Member Info for inanaco

Ruck also posted earlier ....

""" No negatives on the science from me """

so Game over then ...

not exactly risky if you cannot identify it ... like trying to jump a traffic light on Green ...

""""""""" The data on SCIB1 suggests a higher price than 5.5 may be achieved."""""""""

thank the lord for that .......... End

oh .. sorry it was posted on your account .. ATB

i did not know it had been hijacked ...

its not really an example is it .......... your forecast is £10 ...

the data on SCIB1 .. v Mcap .. also = no risk here ...

ATB

its not incorrect ...

No risk here ...IMHO >> as i am the writer

how YOU perceive that statement is up to you ... if that is your only compliant after 32K posts ... well ..

for me there is no risk .......

Risk is personal ..

only you make it universal ...

Fair enough ... perhaps Bermuda might better explain himself as he has suggested he would

Evade .......... what are you Ruck now working for HMRC ?

what sparked the debate was not me ... it was mHighbar, and I asked the same question ....................

inanaco

Posted in: SCLP

Posts: 31,838

Price: 5.35

No Opinion

RE: SCLP now has the valuation of a startup!07 Jul 2020 18:21
"""The aim of my post was to see to what extent other investors had similar thoughts about issues related to the overall management style in order to bring them up at the AGM in a concerted way. """

that will never work from just posters on here, for a start quite a few of the questions you would like answered are price sensitive or locked in via Non Disclosure ...........

you then posted

"""So you may also want to question the market why it values the company at this ludicrous level""

and how do we do that exactly ??

"HOW DO WE DO THAT EXACTLY"

call a friend ?
ask the audience ?

or just throw a hissy fit because he could not explain his own post .....

Hissy fit wins

Now if you feel you can present a NEGATIVE .......... better ....

That actually stands up to scrutiny ...........

Best of luck ....

if you understand the Balance principle of treating cancer ........... you can build the check list to see how scancell has overcome each of the hurdles ...

Moditope

Peptide vaccine because its so immunogenic

add 3 peptides that don't conflict to make sure you can clear all systemic cancer .. (mets)
test in all HLA types to increase patient diverse immune systems
Slew the CD4 to Pro Inflammatory and reduce the amount required by 100 fold .. use Amplivant
Switch to Hydrophobic peptides for better response .. but difficult to design a scale up process from lab to manufacture
Done
Find Homocitrulline to treat cold cancers that is even more potent than Modi1 .. and can work together
develop Mab 2811 to identify specific potent t cells for TCR transfected
Huge learning curve for both Scancell and BioNtech ... as they collaborate on what is a never generated before Cytotoxic CD4 from vaccination .........

mind blowing ...

"" Some of the things he comes out with are just plain wrong""

be interested to see that post Ruck ... "in context"

unfortunately Ruck ...

I can only ascribe real value to Scib1 alone because we have patient data ........ because Synergy has been proven in other trials like genexine and keytruda .. unless the market accepts "actual" data from keytruda and Immunobody generated from previous trials ... has to be synergistic ... out will pop MR "unproven"

but the moditope trial ... could be mind blowing on the SP ............. because of its potential efficacy across so many cancers

it has far wider applications than Keytruda has ..........

yet the market is oblivious to what Lindy has achieved ...

rather than asking why have you not done a deal yet ....

you should be looking at how they are doing deals .....

Proving up the pre-clinical first

ON

TCR and Avidmab , SCib2

products scancell can allow to be licensed even with SCIB2 the option to take back if the data is over whelming

but sell off the lead product before Data now we have Combi pre-clinical ........ Not on the cards ... why would you, if you trust your own ability ...

real Value = 100's of millions by the way

but you still keep bringing up 4 years ago C7 ... you should accept its in the past and get over it. I have not got involved with any dispute involved with you for years ... even your TF wars i stayed out of it ... and that was very recent ..

let he who is without sin cast the first stone

From memory

C7 attacks

knowlesi
Lemoore
Smiley
Tosh
Lozan
Yoda

the list goes on and on .............. read your own history C7 ....

Immunobody solves the problem of Low affinity exhausted T cells ......... by giving High Avidity as explained previous this T cells are not normally given hi Avidity as they are very reactive .... hence Scancell can claim Potent ...

Keytruda has shown and proven itself to lock onto T cells ...... ..... Proven you cannot argue it won't latch on

so that is two parts on the left scale sorted ...

Gravity hopefully takes over

Immunobody also generates CD4 helper Cells both Scib1 and 2 have CD4 support ........ both slewed to TH1 pro inflammatory because of the multiple signalling by immunobody these are effector cells and will suppress the CD4 suppression cells

third assistance to the left of scale ...

but some patients will have lost antigen ............... we cannot help them

But Moditope can ...................

because it "forces" presentation of MHC 11 epitope ... its one area that the cancer uses Autophagy to its benefit when it gets stressed to stay alive that actually assists the vaccine rather than diminishing it ... and for that you need to modify the epitope and citrullinate it ... Modification 1 .... Modi1 it then becomes extremely immunogenic ... so much so it activates the very rare CD4 CTL ....

once you have convinced yourself of that like i have done ...........

“ludicrously cheap price” takes over ...

ATB

In physics, gravitational acceleration ........................ is exactly the same with the adaptive immune system

Ruck ...... Every thing in this business revolves around Two key components as the start point ..... the antigen and the T cell

theory being the Antigen that is foreign to self that elicits an immune response will be killed by an activated T cell . the basic format of the adaptive immune system.

so if you want to make money ................ the only way is to find the antigen .......

but there is a catch ............... Cancer is clever it escapes the immune system and at that point your are doomed
because the cancer has hijacked the checkpoints that calm the immune system ..the major ones being
low affinity T cells that are exhausted
Pd-1
Ctl-4
Suppressor CD4
antigenic loss
so First problem is solve the T cell mystery ...... "affinity and avidity" and the Th1 issues ....

so if you break everything down into the Negatives effects of the immune system as a balance ....

left is what the immune system can do .................. and right is what the cancer can do ..

you will build a picture of how to tip that balance to the immune system ......

as you know if you tip the balance .....gravity takes over ..... that is our business
you do not need an all encompassing solution just enough to get it started ...

Bunsie
Bought another Bike yesterday to add to the collection .... Mint Triumph 955i Daytona ... a little pocket rocket ..

Ruck
Well the Good news you have not sold, so i presume you are happy to wait ... for the trial to progress .

meantime ..

Cricket and F1 ..