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Thanks WTB and Bunsie

Al Edwards, associate professor at Reading University’s School of Pharmacy, offers an analogy. “T-cells are tasting the virus whereas the antibodies are feeling the virus,” he said. “T-cells can promote antibody responses and antibody responses can promote a T-cell response. These two systems work together.”

which is what i have been saying about Oxfords Claims of Success with a T cell response ........... as an Addition ...

when in reality they work together

as i have explained the system needs more than one signal to activate against a new pathogen

why ...........

Imagine if a Rogue naive T cell escaped the thymus ..... but this time against "self" ... and it could "self activate " no checks and balance ........ you are about to be eaten by your own T cells .. that is why multiple signals are needed to "confirm" a pathogen , infected cell, or a self cancer cell ........ is Rogue ..

dont confuse that with memory cells .......... these cells have already been through the signalling process so do not need secondary signalling ... which is why the response is so rapid the second time .............

The immune system also goes through "natural selection" ... so the more exposure to the Pathogen results in stronger and stronger binding ... this is why a second injection of vaccines maybe a month apart ... improves the quality of the memory cells generated ...

Indeed the SCIB1 trial demonstrated that repeated vaccination up to 10 times improved the vaccines chances of all of the epitopes are picked up by the immune system that were included in the vaccine and the potency increased because of natural selection

https://www.ncbi.nlm.nih.gov/books/NBK27090/

"""Well I admit I have not got a clue what is going on in several of their heads but they need not worry about me wanting a lower SP as there seems a big inverse correlation between the glee club ramping of SCLP and the SP performance.""

Glee Club ???

lol

Ruck i will remind you of the post you replied to ...........

see ........ you have not quite got it right .......... the backfire is you LOL ....

inanaco

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RE: T Cells in antibody productionFri 10:37
you get ............ 200 institutions building a Covid vaccine

how many can build a cancer vaccine that actually works ...

the Gold standard is a Cancer vaccine platform

not a virus

you missed the point totally ........

how many cancer vaccines are successful !!

i expanded the link Ruck to 100 on the page

interesting all of them ""Active, not recruiting""

reminder

RuckRover

Posted in: SCLP

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RE: T Cells in antibody production17 Jul 2020 10:45
I would suggest there are far more cancer vaccines being developed than 200.
I would suggest there are more cancer vaccines in clinical trial than 200

as a foot note ...

Ruck suggests there are at least 200 ... in trial ...

maybe he should list them .. or better describe the post as " only Joking"

Max i appreciate its a long haul......... to get into the clinic and we still don't know the impact of the pandemic on our "Trial Investigator" and exactly how He will proceed.
As for any party "leap Frogging" .. a clear front runner would have appeared by now . and indeed in every sector of Vaccine platforms ... few stand out ...

and with Moditope they do NOT have access to the fundamental technology because of the patents

same again with Immunobody ... I hope you appreciate that is Direct To Dendritic cell vaccine ..

but even Genexine who i am impressed with ... don't get it right

http://www.koreabiomed.com/news/articleView.html?idxno=5119

The company's anticancer drug is a dendritic cell-based personalized cancer vaccine. Argos conducted a phase 3 clinical trial on 460 kidney cancer patients at 120 institutions in the U.S., EU and Israel.

However, the company failed to prove statistically valid data when comparing it with the control group and decided to terminate the study on April 19, 2018. NASDAQ decided to delist the company stocks in April 2018.

The point in question these "personal" vaccines should be "WOW" ... enormous cost and they are Tailored ...

exactly the same as Roche and BioNtech ............

https://www.fiercebiotech.com/biotech/roche-biontech-post-low-response-rate-cancer-vaccine-trial

Now if Scancell achieve's objective rates ... who exactly is the competition ?

Every one raves about Big Pharma ....... but most of what they have backed so far ... has Flopped ...

the reason why we have not flopped .. is because its taken 20 years of research to get ............ Potent T cells immunobody

and the reverse of that is "Potent epitopes" ......... Moditope

katerina will love this ..........

what i would say as we are getting on a bit while watching scancell develop ......... we are approaching winter again .. maybe worth stocking up on natural remedies, it just might give you an edge ... Chewing Raw garlic ? who is brave

https://oand.org/uncategory/top-ten-natural-anti-viral-agents/

https://www.nature.com/articles/s41467-020-16256-y

Possible Bermuda ... a Lot of work is being done in this area, if something potentially enters trials as a late stage treatment ie as an infusion product .. like you would use Keytruda ... then a Mab could be enhanced with High avidity ..but you don't need the killing ability of Avidmab as the virus is dead until it enters a cell, so you only need to neutralise but of course that is a consequence of vaccination anyway .. and a T cell can still target that protein even thou its covered in these sugars

Glycoproteins are proteins that have sugars attached to them. They do many important jobs for the body, such as helping the immune, digestive, and reproductive systems.

Glycans are essential to virtually every biological process in the body. These complex structures -- composed of interlocking sugar molecules -- adorn the surfaces of cells in fuzzy profusion. Glycans are a crucial part of a cell's identity, helping it communicate with other cells and with the external environment.

so the S spike is a glycoprotein

we are walking chemistry sets ....... amazing how its all developed ..

Viruses did not evolve first, they found. Instead, viruses and bacteria both descended from an ancient cellular life form. But while – like humans – bacteria evolved to become more complex, viruses became simpler.19 Oct 2015

some advice Ruck

Get yourself a "tens" machine .. for your back ... keep turning up the current until you are fully able to stand it ... keep it on for 10 mins .. 3 or 4 times a day ...

ATB ... (Transcutaneous electrical nerve stimulation)

lets hope the covers don't come on because of Drivel .....

can't argue with suggesting ...

ATB ...

cricket ..

suggest we may see 2 x 100

you get ............ 200 institutions building a Covid vaccine

how many can build a cancer vaccine that actually works ...

the Gold standard is a Cancer vaccine platform

not a virus

this one paragraph highlights the step up ....

step 1

The advances and challenges described above encompass the four main types of vaccine in preclinical and clinical development (see Table 1). Prophylactic vaccines are designed to trigger immunological memory in healthy populations to prevent disease on future exposure, and are often based on the induction of long-lived neutralizing antibody responses.

more difficult
step 2

Therapeutic vaccines seek to raise an immune response in the face of ongoing disease (for example chronic infections such as HIV or human cytomegalovirus, or cancer). These vaccines must overcome pathogen-mediated evasion of the immune response and are likely to require induction of strong cytotoxic T-lymphocyte (CTL; activated CD8+ T cell) responses to deal with pathogens that have already established intracellular infections. But the mechanisms for inducing potent effector and memory T cells while avoiding T-cell depletion, desensitization or excessive inflammation remain poorly understood1.

even More difficult add

step 3

In the case of cancer, therapeutic vaccines may also need to overcome a variety of suppressive mechanisms used by tumours, such as immunological ignorance, exhaustion or tolerance to tumour antigens.

https://www.nature.com/articles/nmat3775?proof=trueMay

this one paragraph highlights the step up ....

step 1

The advances and challenges described above encompass the four main types of vaccine in preclinical and clinical development (see Table 1). Prophylactic vaccines are designed to trigger immunological memory in healthy populations to prevent disease on future exposure, and are often based on the induction of long-lived neutralizing antibody responses.
more difficult step 2

Therapeutic vaccines seek to raise an immune response in the face of ongoing disease (for example chronic infections such as HIV or human cytomegalovirus, or cancer). These vaccines must overcome pathogen-mediated evasion of the immune response and are likely to require induction of strong cytotoxic T-lymphocyte (CTL; activated CD8+ T cell) responses to deal with pathogens that have already established intracellular infections. But the mechanisms for inducing potent effector and memory T cells while avoiding T-cell depletion, desensitization or excessive inflammation remain poorly understood1.
even More difficult add step 3

In the case of cancer, therapeutic vaccines may also need to overcome a variety of suppressive mechanisms used by tumours, such as immunological ignorance, exhaustion or tolerance to tumour antigens.

https://www.nature.com/articles/nmat3775?proof=trueMay

this is the problem ............ Most fully understand the posts and how they are applied in context

You Don't Ruck

what can i do ? ......... what can anybody do ... ?

the topic was my post

only you are trying to change it ..

to something other than my post

Ruck

I gave a version of my take on the gold standard ... of a vaccine

still waiting to see yours as it got diverted to
Trials
then Bermuda kicked in with inappropriate use
not seen his explanations either of why a cancer vaccine is so easy every one can do it ...........

after all it seems 200 different research centers can build a covid vaccine .. inside 3 months !!