Member Info for inanaco

Inanco, you're losing me now - what is license, profit share?

a missing coma

time to close ... have a good weekend ...

look how many deals are done on license profit share and joint ventures etc ... then the Big player takes them over

how many pharma Bio has the potential to offer so many agreements ? Scancell is a bit special in that respect

yes avidmab has that potential as well ...

disagree most get taken over ... or go on to manufacture and develop there own sales once they have core income
i just think the scancell team thrive on invention ...

yes ... but its the license of the chips the target is the software written by the user so its infinite

Scancell develop the platform and license the targets same principle it does not sell or manufacture

both would have royalty streams

but always retain the core .. the platforms or the chip design

if you look at FAB ..... for a SP move on covid ..

why non exclusive ?

exclusive is the target not the platform

well we can rule out dilution as a discussion !!!

more time spent on orange juice than Spain took to grow them ...

can rule out "Risky" .... what does that mean ... keep an eye on Risky ... ? you buy or you don't there is No Risky half in half out share ...

Arm Holdings ... mine

.... Kate Cornish Bowden ... wonder what she is up to ... legs discussion ?

lol

by the way the Thai online shop ... impressive delivery well packed and on schedule ... worth an order

another rec from Nana's Kitchen

https://www.pataks.co.uk/products/oven-bakes/tikka

authentic ... !! cook up some onions with Garlic first then Bake diced chicken after marinade

talking of Curries ... i tried this place https://www.thai-food-online.co.uk/collections/thai-green-curry-pastes

I tub made 4 frozen meals ......... so spicey i had to dilute each meal by two with a tin of tomatoes and it still makes me sweat and it gets stronger after defrost ........ wow ! what a Taste

I read the Beano as a Child ...

Its really important that investors when looking at Scancell consider secondary effect .. by flipping the environment of cancer to pro inflammatory you are also bringing into play other active members of the immune system

so Avidmab could trigger an adaptive immune response ............... ie The MAB never meets the t cell but activates it via the Molecular damage it causes ...

Avidmab also can utilise "DAMPS" ... to spark an immune response by releasing DAMPS into the environment

PAMPS and DAMPs both activate similar Pathways of the Innate Immune system

""""Once these PAMPs bind to their receptors, a signaling cascade is triggered that, among others, leads to the activation of cells that initiate a potent acquired immune response."""

Burble post assists in the peptide migration so it something to do with the way the innate system picks up the peptide and presents to the Dendritic cell ... no antibody involvement ..

no no amplivant is vital in how the DC encodes the T cells .. however the migration of the peptide i assume via the innate system maybe be also influenced by the adjuvant .. TRL2 conjugated to the peptide

TLRs expressed by immune cells such as dendritic cells (DCs) or macrophages play a key role in innate immunity. They recognize characteristic molecular structures present on the surface of bacteria, called pathogen associated molecular
patterns (PAMPs). Once these PAMPs bind to their receptors, a signaling cascade is triggered that, among others, leads to the activation of cells that initiate a potent acquired immune response.

https://www.isa-pharma.com/technology/amplivant-technology/

https://jitc.biomedcentral.com/articles/10.1186/s40425-018-0455-2

Not seen that Ray be interested to find out how that works .. amplivant conjugated peptide being picked up by the DC ... Burble have you a link to that ? ATB

Co-stimulation is a secondary signal which immune cells rely on to activate an immune response in the presence of an antigen-presenting cell.[1] In the case of T cells, two stimuli are required to fully activate their immune response. During the activation of lymphocytes, co-stimulation is often crucial to the development of an effective immune response. Co-stimulation is required in addition to the antigen-specific signal from their antigen receptors.

https://en.wikipedia.org/wiki/Co-stimulation#:~:text=3%20Applications-,T%20Cell%20Co%2Dstimulation,antigen%20presenting%20cells%20(APC).