Scientific Paper26 Feb 2024 16:53
We are delighted to share the release of our latest scientific paper outlining a drug delivery strategy poised to redefine cancer therapy.
Here's an overview of what we've uncovered:
Addressing treatment challenges: Current approaches to cancer treatment are limited by high general toxicity and low efficacy, driving a pressing need for novel, innovative treatment strategies.
Unlocking potential with combination therapy: Drawing inspiration from successful combination treatments in other medical fields, combination approaches could hold tremendous promise in enhancing treatment efficacy and overcoming resistance mechanisms.
Focusing on siRNA delivery: With small interfering RNA (siRNA) becoming increasingly used in the development of therapeutics, it is critical that these nucleic acids are delivered to tumours safely and efficiently. Dual delivery of siRNA, with or without a relevant, additional, small-molecule therapeutic agent, may be the key to unlocking a new era of treatment efficiency in cancer.
Innovative delivery platform: Departing from conventional delivery methods, mesoporous silica nanoparticles (MSNs) offer a potential solution for precise drug delivery. A novel silica nanoparticle delivery system has been developed (Nuvec®, N4 Pharma) specifically to safely and efficiently deliver siRNAs to tumours to inhibit multiple tumour growth factor pathway. Novel delivery systems that allow for double or even multiple siRNA loading will be critical to the success of future siRNA-based cancer therapeutics.
We believe this drug delivery approach provides a clear strategy to pave the way for more targeted and efficient first-line cancer therapy. A solid delivery platform will be pivotal in allowing developers to realise their goals.