RE: Vaccine orders15 Sep 2020 19:43
Nucleic Acid Vaccines
Nucleic acid based technologies employ either antigen encoding plasmid DNA or RNA, as messenger RNA or viral replicons. Upon their cellular uptake and expression, nucleic acid encoded antigens can elicit humoral as well as cell-mediated immune responses. Both technologies are extremely versatile due to the ease of antigen manipulation they allow. The production of antigens in the target cells offers the advantage of mimicking protein synthesis during an infection, i.e., protein localizations such as presence in the plasma membrane and modifications such as glycosylation patterns can be formed with a high degree of faithfulness. Importantly, they support the delivery of any antigen of choice, regardless of whether it was derived from a virus, bacterium or parasite, supporting vaccine development against a wide array of pathogens. Since vaccine characteristics are independent of the encoded proteins, development of different vaccines can take place without the need to establish new production, purification and validation methods as well as manufacturing facilities. Hence, nucleic acid based technologies support fast and flexible vaccine development and production. Since all vaccines can be produced using the same basic components, manufacturing of several vaccines can take place in one established facility cutting both costs and time of vaccine production dramatically. Lastly, their synthesis mostly relies on chemically synthesized material, supporting large-scale production with relative ease.
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