RE: New clinical trial14 May 2025 14:00
Well found Samsmith.1800.
450 participants. And Parsortix involved. A fair bit of money. I looked up this "Double-positive Circulating Cells (Tumor Marker / CD45+)" and AI came up with this:-
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Double-Positive Cells:
The combination of CD45 and a tumor marker on the same cell suggests a cell with both immune and tumor cell characteristics. These cells may be derived from the fusion of tumor cells with leukocytes or represent a unique type of tumor cell that has acquired leukocyte markers, potentially influencing its behavior and metastasis.
Clinical Significance:
Research indicates that double-positive circulating cells, especially those that are CD45+EpCAM+ or CK+/CD45+, are associated with poor prognosis in some cancers, like NSCLC and breast cancer. The presence of these cells may be linked to increased metastatic potential, resistance to therapy, and the formation of a hostile tumor microenvironment.
Potential as a Biomarker:
The detection of CD45+ tumor cells in the blood could potentially serve as a non-invasive tool for early cancer detection, monitoring treatment response, and predicting prognosis. Studies are ongoing to further investigate the clinical utility of these cells as a biomarker in various cancer types.
In summary, double-positive circulating cells (CD45+/Tumor Marker+) are a unique population of circulating cells with a dual identity that can provide valuable insights into cancer biology, prognosis, and treatment strategies.