Lupuzor compared with Humira??!2 Sep 2025 18:25
Tim compared P140(Lupuzor) to Humira ( Adalibumab) during the interview today which seems to be generating excitement.......?
As a pharmacist I'm grateful for summaries posted here re financial position, patents, funding etc so trying now to consider this comparison. Using ChatGPT( for ease ) somewhat but will interpret as someone who works with current immunomodulator treatments in gastro..
Lupuzor® (also known as P140 peptide or Forigerimod) is an experimental treatment for systemic lupus erythematosus (SLE) with a novel immunomodulatory mechanism of action.
how it works, based on preclinical and clinical research:
🔬 Mechanism of Action
-Targeting Autoreactive T cells
In lupus, autoreactive CD4+ T cells drive autoantibody production by B cells.
Lupuzor binds MHC class II molecules (mainly HLA-DR) on antigen-presenting cells.
This interaction selectively modulates autoreactive T-cell responses.
- Induction of T-cell Tolerance
Instead of broadly suppressing immunity, Lupuzor induces anergy (non-responsiveness) in pathogenic T cells.
It reduces the secretion of inflammatory cytokines (e.g., IFN-γ, IL-10, IL-21).
This prevents overactivation of B cells and reduces pathogenic autoantibody production (e.g., anti-dsDNA).
- Restoring Immune Balance
The peptide shifts the immune response toward regulatory pathways, sparing normal protective immunity.
Unlike corticosteroids or immunosuppressants, it does not cause generalized immune suppression.
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🧾 Summary
Lupuzor acts as an immunomodulatory peptide that binds MHC class II and induces tolerance in autoreactive T cells, dampening lupus-related autoimmunity without broadly suppressing the immune system.
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Interpretation:
Key point it's that it SPARES normal immunity/restores immune balance rather than causing general suppression.
Humira is an anti TNF (tumor necrosis factor) agent which blocks TNF alpha protein to reduce inflammation.
There are MANY of these agents on the market, not just Humira, eg infliximab , so the novel mechanism of P140 stands out as a new class of agent to me(with 20 year patent protection). It is dissimilar to Humira in a positive way as a "me too" amongst other anti TNFs!
This is truly exciting IMO wrt potential therapy developments in autoimmune disease (and the diagnostics element to add!)
Given there have already been trials using Lupuzor and it was shown to be very safe,(just not effective enoughas dose too low) it may just need some excelerated trials to confirm optimum use in patients. Maybe the Big Pharma themselves can perform these , following a deal, to show P140 place in global therapeutics?
I'm a LTH. That interview was the most promising I've heard in years..... GLA.
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