Member Info for inanaco

do you just make this stuff up ............. ?

Ivy ... "" I dont need to be a fund manager to follow the evidence""

lol ......... CD4 as presented to day ... contains Third party evidence ..

ATB

is the "alternative view" ......... just to ignore that ??

your posts come across as thou Funding is impossible ....

Ivy you can challenge the mouse with Live Virus ...

can you show the T cell response from a vaccinated patient who has responded with a t cell response against a live virus challenge

"""Showing a T cell response in a mouse on Sky does not compare with evidence in the public domain generated by other Covid 19 Vax candidates ATM hence more interest in them than here."""

ATB Ivy ...

Kat ...

but they are paying Kat ........ they are collaborating .. ie it has a cost ....

if they don't license the IP that input has help Scancell identify problems at no cost

its gone cloudy ..

are you coming here to cause Trouble Ivy ............ ? looks like it to me, didn't you attempt this the other day .. ? By pretending to be a Fund Manager ...

and actually they have ........ Lindy has a T cell killing a virus .. on screen Sky News ...

""" Well SCLP have not provided any evidence for activating""

can you show a Post Ivy, that i have dismissed a particular Covid vaccine .... ?

I am trying to explain the importance of a CD4 t cell to any vaccine .........

you are clearly not getting that importance

I was going to expand the thread to the differential for CD4 helper into TH1 and Th2 " and the way they interact with humoral response (antibodies)and Cell mediated Cd8 T cells

i ask you a question and you reply with a question ... while dismissing my question with "whats the point"

as this is going no where ATB

in your opinion ............ Bermuda ... who is the most advanced vaccine designer of CD4 t cells ... ??

Who has proven they can build a vaccine that induces Cross presentation to induce potent High Avidity T cells

its all about the platform ........

Viral pathogens often induce strong effector CD4+ T cell responses that are best known for their ability to help B cell and CD8+ T cell responses. However, recent studies have uncovered additional roles for CD4+ T cells, some of which are independent of other lymphocytes, and have described previously unappreciated functions for memory CD4+ T cells in immunity to viruses. Here, we review the full range of antiviral functions of CD4+ T cells, discussing the activities of these cells in helping other lymphocytes and in inducing innate immune responses, as well as their direct antiviral roles. We suggest that all of these functions of CD4+ T cells are integrated to provide highly effective immune protection against viral pathogens.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764486/

""indispensable""

which is why Oxford hailing T cell success .... is a bit strange ..

https://www.nature.com/articles/s41417-020-0183-x/figures/2

on the right hand side you will see ... antibody affinity maturation and class switching ...

CD4+ T cells are also indispensable for the induction of humoral responses against tumour antigens by providing help via CD40 ligand signalling to CD40 on B cells to drive their differentiation and maturation into affinity-matured, class-switched plasma cells. Their activity correlates with the presence of serum antibodies specific to tumour antigens [17, 128], and they likely play a role in driving local antibody responses in tertiary lymphoid structures [129] adjacent to solid tumours.

just replace "tumour antigens" with "Viral antigens"....

the Roche .. BioNtech trial is so revealing .......... they had immune activation !!
but that response was poor ......... so a "personal vaccine" plus a Checkpoint .... failed despite eliciting an immune response

and this is the problem when you only look at "immune response" ..... Inovio always did the same it announced fantastic T cell numbers .... however run through the products that it has scrapped ... or Big Pharma have walked away from .. and those responses hide the truth ..

which is why I caveat my posts on moditope Ovarian Cancer with

Waiting for Efficacy ...

but what i can do with SCIB1 ... is declare Efficacy .... we already know it works .. in the adjuvant and against solid tumor
Lung Mets disappeared ... can we now remove one of the defense arms of cancer with Keytruda .. ?

waiting efficacy ...

""" However the source cautioned that the results, while “extremely promising”, did not yet prove that the Oxford vaccine provides long-lasting immunity against Covid-19."""

and that is it in a nutshell ........

unknown over 55's
unknown those that have other chronic conditions

until you get that detail ......... the vaccine is worthless ..

I said this from the very start ............ the 80% don't matter ... its the 20% that get into trouble

exactly the same with the Flu .. the Government does not inoculate the whole population

People who should have a flu vaccine
The injected flu vaccine is offered free of charge on the NHS to people who are at risk.

This is to help protect them against catching flu and developing serious complications.

You should have the flu vaccine if you:

are 65 years old or over
are pregnant
have certain medical conditions
are living in a long-stay residential care home or another long-stay care facility
receive a carer's allowance, or you're the main carer for an elderly or disabled person whose welfare may be at risk if you fall ill
Frontline health and social care workers are also eligible to receive the flu vaccine. It's your employer's responsibility to arrange and pay for this vaccine.

yummy with a double flake ..

Nice Route that 66 Ruck ...

Dick has had his posts removed ... he must be sailing a bit to close to the wind

Bermudashorts

Posted in: SCLP

Posts: 10,830

Price: 5.45

No Opinion

RE: Ruck13 Jul 2020 11:00
Chelsea,

I'm out and about at the moment, taking one of the kids to an appointment. Just wanted to quickly say that my post wasn't aimed at anyone in particular. We are where we are and I'm certain that we actually all want the same outcome. Will reply fully when I get back.

Missing ........... "the reply"

polite reminder

what has that got to do with mine or Konars post ........... both directed at the SP ... ?

infact if you are going to apply it that way .,.. Konar mentioned many numbers .. why have you not transferred those to Mcap ... rather than SP as Konar used

the Mcap will always have a Number .... relative to SP and share in issue ... or is this something you have discovered ...

Mind you 5 recs, suggest 5 did not know .............