Member Info for HelloSanDiego

TLR - Top line results, presumably.

They're obviously not as knowledgeable about these things as you are Tattyhead.

Andy's confused "STRucture-guided Influenza Vaccine initiativE (STRIVE)" project with the "Strategies and Treatments for Respiratory & Viral Emergencies" project.

This is the easiest one of his angry rants to deal with because it only takes a few seconds to understand how he got confused.

Andy, that's a different STRIVE trial.

Here's the new one: https://dcricollab.dcri.duke.edu/sites/NIHKR/KR/GR-Slides-07-15-22.pdf

I'll be surprised if Polygon hasn't started buying again.

A month ago they were paying close to 30p a share. With an upcoming trial announcement expected, it appears they weren't confident of seeing the low 20's again. If it turns out we're on the Strive trial I think this will hit 50p instantly.

Thanks for the help everyone. I'd googled "Strive" with NIH, FDA etc a few times in the past month or two but it's a generic term and turned up nothing helpful. There have even been other clinical trials with that name that were entirely unrelated to Covid.

But this slide from a month ago about the Strive trial which follows on from Activ estimates that the first patient will be enrolled in August. I'm inclined to agree that the optimism Synairgen's drug will be included is well-placed considering it's one of the few drugs seen as likely to be as effective in treating other emerging respiratory infections.

https://dcricollab.dcri.duke.edu/sites/NIHKR/KR/GR-Slides-07-15-22.pdf

What is Strive?

I can't find any mention of it outside of here and ADVFN.

It looks like there are some valid reasons to doubt whether Evusheld would actually offer any benefit. The Daily Mail is a terrible source of information. Here are two much more sensible ones:

"EVUSHELD is not an FDA-approved medicine in the United States"
https://www.evusheld.com/en/patient

"Not a lot of people have been given Evusheld... Evusheld is not FDA-approved to prevent or treat any diseases or conditions, including COVID-19. Evusheld is an investigational drug."
https://www.fda.gov/media/154703/download

I get the impression from the comments on here that most of you had never invested in drug development firms prior to covid.

Has anyone asked the company for any possible reasons why the Activ-2 results are taking so long?

Have any other Activ-2 drugs had their results released by the NIH or NIAID yet?

The_Palladin - "No communication is useless. "

You must be new here. Pick any ten comments on this forum and at least eight will prove that statement wrong.

...that's assuming the Activ-2 data is on par with what we've already seen, and not surprisingly good or bad.

I don't expect the Activ-2 data to make much difference to the price, especially if another platform trial has already been announced by then. But I think we'll hit high 60s if a new trial is announced, and will probably stay above 50p.

Dumbpunter - "This is a share for day traders, nobody else."

If you're looking for people to take your opinions seriously, you might be better off posting on Twitter.

Nearly midday and only 29k shares traded today, with a 7% spread right now?

I expect we'll see the other million suddenly appear late Friday/early Monday and we'll get another TR1 early next week.

Wigster77's comment from 21:30 last Thursday is where the "tens of thousands of doses of active treatment and placebo" came from. I believe he was one of the posters here who attended last week's AGM.

wetdream - "when I see no mention of SOC I take it we’re up against placebo - which is what’s stated in this version of SNG018"

So you thought some of these hospitalized patients would be given nothing but a placebo and told to keep their fingers crossed?

wetdream - "What puzzles me is why there’s no mention of SOC in the US trial protocol."

Probably for the same reason they didn't explain that the weird symbol at the end of 50% is a percent sign, and it means 'out of every hundred'.

It's up to us to understand at least the basics of clinical trials, and realizing that they're not going to deny patients the best proven care just to trial an unproven drug is part of that. It would clearly be unethical.

Most of you guys are bright enough to pick up on obvious sarcasm, presumably.

Docdaneeka - "They are holding it until a decision on the trial is made."

Yeah they're working overtime to get Covid therapeutics into hospital but they want to delay this particular one for some stupid, illogical reason that seems implausible to anybody who knows what they're actually talking about.