RE: NHS COVID-19 MOBILE TEST UNITS11 Feb 2022 14:31
From an article last week about the Optigene Covid POC test (which isn't as good as Genedrive's)... great to see how enthusiastic the medical professionals are about increasing the use of POC tests in humans, similar to how they have been used by vets for years.
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"For RNA RT-LAMP on swabs, the overall diagnostic sensitivity was as high as RT-qPCR testing. This supports the use of such testing in mobile testing units, as recently undertaken for testing of individuals from overseas attending high level meetings in the UK.
For Direct RT-LAMP, the overall diagnostic sensitivity was highest (85%) on saliva samples, with a specificity of 100% when compared to standard RT-qPCR testing. In tests on saliva samples containing a high viral load, the sensitivity of the test increased to 99%. This indicates that the test is highly effective in identifying infectious cases, including from people not displaying symptoms.
The findings demonstrate that RT-LAMP is applicable to a variety of use-cases, including frequent, interval-based testing of saliva with Direct RT-LAMP from asymptomatic individuals that may otherwise be missed using symptomatic testing alone.
Dr Veronica Fowler, a virologist who specialises in molecular detection methods and pioneered the optimisation and validation of the RT-LAMP technology for COVID-testing said:
“Many of the country’s leading molecular scientists and virologists have joined together to rigorously evaluate the Optigene RT-LAMP test in a variety of settings and confirmed its high accuracy in individuals with and without symptoms. The test is particularly effective in identifying people who are at risk of transmitting the infection to others, including people not displaying symptoms. Despite the emergence of a number of highly mutated variants, including Omicron, the RT-LAMP assay continues to perform with high accuracy due to particular features of how the test was developed.
“The application of using lower cost, rapid molecular tests, such as RT-LAMP to identify and control highly infectious viral diseases has been performed in the veterinary world for years. I am pleased through this huge collaborative effort that we have succeeded in transferring this concept and practice within the human infectious disease world for the benefit of saving people’s lives.”
Professor Keith Godfrey, of the University of Southampton MRC Lifecourse Epidemiology Centre and NIHR Southampton Biomedical Research Centre, who led the community based aspects of the evaluation said:
“It is extremely helpful to have the ‘real world’ demonstration of how the RT-LAMP test can be implemented in different settings. It provides an important example of how these tests can make a valuable contribution to overall COVID-19 testing capability.”