Member Info for EmeraldCarrots

Quickly finding out if a subject in a cancer drug trial is responding to the drug OR NOT offers the chance to remove that person from the trial and offer alternative treatment. DOES IT NOT. Could save their life.

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The obvious way it should happen.

1. Organize cancer drug trial to see if the drug works.

2. Ask Angle to develop an assay to test x in the circulating tumour cells (CTC's). These are actual cancerous cells originating from a tumour. Therefore, they will react to the drug same as the cancer (they are the cancer!). Note the Plc doing the trial will know how they expect the drug to work, so they will know what to test in the CTC's.

3. Do the trial, getting Angle to test the subjects before, during and after the trial (via simple blood draw).

4. Angle advise the Plc doing the trial how the CTC's responded.

All IMHO

The obvious way it should happen.

1. Organize cancer drug trial to see if the drug works.

2. Ask Angle to develop an assay to test x in the circulating tumour cells (CTC's). These are actual cancerous cells originating from a tumour. Therefore, they will react to the drug same as the cancer (they are the cancer!). Note the Plc doing the trial will know how they expect the drug to work, so they will know what to test in the CTC's.

3. Do the trial, getting Angle to test the subjects before, during and after the trial (via simple blood draw).

4. Angle advise the Plc doing the trial how the CTC's responded.

What happens.

1. Organise cancer drug trial to see if the drug works.

2. Decide paying Angle to do an assay and get back live data as the trial progresses is not worth the expense as we are only a multi-billion £ Company and our shareholders want big dividends. No morals don't care.

3. Wait to speak to the subjects over the coming months. See who is cured, who lives longer than previously expected, and who dies and when.

The people that make these sorts of decisions should be ashamed of themselves.

All IMHO.

The management taking their foot off the accelerator as far as promotions go. We had a flurry of events, interviews etc.. then next to nothing after the placing. However, I like to at least think that rather than spending time flying to events etc. they are busy with more important things. At least with the Astrazeneca contract at last a major Plc finally is looking to use the information from circulating tumour cells to monitor a cancers response during a drug trial. This is what the Androgen Receptor1 (AR) detection assay RNS was about.

When this assay is done Angle will be able to also sell it to other Plc’s to use in their drug trials. I find it astonishing that this was not happening more than a year ago. For more than a year any Company doing a cancer drug trial (especially involving metastasized cancer) have had a way (if they pay for an assay development) to monitor how their expensive drug affects the cancerous cells. The only other way as far as I know is to wait far longer to see how the patient actually responds, or not. One can only assume it is the cost of developing a suitable assay that is preventing investment in this totally obvious advance in cancer research. Scandalous IMHO.

All IMHO.

https://www.lse.co.uk/rns/AGL/new-commercial-agreement-with-large-pharma-gvzk9wgh1la0ljx.html

Up 2.04%.

The drop seems completely overdone. It held 55p ish until the afternoon when the sp dived again. USA investors selling out? I am expecting the sp to move back to the mid 50's very soon.

Https://jeccr.biomedcentral.com/articles/10.1186/s13046-024-03149-x

The amazing lack of RNS's over the last few months. To be honest I am astonished and bewildered. I am also astonished and bewildered about the Pharma Co's reluctance to analyse circulating tumour cells to get immediate feedback on how their new cancer drugs are doing during cancer drug trials. Angle can give them this information, if they pay.... They seem to more used to waiting much longer to see how the patients feel, if they recover or how long they last until death. I find it totally astionishing. No wonder cancer research is so slow. How on earth do the people that organise cancer drug trials, so far, NOT do the obvious? MONEY, or are they so set in their ways they can't change? Very SAD.

All IMHO.

Correction. Added:- ***when testing new cancer drugs***

To be the only companies that have contracted Angle to analyse the circulating tumour cells Angle's Parsortix machine can catch. Note Angle's Parsortix machine catches circulating tumour cells that are still alive, so perfect for analysis. Studies have shown CTC's are likely to show the status of a person’s cancer. Only THIS YEAR have these Companies finally decided to invest in this obvious potential ***when testing new cancer drugs***. At least Astra and Eisai have finally made the decision. What is heavens name is wrong with all the other massive Pharma Co's. I mean, are they all waiting for another Company to spend the money? It's scandalous.

All IMHO.

To be the only companies that have contracted Angle to analyse the circulating tumour cells Angle's Parsortix machine can catch. Note Angle's Parsortix machine catches circulating tumour cells that are still alive, so perfect for analysis. Studies have shown CTC's are likely to show the status of a person’s cancer. Only THIS YEAR have these Companies finally decided to invest in this obvious potential. At least Astra and Eisai have finally made the decision. What is heavens name is wrong with all the other massive Pharma Co's. I mean, are they all waiting for another Company to spend the money? It's scandalous.

All IMHO.

Like the other machine?

Any Medic that deals with stroke victims anywhere in the World would benefit having this machine to use.

1. Gives the result in about an hour (as opposed to sending off blood to a lab and waiting a day or more).

2. Does NOT need a blood draw, just a cheek swab!!! I mean how easy is that!

3. In fact is CHEAPER than using a lab according to NICE!

If this machine does not seel like hot cakes I don't know what will.

All IMHO.

As sales increase to more trusts word will get around that the machine:-

1. Gives the result in about an hour (as opposed to sending off blood to a lab and waiting a day or more).

2. Does NOT need a blood draw, just a cheek swab!!! I mean how easy is that!

3. In fact is CHEAPER than using a lab!

I rest my case!!!

Maybe I should buy some more??

All IMHO.

Probably won't go over 5p just yet. Probably.

Https://www.england.nhs.uk/publication/nhs-provider-directory/

I make is 214Nr. trusts in this list.

Just a few orders from ANY trust other than Manchester, where the machine was tested before the NICE recommendation.

So what is the betting?

All IMHO.

Https://www.england.nhs.uk/publication/nhs-provider-directory/

To start the ball rolling an RNS to say another, or x amount of new NHS trusts have now placed orders for the Genedrive machine. Seems pretty obvious they will. Can't be long now.

All IMHO.

One or more of the NHS's trusts placing oderes for the new machine would be nice. No, wonderful! it's got to happen. Just when.

All IMHO.

Analysis of cancer, especially in the USA) seemingly, NOT do anything regarding Angle Plc's RNS of 4th Jan 2024!!! The RNS shows that catching (with Angles Parsortix machine) circulating tumour cells (CTC'S) and analysing them at the same time as general CtDna found in blood gives additional actionable information to do with the cancer!! This is IMPORTANT! This could be added to Illumina's CtDna package so both the CtDna AND the CTC'S are sequenced giving the full picture (showing mutated cells in both CtDna AND CTC's). In my opinion Illumina are (apparently) failing to move forward in the battle with cancer. What is the matter with them?

https://www.lse.co.uk/rns/AGL/breakthrough-clinical-results-b0km788ah9aflqm.html

All IMHO.

Oversold IMHO!!!!

Meeting market expectations in yesterdays results. Presume the outlook went down like a lead balloon? Amazing. I am shocked.

Expectations? Astonishing.