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Telegram group is an echo chamber

I got removed from there also. RAH and his buds have taken over the narrative. If you don’t join the happy clapping club your out.

Any reason?

Energy Shares

That is a very optimistic take on the situation however it is still in the realm of possible.

Keytruda was approved for treatment of Melanoma after phase one study. Phase one study was large.

Jive Turkey

Has there been any information or anything that might indicate approval could occur after 2 weekly study?

Bellamy

What makes you think Avct will have a disasterous outcome?

Myles analysis on AVCT is outdated and has been superseded by time. Scientific results so far for Avacta are good and AS has given valuations comparing to other companies that seem to give current valuation of about $2Bn. The valuation by Access is back to over £2.00 as we approach phase 2. Myles track record with SAE, TGR and the like demonstrate to me that I should look for information elsewhere and not to follow a recommendation by Myles when deciding whether to invest or not. my own research leads me consider that the likelihood of a positive outcome is high

Hi Touk

Regarding the results

I think CC explains some of this in that is also confirms that

High FAP tumours cleave and release dox. Some of the tumours would not have been high in FAP. So this information would have been used to help them confirm their findings. Also explained in previous presentation is that some of the tumors are treatment resistant.

Without further information it is difficult to draw conclusions about the tumours that did no have shrinkage.

Think you misunderstood the double negative

It is unlikely we don’t get better results

Means

Likely to see better results

Meant to say 2 weekly intervals

Buena Vista posted ‘ route is pivotal Phase 2, provisonal regulatory approval and marketting, Phase 3 to check(finally prove) that it works. If Phase 3 were to fail, marketting approval would be revoked.’

Given the exceptionally good efficacy at this stage. I personally see it unlikely that we don’t get better results in pase 2 and phase 3. Given that we will be more selective and most likely dosing at weekly intervals.

Sorry that was supposed to be a question. Are Avacta seeking accelerated approval for AVA6000

So we know if Avacta are seeking accelerated approval?

Sorry it’s a negative comment, not trying to be a FUDster but that one caught my eye. Can’t really comment on the other stuff,

I was surprised to read about the dose limiting toxicities

Cause I am sure there were non reported in the December presentation.

My understanding of the term ‘pivotal’ is that data from that study is used to determine whether treatment can be brought to market.

Therefore most phase3 studies are referred to as pivotal and in some cases but not very often phase2 studies can be.

In these rare cases FDA or other relevant bodies can use data in order to determine if they wish to approve treatment for the market. Phase 2 pivotal trials are not common.

Are all phase2 trials for cancer treatments called pivotal trials then?

Who are you LOL at Kingsley?

Kingsley

Why does Wikipedia say , what I have pasted below about pivotal trials? Are all phase2 chemo trials are pivotal then?

Also if dox has been in use for over 50 years and there are already some indication of efficacy in phase1 and delivery system of delivering dox to the tumour via cleaving of FAP is working as it has been designed then chance of success surely is higher that a regular trial for a regular chemotherapy?

A pivotal trial is typically a Phase III clinical trial in the multi-year process of clinical research intended to demonstrate and confirm the safety and efficacy of a treatment – such as a drug candidate, medical device or clinical diagnostic procedure – and to estimate the incidence of common adverse effects.[1] A successful pivotal trial is required as evidence for drug marketing approval by the relevant approval authorities, such as the European Medicines Agency, Health Canada or United States Food and Drug Administration (FDA).[1]

I think t1/2 stands for terminal half life

Which is different from standard half life