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I dont think its anything to do with wether an nda is in place or not. Surely to give a positive update that things are being planned out and the submission is on track is nothing to do wether there is an nda in place or not...too someone looking in, the current situation looks like GL is not confident on approval....why would anyone invest now!

Amphion included mtfb in a release this morning but im not sure it means, their keeping their holding anyway and those more versed will understand it im sure. I don't know what GL is playing at here buts its laughable being so close to decision time and him not updating the market on what the future holds if at all...not very reassuring in troubled times i must say!

Actually, it is an interesting point. I did previously wonder to myself if there was an opportunity presenting itself for a management buyout? Australia is full of multi millionaires and the original inventors must be worth a few bob, they would have no trouble drumming up investors if they wanted it that way...ofcourse, that would mean getting the mc as low as possible so an offer to shareholders would look attractive at that point...i dont see how anybody could stop them because they would soon get the big boys on board. Jack is the fly in the ointment there though because if they were going to try that, they would never have appointed him....or maybe they want a big placing out the way first! Ive seen a few dodgy ones go through recently so nothing would surprise me. Nice opportunity for jack to buy in cheap anyway:)

I can look back as far as 2015 to say that the companies communication has been very poor, what bothered me then was that people on this board would find out market sensitive info days before SEE released the information, if they did even bother too in the end, i think sometimes they felt, well the info is now out there, why bother. However, it would seem in the last 6 months or so that they have went out their way to disengage with shareholders. Something seems to have irked them and maybe it was the response to the performance shares or maybe they have never liked the fact that shareholders have been too intrusive into the business or too demanding off them. Whatever it is, ken now really seems like he is disenfranchised with it all and really...i think he will probably call it a day at some point, lets see!

Hi jt, Yes they have and these options are excercisible at 0.25p...so im not worried, im crapping myself...hahaha. That must have been some session you were on yesterday if you were in that nick at 8pm.....used to love my friday nights, oh the good old days:)

Hi ahfam, i think we can now safely say that there was nothing tangible for us with wh ireland being dropped as co broker, they have been nomad for ages. We did think at the time that it might have signalled something but thats long past and on the contrary, they even went external for the placing so maybe it was a negative as it turned out. At this stage, i would never deny sars potential and i have always maintained, anything could happen at anytime, thats why i will hold as long as i can. However, that aside...we need tangible action from the bod to support our position! Its not good enough to have licence deals in place and still doings placings at massive discount after 14 years on the go and no matter how we dress it up, the risk is there...wether aurora has value or not, its a good example of how things can go wrong, even when it was with hmbec we spent a lot of money on it through the cro's. In 2011 we all thought that Aurora was our number one, 7 years later and its effectively shelved and during that time our sp hit 0.018 and we had a massive placing at 0.025. I dont want to be going back there again but the market seems to be preparing itself for a difficult time and without solid progress, further placings could see us in rocky waters so our bod should be acting now imo. That is, unless they are quite happy to roll along and take the money...their last options have a 2026 expiry so maybe they feel they have plenty of time. I don't...sob sob sob:)

Sar wont let anything slip at the agm, im sure of that...they dont give anything away in their market updates so you can be sure they will shut up shop during the questions if many are put. Thats fair enough but im hoping (and its a bit rich coming from me since i cant attend) that those who do attend are able to push them on where we are as shareholders. Not everybody is in agreement and some are happy to wait and hope for a good outcome but im becoming very concerned at the timeline...we waited more than 7 years for trial approval for chk1 and the timeline since then just shows that even when you can get these drugs into trials, it can take a long time to even get through a phase one, things can change and the risk is really only just beginning at that point. I said before that i would like them to sell either chk or tyk and pay a divvy if sale was large enough but i know thats highly unlikely, it would not suit the bods self interest unless they took up their options quickly so i dont see that as a possibility really. I am hoping for an outright sale of all, that is obviously a selfish point of view but the alternative is where we have been for years. If things dont go our way with chk1, efficacy/milestones etc, if things dont go our way with tyk2, timeline/approval/deal etc...in 2 or 3 years, we could still be in this position of hoping for a break with an sp of 0.25...we should not be so confident this can't happen, take a look at others around and the sp history of sar itself, the risks are far greater than the possibilities imo. This is the risk we have taken ofcourse and imo, its not directly the bods fault if we fail...this is worldwide highest scalr complex stuff they are dealing with so we cant complain if it fails. However, if theres an opportunity that presents itself for us to make money then they must take it, that is the responsibility they accepted when the company was floated...so im hoping one of the attendees who thinks along these lines can get this point across, it might be met with deaf ears ofcourse but what can you do...either hold or sell. Sorry if a bit negative but im no longer blinded by this great opportunity..my thinking is now more focused on a timeline that could easily run away from us and the risks associated...i think the last 10 years proves that things are never straight forward. Good weekend all anyway....from the miserable one! Sorry dave but im the new victor:):)

Hope you are well thoth? Any news on nicholson, he's not going to be sitting on hands for long but what will he do, where will he go? I would be surprised if you are not tracking him:)

Excuse me aber...i think you will find that i put a smile at the end of that statement, meaning it was just a little joke:) Im in agreement though, its been a rubbish year being a sar shareholder really. Not much tangible progress with chk1 and a bit of confusion with exactly where we are with it and where its going, hence no milestone and the srra sp being a bit worrying. Getting aurora back then putting it on hold and then tyk2, candidate selection coming a bit later than we thought and no deal behind it as we hoped there might be. There's also been the parker buy which caused some confusion and the unusual placing followed by a significant sp drop so its hardly surprising that sentiment has taken a nose dive. Its made a lot worse because most holders on this bb have been here for a lot of years and they think...ok, maybe this coming year could be it and.....but it never seems to happen! Do we think it ever will, its a fair question but even if the answer is yes...when is the more worrying point? Chk1 was approved almost 3 years ago, ct started 2.5 years around the same time as the srra deal, for sure we are a lot further forward but it does not seem like it and the market is not only shrugging it shoulders, its sticking 2 fingers in the air at us:).

Anybody following the rns of roche just now, they are just bashing out updates one after the other re their cancer portfolio and its success after success. For me...its another reason why i hope the bod are looking to derisk, the space is getting quite crowded and these big boys have a lot of clout. Come on sar...time to get a move on, one way or the other!

Lets hope so searle but where is that tyk2 patent. Would be nice if it were like the bus scenario, wait for ages then 2 come together....merry xmas and lets start the new year ready to rock n roll!

Somebody got out of bed on the wrong side this morning aber:) Jazzman...you have missed lots of price monitoring extensions, a few placings, the odd update via results and a bit of twitter activity! Not that much really but you had to be there to appreciate it.....so i trust you will pay more attention going forward:):)

A few more of them 1m buys would perk up the day. C'mon...we have not had a rush for a while, lets see some action:)

Who knows rayboy, maybe we dont want to be snapped up:) We are a mere minnow compared to tesaro and gsk going for them is a real statement of intent and firmly answers the question on why they went for hal barron to begin with. Will they continue bolstering their pipeline, you would have to think yes, m&a in the market is good for us anyway. The question is, do we have a seat at the table, are we in the mix?

Have just announced that they are buying tesaro for 5b. So, thats them made their big move into the oncology scene.....any thoughts?

Thanks for posting donald. All positive and another pre clinical study with another top university involved which bodes very well...sierra are really pushing the boat out here and something has got to give soon i think re the existing clinical trials. There's so many things going on with chk1 & etc etc....im getting lost exactly where we are with what but i was never that good at truly understanding the science or jargon. You would have to think that by now they have got some further efficacy data also on the human trials and if good, we can hope for some media exposure or a substansive update from sierra on that. Anything could come out of the blue at anytime i think and given that the toxcity is well within the safety parameters...good or impressive (and im not saying striking) efficacy results would shoot chk1 up the ratings board pretty quickly. Lets hope so:)...some good news would be more than welcome!

Hi tricky, i have never done but you wont lose full spread. The same mm will do the transaction at a very limited spread so he will make 50-100 quid out of it, thats my understanding anyway....no-one would transfer if it was full spread loss. Aye up lads...nearly december, the month of the Sar:)

My average is high because of a very big buy i made at 2.10...before that my average was very low and i managed to get it back down by buying through the ya drawdowns and at 0.2 after but not a good time was that! Im just disappointed to see its bigger than i thought but its not all bad though. The money to buy at 2.10 came from gkp and if it had stayed there it would be virtually worthless now so sar have kept me in the game and a bit of good news can see us fine again. Nice position to be in jt.....lucy would be impressed:)

My average just under 0.77, i never worked out before but had it in my head it was around 0.7...dunce! We could do with a leak or a daily sport article...eh jt:)

Not picking up anymore...ive just decided to cancel christmas! I log into my trading account every now and then, just to have a look at live trading prices usually. I never go into the holdings table part...anyway, iii used to base your value part on the mid but they have changed it to the bid (quite rightly) and i was shocked to see how much im in the red...i thought i had a better average than i have, for a long time it showed green but the traffic lights are firmly on red now. Heyho...you can **** off santa, the well is dry! You've been quiet lately minden:)