Member Info for JoeyDiamond

There has been some nonsense posted tonight and board has well and truly disrupted/deramped. Why do people fall for it every time.

Seriously people have to question why Synairgen are not marketing SNG001? Come on lol.

We need a salesman? What do people think selling SNG001 will be similar to mobile phone sales to the public?

Commercial Awareness? Do you think huge multi million $ pre orders will appear on the say so of a small pharma with a small P2 dataset amongst competing big pharmas drugs :)

Quite simply the P3 and the data it provides is everything to Synairgen. Any commercials/sales/marketing/approvals relies on the data it provides. It really is that simple at this point.

What we know is P3 starts very soon, we are just pending final regulator approval and start date. Patients are ready to dose. If the data is looking great then good chance of EUA's will follow in due course. Patience is the key now.

Hi Tim

Here is the P3 trial design -
200 patients in the UK across 20 sites is the plan.
300 in EU across 130 sites
400 rest of world.

https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-004743-83/GB

I have been gradually building a position here over last 6 months or so, still scratch my head as to why this hasn't gone North yet of 14 :)

You look at IES as an example which doubled its value in a few weeks on the new vanadium flow batteries projects news. Vanadium projects are garnering support how long until more see the value added here in BMN?

https://twitter.com/EricTopol/status/1333409749933559810

https://www.nature.com/articles/s41593-020-00758-5

Some more studies relating to the subject for anyone interested in a long and difficult read :)

https://www.news-medical.net/news/20201117/UCLA-researchers-pinpoint-how-smoking-causes-more-severe-COVID-19-infection.aspx

https://www.standard.co.uk/news/london/london-dirty-air-increase-risk-catch-covid-b79380.html

New research from Queen Mary University shows a link between particle pollution from traffic and susceptibility to covid infection. Researchers took PM10 particulates captured in Marylebone Road and tested them on laboratory-grown human nose and throat cells. They found that these airborne pollutants increased the body’s susceptibility to contracting the virus.

This follows on from smokers being more suseptible to Covid-19. Will be interesting once cities reopen with heavy traffic will we see an increase in infections.

https://www.rdm.ox.ac.uk/people/jan-rehwinkel

Look forward to what this guys input is.

Prof Ling-Pei Ho was the NIHR lead who helped deliver the P2 trial in 2 months and will likely be invloved in P3. Listen carefully to what she says too as good snippets could come from her as well as Prof Tom.

One thing for sure is Synairgen are not part of the click ie Oxford/big pharma/govt club. Wether we like it or not big pharma has incredible lobbying power over politions and scientists.

AZN as we know got pre orders for their mAbs treatment during P2 trails from our government. For a small company like Synairgen who do not have the resources or size to influence, only a strong dataset from P3 will make governments take more notice and order SNG001.

Thats my personal opinion. I think it may be part of the reason Richard keeps saying data is king.

Yes thanks for sharing very interesting information. The long covid condition still looks to be very misunderstood but from these articles it looks to me the disease route of progression is distinctly different. People have been focusing on the lungs as route of entry but the other route of entry is via nasal/olfactory bulb and then into the brain.

I wonder what Synairgen know of this? If assumptions on these papers are correct when inhaling SNG001 it would be beneficial to have some go toward the olfactory bulb? Our P3 trial design endpoints are looking to help prevent long covid.

Thats worrying, the vaccines will likely have no effect for peoples long covid.

Yes we are all millionaires over night :)

I think these articles are pretty robust and there is credible science showing the vaccines will not prevent infection. They will just lessen severerity of disease.

People recognising the need for the potential of mucosal vaccines :)

Then you look at what the Chinese did way back in January to prevent Covid-19. Back in 2010 they developed interferon aplha nasal spray to help prevent viruses in their army population.

They used the interferon spray in all of their medical staff and not one person developed Covid-19

https://www.medrxiv.org/content/10.1101/2020.04.11.20061473v2

Still to this day its a mystery why Western countries did not develop interferon earlier when they could see from the Chinese how effective it was.

https://fas.org/expert/eric-feigl-ding/

Here is Erics bio, nothing else I need to say except you look like a prize idiot again.

https://twitter.com/DrEricDing/status/1333171614582714368

Dr Ding also talking about it.

https://twitter.com/AliNouriPhD/status/1333101128897212417
Dr Ali Nour / Molecular Biologist; President, Federation of American Scientists.

Paper - https://www.sciencedirect.com/science/article/pii/S030439402030803X

'While respiratory problems receive most attention, nearly 10-35% survivors suffer disabling, persistent neurological symptoms. Patients w/altered mental health hospitalized 3X times longer; 2/3 unable to manage daily activities at discharge. Underlying causes are complex. Low oxygen; metabolic irregularities. Inflammatory response in the brain—activation of microglia & cytotoxic T cells—and other signs of neuropathy have also been observed

/Long COVID: ~10-35% suffer persistent symptoms, mostly neurological: autonomic nervous system dysfunction, sleep disturbance, pain syndromes, dizziness, cognitive difficulties. In one series of hospitalization, 1/3 suffered memory loss post-discharge/

Some key snippets
Hospitalized 3X times longer
2/3 unable to manage daily activities at discharge.
Up to 35% suffer persistent symptoms

I hope people can see SNG001's all round utility and importance at early hospital phase. Look at the P3 trial design and the endpoints chosen. The key scientists in the USA have recognised long covid and the requirement of a drug that can help recover people quicker and back to their normal range of activities.

Shadowboxer sure it was a joke. You were called out with facts and made to look like an idiot.

5p would make market cap around £10 million. Considering they have just raised £87 million at placing makes that seem just a bit silly.

Type I Interferons Interfere with the Capacity of mRNA Lipoplex Vaccines to Elicit Cytolytic T Cell Responses

https://www.sciencedirect.com/science/article/pii/S1525001616454560

A paper looking into mrna cancer vaccine and a strong interferon response.

some snippets

Here, we demonstrate that mRNA lipoplexes induce a potent type I interferon (IFN) response upon subcutaneous, intradermal and intranodal injection. Regardless of the route of immunization applied, these type I IFNs interfered with the generation of potent cytolytic T cell responses.

As type I IFN induction appears to be inherent to the mRNA itself rather than to unique properties of the mRNA lipoplex formulation, preventing type I IFN induction and/or IFNAR signaling at the site of immunization might constitute a widely applicable strategy to improve the potency of mRNA vaccination.

Conversely, the antiviral actions of type I IFN, production of RNAses and instigation of translation arrest might interfere with the expression of the mRNA encoded antigen and therefore negatively impact T cell immunity

----
The mrna vaccine being used in Covid-19 could well have differences to this cancer vaccine so possibly the same issues do not occur. Will be interesting to see if Moderna/Phizer got round these issues and how long immunity will actually last if there is a major interferon response to the vaccine.

I am wondering if there is an ingredient in the vaccine that dampens down the bodies interferon response to make the vaccine more effective. Funnily enough a chief characteristic of what the virus is doing.

2 of the independent MHRA members are share holders in AZN should be no problem approving it )