Member Info for Grace83

I’m desperate to see them! Do you have any idea of when they are most likely to land?

Hi Jenny
Pretty sure I can answer this without having to ask Suzy, but you’re obviously welcome to do so. This is pretty standard for a phase 1 trial, where the main aim is to assess safety, tolerability and optimum dosing. Phase 1 is rarely carried out on more than 20 people ( the most I have Personally encountered is 25, as they were incorporating phase 2 too and were very confident of the drug) due to the high levels of cost of clinical trials, as they basically want to see if it works in humans at this stage. We have taken this further by making it a phase 1/2, just like DDDD, whereby we also begin to assess how well the treatment works on cancer cells. This can then be expanded to more people afterwards, at the optimum dose, which has now been established by the end of this trial. You are correct, in that it did wonders for DDDD at just a 42% success rate :)

That’s an interesting point actually...I wonder how many shares she still has?!

Ha...I’m afraid I wouldn’t have the faintest idea of how to interpret what’s going on, sorry! Out of interest, I will start asking around, to see if I can find anything out. This isn’t a big place here, so I’ll let you know if i get wind of anything at all. Valuefinder is our resident mining expert!

I’m very skeptical about this being Satu. Saying that, there are a few things about it that ring true and fit with her behaviour when she was CEO. I’d say I’m 50/50.

For whatever the reason,( I agree with Valuefinder in this).crazies seem to have an agenda and come out when something big is about to happen. Personally, I’m desperate for this to actually be Satu, as when is the time she would be most aggrieved about being booted out of the company? Before it does really well and she knows she won’t be rewarded at all for her earlier ‘efforts’, I’d say.

It is my understanding that they wouldn’t be allowed to use this particular treatment, unless they are working for, with, or have the permission of ValiRx.

More tonic...? Now you’ve really lost me ;)

Apologies, I’m a bit slow this morning...I blame the gin..

Are you referring to George or part of the old team being able to use this medication outside of these settings?

Was meant to be a smiley face, they clearly don’t work on here!

Well said that man ??

I’ve been pondering the same thing. Think I’ll top up next week. This could go down much further when other news outlets get hold of it. Just going to keep topping up on these dips...

I really enjoy your L2 updates, thanks

Quiet day, sharegnomie. I don’t believe the pattern of buys and sells being reported either. If they were true, then we would be back in the 13’s by now. Look at all the apparent big sells with no real buys for the past few hours

Great post Teamhanz.
201 could potentially keep on giving...:)
Waiting for news on SNG now, to then top up here before results.

So the way I read it is we have a response to 201. So even in the worse case scenario so far, in that we have Already measured the size of the tumours, our participants are responding to it and the tumours aren’t getting any bigger at the low doses. That’s a high patient response rate, at least.
Excited to see the higher doses now, to see if those caused more of a response and started to shrink them.
Wish I knew how far we analysed the data from the first trial, to see if they actually measured the tumours yet before publishing the first set of results I’ve seen. It does say the data analysis was ongoing, but that’s too vague to satisfy my curiosity! Hurry up 201 results!

Yes, very encouraging. There are some different aspects to their trial than ours. I’ve only seen data for eight people, the other four must have been added in the extended trial. I initially thought it would have ended up being more than 12, but that’s what we have. So that’s the same as them. Not everyone completed our trial and we ran the initial one for six months, so some of our data will be for a shorter period. Also I don’t know if we carried on Collecting data from people after officially our trial ended at six months, as they did. We should have, as it’s meant to be ongoing for the people that produced a positive response, to keep monitoring them. I also don’t know the timeframe for the extended trial. The major advantage that we have is that imaging showed stable disease in seven of our eight (at lower doses as it’s only from the initial trial...woohooooo!) although As I mentioned earlier, at least some were for a shorter timeframe than their trial. So for a patient response to the drug, they are at 42% and we are already at 88%. Three of their patients from the Five that make up their 42% had partial tumour shrinkage and that is an unknown to us at present, as the results that I saw weren’t complete, so not sure if we were actually measuring tumours to see if there was a reduction at that point, or if that would have been done later. Our scans showed that they certainly weren’t getting any bigger and just showed a summary table stating stable disease, with no further Information. I can post the summary page of the results, if anyone is interested to compare with DDDD? To spare you all from me waffling on. Not sure if they’re in the public domain or not, as cant remember where I found them. I know it took a fair bit of searching. That’s pretty must the gist of it though.

I’ve been keeping an eye on them, but not invested.
Yes, very similar trial to us, as doing a phase 1/2 of similar size. It appears they have had decent results, so can now test on more people before the next phase...same as we would need to do really. Well done and good luck to you all over there. Interesting to see this in comparison, as they have such a bigger mcap already.

Valuefinder
I’d already decided against Alba for now before I saw your message. Time will tell if that’s the correct decision or not and I’ll certainly be keeping an eye as it’s progressing. I’ve noticed you are also in GGP...something is brewing there these past couple of days I think. Apart from this, it’s currently my other favourite AIM share.
No I’m not in HEMO...how is it treating you? Pharma is such a minefield as the science can throw anything up at you. I did well from SNG, but I always feel like pharmas are a gamble. I’m fairly keen on diurnal, it’s done well for me so far, but again, would be very reluctant to advise anyone and does depend on FDA approval of one of their drugs in the next month...have you already looked at it?
I’d be interested to hear if you have any tips, as you really seem to know your stuff. I’m impressed you post on the ggp board, some scarily knowledgeable people there and it’s certainly a big learning curve for me regarding all aspects of mining and geology.

I’m enjoying this eat out to help out too...great isn’t it. That’s hilarious about the hand sanitiser!

I’m not sure how others feel, but I also think that with Time, patience, a bit of luck and much better management the sp would hopefully get a lot Further towards there for the lth. We have a few potentially good drugs in the pipeline and hopefully Valju is right about Suzy now taking this in the right direction. Also, Val 401 is her baby, so she will have more of an idea of how that works and it’s potential than anyone.
I’m skeptical of getting carried away and going as far as the many many multiples that some may think the sp will increase by on the 201 results alone, as it’s not a far enough advanced trial, from what I have seen so far. Hopefully the extended version will have been conducted in more detail , as the potential from the data so far is clearly excellent. This is a great start and while the final data should be good, we are all waiting to see exactly how much this drug has been allowed to shine in the extended trial. The 201 results are my focus at the moment, as they’re imminent and they should give us a good boost and a platform to carry on moving upwards from as I’m expecting positive results from them.
Thanks for the kind words Jenny, but I will try to keep it shorter from now on in my musings!

Sorry, I meant to say phase 2/3 earlier. As this is a phase 1/2 currently. I just don’t understand how they didn’t recruit more people, considering they had so long to conduct the trial. You must’ve been very frustrated at the time Valju. Let’s hope that things are carried out in a more appropriate fashion from now on with the new board!

That’s true Valuefinder. I’ve had a little look and won’t be investing at the moment. Although I wish everybody over there well. I can see there’s a few from here over there :)

Might have a little punt tomorrow morning...