable to conclude that the COVID-19 pandemic was, more likely than not, the result of a research-related incident."

"Advocates of a zoonotic origin theory must provide evidence ... as was demonstrated for the 2002-2004 SARS outbreak. There needs to be verifiable evidence that a natural zoonotic spillover actually occurred, not simply that such a spillover could have occurred."

https://www.nature.com/articles/s41598-022-22307-9

We here report the ability of VitD to enhance host IFN-alpha/beta (a/ß) signaling both in vitro and among severe COVID-19 patients treated with VitD. Blood and saliva specimens were obtained from severe COVID-19 patients treated (43 patients), or not (37 patients), with vitD, during their stay in intensive care unit. Patients were followed up to 29 days following admission, and patient survival outcomes were collected. Higher activity levels of RIG-1/MDA-5 and JAK-STAT signaling pathways were observed with significantly higher gene and protein levels of antiviral interferon stimulating genes (ISGs) such as MX-1 and ISG-15; both in vitro, following treatment of PBMCs with vitD, and in whole blood and saliva specimens of VitD treated patients. Moreover, VitD treated patients had lower risk of all-cause mortality by day 29 compared to untreated patients (adjusted hazard ratio, 0.37, 95% confidence interval of 0.14–0.94; P?=?0.038). The herein uncovered regulatory role of VitD on type I IFNs suggests the importance of insuring a normal level of VitD for the prevention and probably treatment of SARS-CoV-2 infection.

Vitamin D enhances type I IFN signaling in COVID-19 patients

I think people are misunderstanding what the long Covid data is about.

https://www.gov.uk/government/publications/decision-on-evusheld-as-a-coronavirus-covid-19-treatment-letter-to-patient-groups/decision-on-evusheld-as-a-covid-19-treatment

Decision on Evusheld as a COVID-19 treatment
Published 6 October 2022

The official response which is what I agree with.

That makes it even more important then! Giving immunocompromised patients a drug that doesn't work any more is going to lead to people believing they are safe and will put them in jeopardy. SARS-COV-2 has leapt ahead in the arms race again and like many mAbs that have come before the virus has overcome.

As the news article alluded to there are 6 other drugs under trials that may be more beneficial longer term. Makes more sense to spend billions on one of these newer drugs for immunocompromised people than spend on a drug that potentially will be overcome by the virus within weeks. There isn't a limitless pot of money and the little that we had has been squandered.

Yes im anti many drugs that simply don't work vs SARS-COV-2 any more or never worked as claimed in the first place!

https://www.biorxiv.org/content/10.1101/2022.09.15.507787v3

Against the newer variants now doing the rounds Evusheld looks to be ineffective. There have been a number of papers recently like the above showing this.

https://www.statnews.com/2022/10/18/biden-scramble-covid-variants-threaten-evusheld-immunocompromised/

US and other countries are expecting the only approved treatment Evusheld in Immunocompromised people to be ineffective this winter. So much so they are looking for another drug from 6 candidates.

Giving people the belief they are' protected' with Evusheld from these new variants I believe will be a mistake. People will let their guard down and end up dying.

Not signed from me unless AZ can provide some quality data their drug still works.

https://jamanetwork.com/journals/jama/fullarticle/2797483

Findings In this double-blinded, randomized, placebo-controlled platform trial conducted in the US during a period of Delta and Omicron variant predominance, and that included 1591 adult outpatients with COVID-19, the posterior probability of improvement in time to recovery in those treated with ivermectin vs placebo had a hazard ratio of 1.07, with a posterior probability of benefit of .91. This did not meet the prespecified threshold of posterior probability greater than .95.

Meaning These findings do not support the use of ivermectin in outpatients with mild to moderate COVID-19.

Interesting attendees
Abbvie
Gritstone
Shionogi & Co

People are expecting an RNS at 8pm tonight? I think Monday would be more likely.

Thanks for the link Brand

My earlier point proven on the few trying to defend this are the ones whose reputations are on the line.

That’s the big problem there is no proper regulation in place and even well meaning scientists could cause a new pandemic.

This virus in particular had an 80% fatality rate in humanised mice. Wasn’t even conducted in a highly secure lab. Fauci / NAID has enabled / funded dangerous research without proper checks or regulation in place.

It’s utter madness. One day soon another more deadly virus will escape if regulation isnt brought in.

Indeed it is interesting the scientists following this and the ones trying to discredit.

Notably the few discrediting are the ones who are the zoonati crew, reputations are on the line here and potentially criminal proceedings to follow.

Endonuclease fingerprint indicates a synthetic origin of SARS-CoV-2

https://mobile.twitter.com/WashburneAlex/status/1583145276151189504

Big paper has dropped causing much discussion in the science world.

Polygon are more likely looking to recoup their losses, there is an assumption on the board they need to make a profit which is wrong.

Polygon may well be happy to only make a 20% loss as opposed to 80% loss and will bail when the timing is right.

I seem to remember vaccine mandates and people losing their business and jobs as one example. Hateful treatment of people not vaccinated making them 2nd class citizens denying them of access to restaurants etc. All this had an impact to the economies across the world.

The actual phizer vaccine trial results had more people die in the vaccine arm than placebo! Last records from UKHSA showed no difference in mortaility between vaxxed/unvaxxed before they were yanked from public view. So how many lives have they actually saved?

Much of the pandemic response was based on the vaccines stopping the spread of the virus. That’s what the politicians, MSM and government scientists led us to believe. Thanks to the pandemic response we now have a destroyed economy and the coming winter is going to be very difficult for many.

A few of us pointed the obvious short comings and lies out back in 2020 but as MSM told us we must be crackpot anti vaxxers. More and more information will leak out in the coming months.

Why would you take a booster if you have a prior infection with BA5?