Member Info for Ivyspivey

Ruck ATB for your daughter in law and is a reminder of the main reason why all of us want these treatments in the clinic ASAP

Nom.
Still unknown if Coronavirus 19 is Zoonotic or not.Quite a few cats/ dogs do have Coronavirus abd several Vaccines available but normally different strains

https://www.google.co.uk/url?sa=t&rct=j&q=&esrc=s&source=web&cd=1&ved=2ahUKEwi3hJys3L3nAhWASBUIHdkwAMkQFjAAegQIBBAB&url=https%3A%2F%2Fwww.hemopet.org%2Fthe-wuhan-coronavirus-and-companion-pets-2019-ncov%2F&usg=AOvVaw3Aok8QAXa-azShiPiPSJPm

What Tsbs does not know is when Coggy threatens to sort him out in Carlisle.He only gets as far as the Pencil museum at Keswick gets his H2B pencil topped up with a lead Relining so that he can give Xmas presents to the great and the good
Have to laugh at our situation or would go mad.

Part 2

At first we tried to get into the situation as much as possible and not complicate the situation. But when we realized that there would be no salary for the New Year, we decided to fight legally. We were fired on December 17 only because we demanded our salaries. The company did not make any concessions to somehow alleviate the situation, to help us at least before the holidays, ”said Iveri Tsiklauri, an employee of the company, oil production operator, in an interview with News-Georgia.
Frontera Resources Corporation, an American gas and oil exploration and production company, was founded in 1996. The company's strategy is to search for hydrocarbon production prospects in the markets of Eastern Europe, which belong to the Black Sea basin.

More stuff

TBILISI, February 6 - News-Georgia. Former employees of the American oil company Frontera Resources held a protest rally in central Tbilisi today demanding compensation for their salary arrears.

About a hundred people gathered outside the building of Tbilisi State University on Chavchavadze Avenue and staged a march to Paliashvili Street, where the company’s office is located, with the slogans “Let serfdom end”, “Up to a hundred employees were left without a salary”, “Why don't you give me a salary?”

Representatives of United Trade Unions and industry organizations joined the protesters.

I know things get lost in translation but where the heck does “ pregnant women” come in.
How long ago was Coggy on the site visit and did he leave some gifts lol

T
Translate from:Russian
Tuk Tuk! What the hell? Protest in Georgia. But there are no parliamentarians, and no American oil companies.

Frontera Resources, a non-profit company, has not started paying in full. And under the New Year she gave them a gift - a gift. There are many pregnant women and members of the profession who work hard and long after their illness. Damage to the reputation of non-profits companies.

An interesting eight American story. Congressman Brian Babin has spoken out about the problem of "Frontera" disrupting "current democratic trends in Georgia".

There is not enough democracy in your home country, you have to get rid of the American company. So what?
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Frontera Resources, ???????????? ????????????, ????? ??? ?? ?????? ???????? ???????????. ? ??? ????? ??? ??????????? ?? ??? ???? ??????? — ??????????. ?????? ?????????? ? ????? ?????????? ??????? ??????? ?? ?????? ? ????? ?? ?????????. ???? ???????? ?? ??? ???????? ? ?????????????????? ????????.

????????????? ????? ???????????? ???????. ??????????? ?????? ????? ??????, ??? ???????? ?????? "Frontera" ???????? "?????? ????? ????????? ?? ????????? ??????????????? ???????? ? ??????".

???? ? ????? ?????? ?? ??????? ??????????, ??????? ?? ???????????? ???????? ?? ?? ????????. ??? ??? ???

#Sputnik?????? — @SputnikLive

https://ift.tt/3bjd9xRThis is tweet translated New post in MindStorm: Knock Knock! Who's there? Protesters in Georgia. But now with claims not to parliament, but to the American oil company. Frontera Resources, an oil producer, has not paid salaries to employees for almost a year. And on New Year's eve ...

Quite a lot of Tweets going in about FRR employee demos traction.Will try and not release stuff and apologies if already posted but these tweets only sent in last few hours.

https://www.newsgeorgia.ge/uvolennye-sotrudniki-amerikanskoj-kompanii-frontera-resources-ustroili-akciju-v-tbilisi/

Interesting bit from Looed article.
If we recall arbitration was only mentioned as money set aside on small print off GOGC accounts which is a legal requirement.Explains possible silence but FRR have totally kept quiet which I am not sure about.

The fact that the Oil and Gas Corporation did not inform Frontera employees about the lawsuit that began, he explained by the decision of the Corporation to follow the advice of lawyers to keep everything in strictest confidence.

More feedback of Georgia FM meeting Risch and Shaheen in US. No mention of FRR or economic issues.

https://www.google.co.uk/url?sa=t&rct=j&q=&esrc=s&source=web&cd=2&ved=2ahUKEwjW_YTJmrvnAhVRiFwKHakkDN8QFjABegQIAxAB&url=https%3A%2F%2Fcivil.ge%2Farchives%2F337321&usg=AOvVaw2B5yxjmJyonpZbPKwH5WPq

With new Georgian business ombudsman yesterday and photos.Cant see any FRR.

http://www.amcham.ge/album.php?item=390

As you say does seem overkill and reminiscent of Putin parading the 2 guys accused of the Salisbury poisoning and them claiming to be tourists.
At least in this case FRR can tell the “ truth” behind closed doors to the US politicians.
If they have no ground to stand on then the US politicians will not support them and I believe that they would have got the FRR side before sending letters

https://ge.usembassy.gov/ambassador-kelly-degnans-remarks-to-media-per-meeting-parliament-speaker-talakvadze-february-3/

Sounds like positive meetings and sure FRR was discussed as Speaker had plenty to say about Congressmen letters.

After a few hours of honest toil I come back to a torrent of “ stuff” which is evidential of me and Knowlsie scoring a bullseye with our earlier posts.So what do we have.
WF saying the bar has been raised and a Inanaco saying it has not.Who do we believe well the answer is WF as any objective viewer can clearly see from Bermudas post.
Has anyone answered the question I raised about what they thought the new clinical endpoints would be.No response at all.
Inanaco seems to think SCIB 1 will compete in a vacuum populated only by other cancer vaccines.Wrong as the choice will be between all treatment options.
He says Toxicity is not an issue well KF certainly thinks it is a crucial USP for SCziB 1 and I would rather take his view.
Rats is wheeled out for a “ character assassination” well where is the proof.Show me the evidence of my posts on this or any other share where I have claimed inside info.This is complete fabrication and a lie.
I bet a few in here wish they had sold shares here after the retrace but I know it is a heinous crime except of course unless it us to put Xmas food on the table lol.
Anyway off now to do some more work but I have been cheered up on a grey day by the angry responses of some who clearly have been rattled by mine,Knowlesi and Bermuda’s earlier posts.

Thanks for reasonable response WF and as I don’t pretend to understand all of the miniature of the science I ask questions for the benefit of myself and others.
We just ask for a straight response not waffle or trying to hijack the question to divert away from the answer.
So again I ask in the light of the bar has been raised by other treatments what is a suggested clinical end point in the SCIB 1/Keytruda phase 2 trial?
If no one knows the answer then fine just admit it.
Once again WF thanks for your valued input and reasoned response

In full

Inanaco,

Regarding your 23.43 post on lse. Some valid points were made by Ivy and Knowlesi.

When the SCIB1 combination trial was announced back in 2015 there were no FDA approved PD-1 combination therapies for advanced melanoma - the field was empty. Scancell's trial aims to produce a response rate of 55%.

Over the past 4 years the field has moved on. The FDA have approved the Yervoy/Opdivo combination in melanoma which produced response rates of 58%. Combinations with chemo have been approved for H&N and lung cancer. There are literally hundreds of ongoing combination trials and some have produced promising results.

Over the period there has been a subtle change in Keith Flaherty's language which reflects the changing landscape of combination therapies. Back in 2015 it was all about the need for an effective combinations because there were none. Yesterday he acknowledged that existing combinations had already improved outcomes but stressed the need is for combinations that don't add to toxicity.

This seems entirely reasonable and logical and actually plays to Scancell's strengths - possibly the biggest single advantage of SCIB1 is the lack of toxicity. There will be very few combination therapies out there able to match the safety profile of SCIB1. So if Scancell are able to match response rates they have an advantage on cost and toxicity.

You asked for examples - here's one from MD Anderson, PD-1 + BRAF + MEK inhibitors - response rate 71.8%

Https://www.mdanderson.org/publications/cancer-frontline/triple-combination-shows-promise-against-advanced-melanoma.h00-159303834.html

There are others and will be many more. So the posts were correct, the bar has moved over the last 4 years, there's no point in denying it and it would be astonishing if it hadn't. It's not a negative, it's just how it is and we're fortunate that subject to results SCIB1 should still be able to compete on its own merits.

Hi WF
In the spirit of wanting to help I will post Bermuda’s post on ADVFN which probably gives the best précis on the matter.

https://uk.advfn.com/cmn/fbb/thread.php3?id=28007005

How come when ever you ask a reasonable question many folk respond with another question rather than answering your question.
Is it because they don’t know the answer or deliberately seek to divert attention away from the question they are asked.