RE: How many Bio shares8 Jan 2019 13:23
Lets look at what CRUK are looking for .............. 8 grand challenges
The first we meet
Identify and target tumour cells that remain dormant for many years after seemingly effective treatment
Dormancy Grand Challenge?
Sometimes, patients who seem to have been successfully treated for cancer can have the disease come back years or even decades later, often without any warning.
It’s believed that cancer cells that weren’t killed by initial treatment can go to sleep, lying dormant before a new chance to grow kicks in. But what causes some cancer cells to go sleep, or where they hide when they’re asleep, is unknown. Scientists also don’t know for sure what wakes these cells up years later.
This Grand Challenge aims to shed light these unknowns. This could lead to new ways to find these cells and eliminate them. Or, if we could predict when they’re about to rise from their slumber, keep them sleeping permanently.
In a sentence: Understand how some cancers come back many years after treatment
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the second one we meet is
Create novel tumour vaccinology approaches that establish or enhance successful immune responses beyond what is revealed by current checkpoint therapy
Tumour Vaccinology
The body’s immune system is a powerful force that is constantly fighting disease to keep us healthy. But cancers often work out a way to get around it.
Treatments that reveal cancer to the immune system so that it can recognise, target and kill cancer cells have been showing promise. But they don’t work in all patients, or against all cancers.
That’s because right now we don’t completely understand how the many different parts of the immune system work together, or how they interact with a tumour.
This Grand Challenge aims to improve our understanding of the immune system and its role in cancer so that new immunotherapies can be developed, and those already available can be used more effectively.
In a sentence: Understand how immunotherapies work so doctors can identify who will benefit from them
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The third we Meet
Define mechanistic rules for combinatorial treatments to overcome resistance and avoid toxicity
Treatment Regimens Grand Challenge
While some cancer cells are killed by treatment, others can survive. This is why some cancers can come back. The cancer cells that aren’t destroyed can continue to grow, forming a tumour again.
To get around this, doctors often give different treatments in combination. But it’s not always clear which combination is best, or how much of each treatment to give, or when the different treatments should be given.
This Grand Challenge aims to find clear answers to those questions by improving our understanding of combination treatments. If we better understa
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