Member Info for bighammer

We also have Aoc3 which we basically own and also in charge of patent pending with a basic fee to pay which increases inflammation protection . I also found some sort of link involvind dc73 I think.

Still working on other research atm , but you don't spend £500000 on shares 4 days after fda approval to forward Traumakine if you are VERY confident it will work.

Zen , I am starting to get where you are coming from , I need to do a lot more research to get the bigger picture but hats off to you for the research you have done and for the heads up , cheers.

Is business on hold for a bit due to PP

This is just a rough guess , if the barrier is broken down this leads to ards and if we can treat ards then we may have found a way of stopping the barrier being broken down , and if we have this is a cause of sepsis so we could reduce the chance of getting sepsis and other possible side effects of cancer . Couple that with cleveden then you have 2 very good drugs /
If Traukamine was proven to work and as a pharmasuitical manufacturer you cancelled the agreement to produce it you would need a very good lawyer. If it can be concentrated as we think then distribution would be simple.

Not great at copy and paste but it looks like t is line up to stop the barrier from breaking down which is a side effect of othe conditions such as sepsis and trauma such as cancer .

Ok so it looks like there is a link between the 2 via the endothelial barrier which traumakine is looking to treat its a bit tecky but when breached it attacks living c
An intact layer of healthy endothelial cells is essential for normal blood vessel function. The close apposition and alignment of endothelial cells in the vessel wall accounts for their ability to form a barrier that restricts the movement of water, proteins and blood cells between the intravascular and interstitial compartments. This barrier is formed by a layer of endothelial cells that are joined laterally by cell-cell junctions, while the basolateral aspect of this layer is attached to a basement membrane composed of collagen, fibronectin, laminin, and glycosaminoglycans (GAG). Cell-surface expressed integrins, which form regions called focal adhesions (FA), bind the endothelial cells to the extracellular matrix. The resulting barrier is semi-permeable to water and non-lipophilic molecules, and is both size- and charge-selective for solutes passage.1 Precise regulation of the restrictive properties of the endothelial barrier is essential for normal organ function. Indeed, diminished barrier function (and increased vascular permeability) is associated with organ dysfunction and can lead to serious pathological consequences, as evidenced in diseases such as sepsis, as well as inflammatory and neurodegenerative diseases. Restoration of endothelial barrier integrity in these conditions can significantly impede disease progression.1,2ells but also lines the blood vessels

And as we are running more than 1 cohort against different cancers it then becomes a world wide market against cancers almost In general .

Sax , more of a morse man myself will have to have a conflab on Monday see where we have got to .

Well I have another 3 weeks spare to come up with some more ideas to keep me busy but with a bit of luck we may get some more snippets along the way.

Evening Zen , how far out were we all last night in guessing , and what other little snippets did we miss out ?

Is it that interferon beta which is used by us but also by many other pharmas but we have the patented rights to condense it into a powdered form thus making our shipping costs so much cheaper and easier to distribute , BUT we can sell/rent those rights to whoever wants to pay us ?.

If we don't get an rto we will all be down 100%

Has it got anything to do with a product involved in producing Traumakine that other pharmas cant use without our permission.

So probably not so much that it is concentrated, but as it is patented nobody else can use it or transport it in the same way as we can which basically gives us the global rights to it.

Traumakine is held in a concentrated form prior to being mixed with saline water before being administered so it could be in the way it is concentrated and distributed ?

Has anybody else noticed how gdr and avct seem to be tracking each other% wise both up and down

Spoilsport, we all know everything is Zen s fault especially if it rains , snows or anything else ha ha .

Its late so I may be well off ifn-b1a is used for other ailments so do we have the patent rights for lung treatments,ARDS

And it seems that we are making a bit of noise in the remap study as we get a mention in the papers below along with anakinra