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incredible i read your post rats replied to it .. now my reply is ahead of yours ....... proving that Glitch on posts disappearing is real

opps Rats ............

I know Ruck and some fall for it, Hook line an sinker

memory ....

which post is correct Crackin ........... you have all bases covered ..

Crackin

Posted in: SCLP

Posts: 185

Price: 8.65

No Opinion

RE: MCap of £53m Cash of £20m27 Aug 2020 10:45
Rats - That is rich coming from you.

The Astute have called it right for years. Now is the time to buy IMHO but talk of 19p by November is ridiculous when this Company has failed time and time again to deliver shareholder value.

You can see there are a lot of PIs desperate to reduce their holdings by the trading today. They have suffered years of misery and now as the green shoots appear, they bail out.

you need to blame "Crackin" the "Astute" ......... he promised us the stars are aligned ...

all the way through the rise ... people sold into it ... some thinking 10p was a limit .. with hindsight we would all sell at 18p to One poor chap ... then the same chap would get panicky and sell back to us at 14p ....... but in the real world ...

I cant buy back in at a suitable price if the news breaks Max ...... everyone assumes you can ... until the day you Can't ...
that has been the entire reason for holding Scancell for the period .. that is why we had to endure years of Rucks heart ache because of that potential "one RNS" ... hindsight is wonderful ... but its not real

wow ! i would not sell any at this level ....... why would i ... I know whats coming ..

I blame Scancell for all the Good stuff they are coming out with and the High Level investors that have joined the Ride, this has destabilised the Share price causing a lot of interest in the share and sending it Up ... how i wish for the days when we fluctuated around 6p ...

Oh No ... A small Pull Back and the inquest starts ..... lets Blame Scancell ..

I am with Sweden ......... part of the Flat earth Society ...

I don't normally post the Guardian ... however .. take a look

https://www.theguardian.com/world/2020/sep/15/sweden-records-its-fewest-daily-covid-19-cases-since-march

i do not know why but instinct goes to deceased ... to much cancer posting maybe

However ... seems Sweden did get it right ... the graphs look impressive compared to the rest of Europe

disease

the trend of decease spread is up ............ ATB

Moditope

shown ........ these Guys are the star performers when it comes to "clonal Expansion"

Scancell science is Brilliant . its all there you just have to Highlight the Good stuff

To further confirm that GPR56+ TEMRA cells were major components of IFN-?-producing cells in response to DENV, we sorted GPR56+ and GRP56- TEMRA cells from secondary DENV-infected donors (Supplementary Fig. 1c) and measured their production of IFN-? after stimulation with DENV CD4 T-cell megapool. We observed that a higher proportion of GRP56+ TERMA cells produced IFN-? compared with their GRP56- counterparts (Fig. 7d), further supporting the notion that DENV-specific TEMRA cells predominantly adopted a GPR56+ phenotype. Taken together, these data suggest that DENV-specific TEMRA cells are associated with a cytotoxic phenotype characterized by the expression of markers such as CD244, perforin, and especially GPR56. This is consistent with the observation that these cells were clonally expanded, which could result from multiple rounds of DENV infections.

Moditope ... From the Scancell archives

CD4 responses are highly clonal and showed TEMRA (highly cytotoxic
effector memory cells) or effector memory phenotype.
? Some donors showed a pre-existing (memory) responses to
citrullinated peptides.

? Repertoire to citrullinated peptides exists in cancer patients that
could potentially be boosted by immunization to assist in tumor
eradication.

Abstract
The expression of CD45RA is generally associated with naive T cells. However, a subset of effector memory T cells re-expresses CD45RA (termed TEMRA) after antigenic stimulation with unknown molecular characteristics and functions. CD4 TEMRA cells have been implicated in protective immunity against pathogens such as dengue virus (DENV). Here we show that not only the frequency but also the phenotype of CD4 TEMRA cells are heterogeneous between individuals. These cells can be subdivided into two major subsets based on the expression of the adhesion G protein-coupled receptor GPR56, and GPR56+ TEMRA cells display a transcriptional and proteomic program with cytotoxic features that is distinct from effector memory T cells. Moreover, GPR56+ TEMRA cells have higher levels of clonal expansion and contain the majority of virus-specific TEMRA cells. Overall, this study reveals the heterogeneity of CD4 TEMRA cells and provides insights into T-cell responses against DENV and other viral pathogens.

https://www.nature.com/articles/s41467-017-01728-5

so as i have explained before .... Immunobody generates T cells that are Potent, indeed hIgh avidity T cells are deleted before they are released by the thymus

""""To gain immune recognition, the tumour must present an epitope that has avoided thymic regulation and binds with higher affinity than the self epitopes. This could be a neo-epitope which is
formed by a mutation that occurs during oncogenesis, cancer-associated viral epitopes or post translationally modified epitopes. Moreoccasionally, there are epitopes from self antigens that have avoided thymic deletion."""""""""""

I suspect the reason why they don't use Immunobody ........... the immunogenicity of the citrullianted peptide is to high

Your thoughts burble