Member Info for gixer

Either way I think we should be due an RNS on the 31st for the first payment of stock.
We know its happening but don't know the value and may be classed as a "Substantial transaction"

But....... wtfdik :)

"Substantial transactions
12. A substantial transaction is one which exceeds 10% in any of the class tests. It includes
any transaction by a subsidiary of the AIM company but excludes any transactions of a
revenue nature in the ordinary course of business and transactions to raise finance which
do not involve a change in the fixed assets of the AIM company or its subsidiaries.
An AIM company must issue notification without delay as soon as the terms of any
substantial transaction are agreed, disclosing the information specified by Schedule Four."

"“When a person eats foods rich in choline, phosphatidylcholine and L-carnitine, the gut microbiota creates TMA, which the liver then turns into TMAO. But by modulating the gut microbiota with the plant polyphenols in Fruitflow, less TMA and TMAO is produced – conferring a cardiovascular benefit,” Steinert says."

Kind of like a flood barrier then. Or more accurately, stopping the flooding in the first place.

Everhopeful, The results of the clinical trial, found that four weeks of supplementation with Fruitflow decreases fasting blood and urine trimethylamine N-oxide (TMAO) levels.
It is your choice if you wish to believe that High TMAO levels do not have a connection to cardiovascular events but many studies have shown that TMAO is involved in the occurrence and development of atherosclerotic diseases through various mechanisms.

"Higher levels of TMAO have been linked to adverse cardiovascular events."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969508/#:~:text=Recent%20evidence%20has%20shown%20that,pathogenesis%20and%20increases%20cardiovascular%20risk.&text=Previous%20studies%20have%20suggested%20that,elevated%20levels%20of%20TMAO%20precursors.

https://www.karger.com/Article/FullText/520910

https://pubmed.ncbi.nlm.nih.gov/36593094/#:~:text=Conclusions%3A%20High%20levels%20of%20TMAO,in%20patients%20with%20atrial%20fibrillation.

etc. etc.

Nice finds again Dr_H and a good start to the week from DSM. Long may it continue.
Would have been nice if Provexis got a mention in the articles but sales of FF is what counts for the short, medium and long term.
:)

Yes it was posted a while back but just thought it was more relevant now.

DSM snippets continued.
BioCare from DSM

"Health from the gut is the gateway to overall health"
https://www.biocarecph.com/en_us/home.html#:~:text=Health%20from%20the%20gut%20is%20the%20gateway%20to%20overall%20health&text=DSM's%20Targeted%20Health%20Solutions%20include,solutions%20that%20take%20you%20further.

"Feed your gut for metabolic health"
"Cardiocare
Selected probiotic strain with bile salt hydrolase (BSH) activity impacting cholesterol levels1, vitamin B1 and Fruitflow®. Fruitflow® is a bioactive anti-thrombotic tomato concentrate to help maintain normal platelet aggregation, which contributes to healthy blood flow. Vitamin B1 contributes to the normal function of the heart."

https://www.biocarecph.com/en_us/product-concepts/metabolic-health.html

DSM snippets. (no mention of FF but)
"DSM partners Sun Genomics precision probiotic brand Floré"
By Nikki Han****s

12-Jan-2023 - Last updated on 17-Jan-2023 at 20:45 GMT

"In the coming year, DSM will launch Health from the Gut (HfG), a redefined health benefit platform for its dietary supplement customers.

"The new platform will lead the way with an innovative range of purpose-led and personalized solutions that enhance gut health to support immunity, digestion, brain health, stress management, metabolic health and more," ?adds Porter.

"This pioneering platform will leverage DSM’s full capabilities across not only high-quality products such as probiotics, but with premix and market-ready solutions that can be personalized for a range of consumer groups to fast-track our customers’ innovations?.""
https://www.nutraingredients.com/Article/2023/01/12/DSM-partners-Sun-Genomics-precision-probiotic-brand-Flore

DSM's Health from the Gut Solutions at Probiota 2023
February 6-8, 2023
Barcelona

https://www.dsm.com/human-nutrition/en/events/dsm-at-probiota-2023.html

Asim will deliver Keynote speech in Kolkata on Development of Fruitflow. At the International Conference on Recent Advances in Health Science and Technology
27th and 28th of January, 2023

https://www.facebook.com/photo/?fbid=10227796580595208&set=a.1539160114179

https://icrahst.com/

Some snippets.
https://www.atlantiaclinicaltrials.com/publication/gut-heart-axis-opportunity-revealed-in-natural-product-rich-in-polyphenols#Over

https://twitter.com/AtlantiaT/status/1616418188786388993

https://www.linkedin.com/search/results/content/?keywords=fruitflow&origin=FACETED_SEARCH&sid=bLy&sortBy=%22date_posted%22

https://www.facebook.com/asim.duttaroy/posts/pfbid0RhhtWXUjntLouN8a25aJBQC16JpvcBQPvEsoqdBihBYvzsJfyxTh3XBPEvdV5YVXl?__cft__[0]=AZVDBEIQcm2JkqJRywRQRE8FZKH4JvB3dkdEkyuzF4YFlT_9tLfwNIF0eGzIZs7Jf02oFCmRNZ-_7wPFPde0WdOv3VwHu9jmEAbxcrBOY7EF1A&__tn__=%2CO%2CP-R

By-Health have a patent for
"Water-soluble tomato extract with function of improving memory and application thereof"
https://patents.google.com/patent/CN114617920A/en?q=%22water+soluble+tomato%22&oq=%22water+soluble+tomato%22&sort=new

but we don't know if this study for DSM was ever completed.
Cerebrovascular and Cognitive Improvement by Resveratrol (resVida) and Fruitflow-II (CCIRF-II) (CCIRF-II)

https://clinicaltrials.gov/ct2/show/NCT01766180

Great find Dr_H and nice to see that DSM found it important enough to issue a press release.

Would have/would be a good fit in a few i-Health brands of DSM
https://www.dsmihealth.com/our-brands

Maybe they are saving FF for Gut Health?

https://www.hologramsciences.com/solutions

https://aim-watch.com/project/bid-ask-spread/#:~:text=A%20large%20spread%20is%20also,ask%20spread%20widen%20quite%20dramatically.

DSM's current stock expected to be in excess of €1m (£886,906)
Cash in bank at 30 September 2022 = £745k
How much stock we will buy and therefore how much cash might be needed is still unclear so would like to think that we would get an RNS on or just after 31-1-2023 when the first payment is due.

Just remember its stock we are buying and it will be sold at a profit.

That one was an official press release from By-Health.
http://www.by-health.com/news-4588

In the following link the top word is Provexis's trademark for Fruitflow. As David says "QINGLUOSU"
The bottom is By-Healths Trademark for a product that contains Fruitflow and I believe something else (I forget what),XINLUOSU, and it was originally the name of a sports product that was going to launch back around 2017 before all the regulatory work started.
https://translate.google.co.uk/?sl=auto&tl=en&text=%E8%BD%BB%E7%BB%9C%E7%B4%A0%0A%E6%96%B0%E7%BB%9C%E7%B4%A0%0A&op=translate

Here is the one I was thinking of.
Date of Last Refreshed on:2022-11-16

https://www.chictr.org.cn/showprojen.aspx?proj=129186

Hi Dr -H, yes and there is another similar to this that has been updated recently but not on my p.c. atm to provide the link.

I wondered, because of the date in the link I posted, whether it may be the trial starting up again after Covid.
Just a guess though.

Not sure what this one is about because, as you see, data is limited. It is to do with B-H & FF though.

https://www-medresman-org-cn.translate.goog/pub/cn/proj/projectshow.aspx?proj=9895&_x_tr_sch=http&_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=en&_x_tr_pto=wapp

I fear the funding of such a study may be a little beyond our reach ATM.
However, it wouldn't surprise me if By-Health had something up their sleeve.

"COVID-19
Fruitflow was recognised in a review article by the Frontiers in Nutrition journal
www.frontiersin.org/articles/10.3389/fnut.2020.583080/full in 2020 which stated that nutraceuticals such as
Fruitflow may serve as: ‘A safe antiplatelet prophylactic treatment for those at high risk of COVID-19 who may also be at increased risk of thrombotic complications and an alternative to pharmacological compounds that may cause greater risk of bleeding.’
A review article, titled ‘Platelet hyperactivity in COVID-19: Can the tomato extract Fruitflow® be used as an antiplatelet regime?’ www.sciencedirect.com/science/article/pii/S0306987720333715 was published in 2021 by the peer-reviewed journal Medical Hypotheses, a leading journal which advances new discussion and innovation in medical treatments.
The article was written by Professor Asim K Duttaroy, the original inventor of Fruitflow, and Dr Niamh O’Kennedy, Provexis plc’s Chief Scientific Officer, and it concluded with the suggestion that:
‘Consuming Fruitflow®, especially before or during the early stages of COVID-19 illness, may have an effect on the severity of illness experienced. It may particularly benefit people who are more vulnerable to the development of endothelial / platelet dysfunction. It is a safe dietary antiplatelet and should be investigated as a potentially useful intervention for prevention of thrombotic disorders in COVID-19."
https://www.provexis.com/wp-content/uploads/2022/12/Provexis_plc_30-Sep-22_interims_30-Dec-22.pdf

Might be of interest????
https://www.linkedin.com/feed/update/urn:li:activity:7017247031559606272/?updateEntityUrn=urn%3Ali%3Afs_updateV2%3A%28urn%3Ali%3Aactivity%3A7017247031559606272%2CFEED_DETAIL%2CEMPTY%2CDEFAULT%2Cfalse%29

https://maryannedemasi.substack.com/p/lancet-opens-investigation-into-anti