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Neither Thornogson/NDN/Eggy nor the pub windbag are invested. Their sole reason for existing here is to trash Avacta.

The ToucanOfDoom is just very angry at being spiked yet again.

Just a reminder that Toukankahmoon is angry because he got spiked, twice.

The troll Thornogson/NDN/Eggy is nothing if not versatile ...posting here whilst skiing down some foreign slope. But then everything he writes is a lie so he's really in his underwear in his bedroom in his mum's flat.

Just a reminder that Thornogson/NDN/|Eggy isn't invested and works for Tom Winnifrith.

Just a reminder that Thornogson/NDN/|Eggy isn't invested and works for Tom Winnifrith.

It's not about not agreeing with (although that may be the case for the more immature posters) but rather that 'a point of view' is worth nothing unless it is supported by evidence or at least a reasoned argument. Everything else is just FUD.

Hitler was another one.

Says more about the individual and their tolerance for criticism than it does about their politics.

😂😂😂

I've not noticed Trump being particularly tolerant of criticism or immune from being offended.

Yet Avacta promises the best of both worlds as the key part of Avacta's tech is the FAP-specific dipeptide substrate - the linker. And it is the linker part of ADCs that is their weakness as off-target cleaving of the linkers leads to toxicity as free warheads circulate around the body.

Just accept that you're not the great investor you pretend to be and that you got spiked - twice - and are heavily underwater. But perhaps it's pointless requesting that a narcissist (the great investor who weighs all the evidence and makes all the right decisions) can be humble enough to accept having made a mistake, or two?

Anyway, I've had enough of you. You don't have the intelligence or knowledge to make any meaningful contributions on this board. Binned.

Who cares what I think?

I was not being 'dismissive', I was seeking clarification.

The major differnce between now and when AVA6000 started is that we now have a savvy team that is experienced in clinical development. Yes, the dipeptide is specific for FAP, but AVA6103 will be a completely new and thus unknown molecule in the human body, so Avacta and the FDA will be cautious to begin with.

AVA6103 will be angled to target indications from the start, so a lot earlier than AVA6000 was, and hence will acquire more useful efficacy data sooner, but there are still unknowns that require a precautionary approach though, namely a safe starting dose (which CC talked about in that Peel Hunt interview). What that dose is, how big the escalation steps are - particularly the first one if te initial dosing is shown to be very safe, how long each cohort will take and how many cohorts get dosed will determine the end point, which is just as important as the starting point.

What lessons do you think were learnt with AVA6000 and what quantitative timeline adjustments did you make?

Avacta have project plans for each of their programmes which they've been keeping close to. Obviously not everything is under their direct control, both unexpected opportunities as well as delays. The important thing is that THEY are ready to go when external actors have done their part, such as approving an IND application. Included in the plans will be contingencies for funding, which will obviously include dilutionary options.

Best not to try to second guess what will happen or when. Either trust the management or take your money out and put it elsewhere, and TocanOfDoom, please stop TRYING to sound like a prat.

PC's could be patient cohorts, although that is not a standard abbreviation.

Do you think they would RNS an IND application submission? I don't think so, in that I'm not expecting an RNS about that but rather, some time in early 2026, an RNS announcing approval of the IND. I'm sure they are working as closely as they can with the FDA, so hopefully the approval will be straightforward - i.e. not sent back for clarification or for further data/information.

...and decent traders

Eh-up, it's eggy's gimp.

You're not invested you sad twat.

Eggy pretending he's got Avacta shares is so funny.🤣🤣🤣

Your idea to do that or TW's?

"I have my honour to uphold after all" on an anonymous BB is code for 'insecure'.

Still collecting TW's 10p's then eggy?