Member Info for gixer

At the very least, DSM will be able to supply there existing customers. What else comes out of the DSM negotiations we will just have to wait and see.

Also good to be mentioned in Pharma related journals.
May even help towards the long term plans????

"(2) During the period of the drug research and development agreement, Provexis and the company will cooperate in drug research and development projects in accordance with the terms of this agreement, and the company has the exclusive right to develop drugs in the area under the agreement."
http://data.eastmoney.com/notices/detail/300146/AN202111051527225504.html

Provexis and By-Health will seek to collaborate on research and development projects which may result in the development and approval of Fruitflow as a drug, for potential sale and distribution in the Territories.
https://otp.investis.com/clients/uk/provexis_plc/rns/regulatory-story.aspx?cid=1569&newsid=1523432

P.S. Nice rise in B-H share price today. Showing 9.34%

Barbershop,
RE: but it wouldn't rule out us buying from DSM and them handling logistics to ship to China

Although a possibility I don't think that is the plan.

"The Agreement for Fruitflow announced today between the Company and By-Health falls under (ii) above, with the Company set to sell Fruitflow as an ingredient directly to By-Health from 1 January 2023; 100% of the Company's sales of Fruitflow to By-Health will accrue directly to the Company, and the Company will retain all of the resulting profits."

The company (PXS) is already in negotiations with the third party manufacturers.
"The Company and the third party manufacturers are actively engaged in some ongoing production capacity planning, looking at the steps required to scale-up the production of Fruitflow to meet the anticipated increase in demand."

Its a win win situation for Provexis and probably for By-Health as well as we could supply them with a cheaper product price and still come out with a higher profit.

Just in my opinion though.

Its a good guess and we can only assume that it was for Team DSM and we received £9.2k for the Fruitflow+ nitrates development products in the year so it must have been a few packs :)
Again, only assuming but Fruitflow + Nitrates would be outside the Alliance Agreement.

Strange the links didn't work so try this.

https://bit.ly/3EsCCmZ

https://bit.ly/3xZPYV3

Evaluation of the equivalence of different intakes of Fruitflow in affecting platelet aggregation and thrombin generation capacity in a randomized, double-blinded pilot study in male subjects.

https://bm****r.biomedcentral.com/articles/10.1186/s40795-021-00485-5

Peer Review reports
https://bm****r.biomedcentral.com/articles/10.1186/s40795-021-00485-5/peer-review

BB,
"negative" no
"paranoid" no
But if Barbershop, or anyone else, feels like I have jumped down his/her throat because I simply disagreed with there statement then I apologise. It was not my intention to come across that way.
As we have already agreed to disagree I am unsure why you feel the need to bring it up again but my opinion, rightly or wrongly remains the same.
As Provexis is responsible for the manufacture, supply and sale of Fruitflow to By-Health I don't see how they can be classed as the middleman.
Does it matter either way? No.

Well we will have to agree to disagree on this one.
As for "salting it", I am only stating how I see it.
One thing that is for sure is all the profit will go directly to Provexis from By-Health sales, not split with DSM and there share would have been more than 10%

You make it sound like Provexis is buying and selling some generic product like vitamin c. It's not.
Indena is a contract manufacturer and would be manufacturing Fruitflow under contract for Provexis. As though pxs was manufacturing it themselves.
So, to change my first thought. If there is a middleman then that would be By-health as they are buying from the owner and selling on.

Just my opinion but if there is a middle man then surely that would be the manufacturer. Its certainly not provexis.

Just for info in case anyone is not aware.

DSM does not manufacture Fruitflow but instead has a company in Italy/France to do this work and they are called Indena SAS.
Not saying this is were Provexis will have it manufactured but they are already set up and we will not have to go through DSM to buy it.

Barbershop,
Without wanting to sound cheeky. Can I suggest you read the RNS again?
"Provexis will be responsible for the manufacture, supply and sale of its Fruitflow heart-health functional food ingredient to By-Health, and it will contribute scientific expertise necessary for successful commercialisation."

The Agreement between Provexis and By-Health is totally independent to the DSM alliance agreement and 100% of the profit on Fruitflow sold to By-Health will go directly to Provexis and nil to DSM.

https://otp.investis.com/clients/uk/provexis_plc/rns/regulatory-story.aspx?cid=1569&newsid=1523432

everhopeful, its not an MOU but a long term strategic co-operation framework agreement and it lasts for 10 years, subject to extension and termination clauses.
They don't have the monopoly but do have the exclusive rights to act as the distributor of Fruitflow and sell Fruitflow based functional food and dietary supplement finished products in Mainland China, Hong Kong, Macau, Taiwan and Australia.
Provexis will be responsible for the manufacture, supply and sale of its Fruitflow heart-health functional food ingredient to By-Health.
What comes out of the negotiations with DSM is anyone's guess atm.

Came across that one this morning as well :)
Looks like it made reference to our own Med Hypotheses
"Platelet hyperactivity in COVID-19: can the tomato extract Fruitflow® be used as an antiplatelet regime?"

Hope this link works https://bit.ly/32Z3mxv

Study on the Effect of Tomato Water-soluble Extract Xinluosu on Platelet Function and Its Molecular Mechanism.

Can't remember if this Chinese study has been posted before but also has quite a few references to PF4.

"The level of PF4 was also reduced after Fruitflow intervention,and the difference between before and after intervention was statistically significant(P<0.001)"

"Conclusions1.Fruitflow can inhibit platelet aggregation,reduce the production of TXB2,6-keto-PGF1aand the release of PF4 stimulated by ADP and Collagen."

"Fruitflow has certain application prospects and important scientific significance in the prevention of cardiovascular disease research."

https://dysw.cnki.net/kcms/detail/detail.aspx?filename=1021699508.nh&dbcode=CMFD&dbname=CMFDTEMP&v=

He did, yes.
Let's hope he includes the benefits of fruitflow on PF4 to cover this new discovery on why the vaccine causes blood clots.

This other Chinese study also refers a lot to PF4
https://www.researchgate.net/publication/340194606_Fruitflow_attenuates_human_platelet_granule_secretion_through_down-regulating_SrcPLCg2PKC_signaling_pathway/fulltext/5e7ce5fd458515efa0ad6b2e/Fruitflow-attenuates-human-platelet-granule-secretion-through-down-regulating-Src-PLCg2-PKC-signaling-pathway.pdf

"Fruitflow inhibited platelet surface expression of CD62P, CD40L, and CD63. Moreover, agonist-induced release of platelet factor 4 (PF4)"

Can only be a good thing.

No, nothing major found in the US.

This is another.
"Effect of tomato, lycopene and related products on blood pressure: A systematic review and network meta-analysis"

"Subgroup analysis in hypertensive patients showed that STE significantly reduced both SBP and DBP with pooled MDs (95% CIs) of –8.09 (–11.52 to –4.67) and –4.25 (–6.97 to –1.53) mmHg, respectively, compared to placebo. Other forms of tomato, including other dose ranges of standardized tomato extract, tomato-containing diet, lycopene-free preparation, and synthetic lycopene, did not show consistent and significant effects on either SBP or DBP in all analyses.

Conclusion
Standardized tomato extract (STE) significantly decreased SBP compared to placebo in a mixed population of healthy volunteers and hypertensive patients. The BP-lowering effect was more pronounced among hypertensive patients. No significant BP effects were seen with other forms of tomato, lycopene and related products in the overall population or any subgroup of the population.
https://www.sciencedirect.com/science/article/abs/pii/S0944711321000544

Not just the Chinese that are doing studies.......

Fruitflow is included in this Pharmacological Research Review but unfortunately its a pay to view.
"The current use and evolving landscape of nutraceuticals"
https://www.sciencedirect.com/science/article/abs/pii/S1043661821005855#!

A google search brings up.....

The Current Use and Evolving Landscape of Nutraceuticalshttps://www.sciencedirect.com › science › article › pii
5 days ago — One such example of a successful product is Fruitflow® manufactured by Provexis. ... ScienceDirect ® is a registered trademark of Elsevier B.V..