Member Info for D-Geeman

Cheers Phil, thank you for that.

After I posted my request I recalled email alerts (for eve sleep, so a long time ago) once upon a time from London Stock Exchange. I think that's what you mean though you might have meant this site, LSE (London South East). They might do something similar?

Anyway, I will log on to LSE (The stock exchange)as I should still have an account and request emails from now on.

I will miss the phone pings at 7am (though I doubt that there'll be one from AVCT tomorrow due to the curse of Watching2's prediction :-)

I've received the email below. Are there any free alternatives for alerts that people are aware of?

'At V o x Markets, we have always been committed to delivering free real-time RNS alerts to investors like you. Unfortunately, due to rising licensing fees from the London Stock Exchange and increasing server costs, we are now required to introduce a small monthly

fee for this service.

To make this transition as smooth as possible, we are offering an exclusive Early Bird rate of just £3.99 (ex VAT) per month for those who subscribe before March 1, 2025. After this date, the price will increase to £5.49 (ex VAT) per month.'

On X just now, from TLSA (progress update ‘soon’ on patient Joe.) ;

‘ Thank you @WCVB for interviewing Joe and his Wife Karen during treatment with intranasal foralumab for his moderate Alzheimer's Disease. We hope to provide you with an update shortly with Joe's progress. $TLSA #Alzheimers

youtu.be/vj6GGzbJfOk?si…

tizianalifesciences.com/tiziana-life-s…’

'Sorry', not 'sore' :)

Feeling a bit sore for Ben I found (but didn't read):

Tectonic Therapeutic Announces Positive Interim Data from Phase 1b Trial for TX45 in Patients with Group 2 Pulmonary Hypertension in HFpEF

The interim results from the Phase 1b open label clinical trial are based on 16 of 19 enrolled patients with PH-HFpEF, with the remaining 3 patients currently completing Part A of the protocol. Within the 16 patients in the interim analysis, 9 patients had CpcPH, as measured by PVR>2 Wood units.30 Jan 2025

https://investors.tectonictx.com/news-releases/news-release-details/tectonic-therapeutic-announces-positive-interim-data-phase-1b#:~:text=The%20interim%20results%20from%20the,by%20PVR%3E2%20Wood%20units.

And

https://academic.oup.com/jscd/article/1/Supplement_1/yoae002.006/7686710

Interim Results of a Phase 1b Study (PIONEER) of an Oral HbF Inducer, Pociredir, in SCD

+16.28%

I think Ill be buying on the dips rather than risk being out at this rate..

I missed the 2nd RNS initially. Bought back in now as too painful to be out. Wouldn't be surprised at a pull back now, to spite me, but hopefully they were telling the truth in the interview. It was my question "previous information from the company in the past has been wide of the mark" to which the CEO replied was fair comment. He seems to be a straight talker so I should be ok.

I've got another share (TLSA), moved to Nasdaq and I think fair to say that investors have been extremely disappointed in the last few years since leaving London. They have a lot less to trumpet than AVCT yet today put their first trial patient – and wife – on TV for an interview and said early results look promising, even suggested more people to volunteer for the Alzheimer's trial.

What's stopping AVCT doing the same now?

Tiziana Life Sciences Announces TV Interview

https://www.lse.co.uk/ShareChat.html?ShareTicker=TLSA.US&share=Tiziana-Life-Sciences-Ltd

Joe and his Wife, Karen, shared their journey and shed light on the hope that innovative therapies like Foralumab offer for individuals battling moderate Alzheimer’s, a condition that currently has no cure and limited treatment options.

NEW YORK, Feb. 11, 2025 (GLOBE NEWSWIRE) -- Tiziana Life Sciences, Ltd. (Nasdaq: TLSA) (“Tiziana” or the “Company”), a biotechnology company developing breakthrough immunomodulation therapies with its lead development candidate, intranasal foralumab, a fully human, anti-CD3 monoclonal antibody, today announced that its investigational drug, intranasal foralumab, was featured on a prominent News Channel. The segment highlighted the experiences of the first patient dosed in the company’s expanded access program for moderate Alzheimer’s disease.

In the segment, Joe and his Wife, Karen, shared their journey and shed light on the hope that innovative therapies like Foralumab offer for individuals battling moderate Alzheimer’s, a condition that currently has no cure and limited treatment options.

Watch the full interview here: https://youtu.be/vj6GGzbJfOk?si=lMqkFipmll8GF--o.

Dr. Howard Weiner, Co-director of the Ann Romney Center for Neurologic Diseases at Brigham and Women’s Hospital, a founding member of Mass General Brigham healthcare system commented “Foralumab, administered via a novel intranasal delivery method, aims to target immune system dysregulation associated with Alzheimer's disease, potentially slowing disease progression and improving cognitive function. The recent coverage in the News underscores the growing recognition of Foralumab's promise in the field of neurodegenerative diseases.”

Foralumab’s mechanism of action involves modulating the immune system to reduce inflammation, which has been linked to neurodegeneration in Alzheimer’s. The expanded access program enables patients who do not have access to clinical trials to receive this promising treatment as part of a compassionate use initiative.

Yes, still in HE1. A good day there but I dint follow the board much now. Either I will lose what's left or they find a commercial amount and my remaining balance will multi-bag and be in profit.

I have been taking profits whenever possible of late (new style) but have missed out on bigger gains :-/ when momentum has carried on.

The 'Estate of William Black' also made me think they will want to shift a lot of stock if the price rises. Having lost in the past I was too cautious I now think.

(Off topic I know but ICE's sums do read well.. Didn't want to post as everyone is looking for a motive in any post. Fingers crossed.)

Thanks Wyn, I have been following the RSI and I know it fell back for the week / day, but month was still high. I'm up on my first (recent) purchase but sold some at that profit...

As you say, all a gamble.

Wyn, isn't the RSI still a bit high looking at 30 days?

'why on earth does anybody take the slightest notice of wyn'

Yes safebreaker, why on earth. He's been banging on since the SP was at least 200p, and that was years ago.

I will tell that to my daughter Touk! (Part 2 tonight :)

Have you read this anecdote repeated in Alan Clark's diary (and elsewhere)..

'Apparently Bader was asked to take part in a debate at a respectable girls' school and at some point during the proceedings, recounted one of the times when he was shot down over the Channel:

''...And my engine was on fire, I had two of the f uckers on my tail, one f ucker was coming up at me from the left and there were two more f uckers about a hundred feet above me waiting for...' (At this point the headmistress panicked and interrupted. 'Girls, as of course you all know, there was a type of German aeroplane called the FOKKER.') But Bader: 'I don't know about that. All I can tell you is that these chaps were flying Messerschmitts"'

Watching2: I thought of you last night when Douglas Bader (before crashing in 'Reach for the Skies'; another classic film with insomniac daughter) shouted "Hang on to your hats" – which sounds better than "hold on to your hats" imho.

'Sugar is not a carcinogenic (cancer-causing) substance. However, over-consumption of sugar, particularly added sugars in processed beverages and foods, can contribute to obesity which is an important risk factor for cancer. There is no evidence that consuming sugar makes cancer cells grow faster or cause cancer.'

I wasn't talking about artificial sweeteners, only free sugar. You implied it causes cancer (that's what I inferred you implied anyway) but and I don't believe it does anything other than make one obese (which then causes other problems I agree) and rots your teeth.

'recovered chat board addict'.. Remission perhaps but recovered, no.

I nearly joked last week that Ice was being too successful with his figures for the future share price. If each of our shares are going to be worth £20+ then why buy anymore, just in case the opposite happens. Presumably many people on this board would be millionaires if this 40-80 bags from here. That's enough surely. Why risk more of your (presumably hard earned) cash.