Member Info for Bella6532

Pilgrim 1 - re the link you just posted (dated 19 March 2020) https://news.sky.com/story/coronavirus-new-treatment-for-critically-ill-patients-to-begin-as-soon-as-next-week-11959914

I find these statement interesting:
'Doctors have high hopes that it could also help stop the coronavirus in its tracks.'...
'Scientists believe it will prevent the coronavirus from taking over lung cells to make further copies of itself.'

Is he actually quoting Doctors and Scientists or is it journalistic licence!!!

Now we're being told a vaccine is not realistically going to be available in large enough numbers for at least 18 months...so what to do? What if you just issued everyone with a SNG001 nebuliser...I wonder how quicky could production be ramped up and to what volumes...

Buying time and preventing CV from copying itself in viable hosts MUST be the two most important considerations right now...

Common SNG...

Morning everyone...I do hope you are all managing to keeping safe. Tough times right now. One thing is for sure, we will emerge from all of this with a very different attitude to life and values...
Governments around the World are going to have to kick start economies as soon as possible to generate their own cashflow and the best way for them to do this is pushing forward large construction projects and opening up the contruction sector as a whole which can only be good for the likes of V in steel.
https://www.berwickpartners.co.uk/what-we-think/leadership-insights/kick-starting-the-economy-through-construction-and-infrastructure-12696/
This is a very interesting IRENA article...
'governments are embarking on the monumental task of devising stimulus and recovery packages. These are at a scale to shape societies and economies for years to come.'...
'Many renewable technologies can be ramped up relatively quickly, helping to revive industries and create new jobs.'...
'The latest oil price developments and the heightened unpredictability of returns on hydrocarbon investments make the business case for renewables even stronger. Current market dynamics could further weaken the viability of unconventional oil and gas resources and long-term contracts. The moment has come to reduce or redirect fossil-fuel subsidies towards clean energy without added social disruption.'...
https://www.irena.org/newsroom/pressreleases/2020/Apr/Staying-on-Course-Renewable-Energy-in-the-time-of-COVID19

And now many of you have a bit of spare time on your hands, this IRENA's 2020 Global Renewals Outlook:Energy Transformation 2050
https://www.irena.org/-/media/Files/IRENA/Agency/Publication/2020/Apr/IRENA_GRO_Summary_2020.pdf

All the best to you all, your families, friends and work colleagues...and a huge cheer to everyone out there on the front lines...xx

https://twitter.com/madinitrade/status/1253183037552168960?s=21

EdcJ.. That's the whole point... No chance. In the scientific world their point of readiness is far from when it will actually be scaled up by manufacturers and then you've got distribution etc etc...

Scientists have said one could be ready by Sept but now admit their point of readiness is not the same as commercially ready in volumes needed. With the race to be the first with breaking news the press are a fault on many occasions with misinformation too...

From FT
'Initial delays getting functioning diagnostic tests in the US and persistent shortages of supplies such as reagents and cotton swabs elsewhere have hampered global testing efforts. Now, the prospect of exiting the lockdowns is making tests more crucial than ever in the absence of a vaccine — at least 18 months away — or effective treatments: only wide testing would help prevent a revival of the outbreak, by quickly identifying and isolating new patients, while allowing a return to some normalcy for the rest of the population.'

Countries around the World are looking to ease their lockdown and this means they are going to substantially have to increase their testing and tracing?
Chanel 4 this evening... Leading scientists came to same conclusions..
Jeez this is going to be enormous for Primerdesign. Licencing deals must be only way to scale up production at rates needed... Watch this space...

France 24 this morning reported US governors asked to test more and US looking to buy test kits from overseas sources...
Got to be good for Primerdesign

https://arstechnica-com.cdn.ampproject.org/v/s/arstechnica.com/science/2020/04/cdcs-failed-coronavirus-tests-were-tainted-with-coronavirus-feds-confirm/

Should have called in Primerdesign from the getgo...

I suspect they will go for contract manufacturing first and then a big pharma may licence in the IP...

https://www.bloomberg.com/opinion/articles/2020-04-17/chan-zuckerberg-biohub-is-ready-for-coronavirus-tests-to-come

One of the biggest problems has been a shortage of nasal swabs...
https://www.statnews.com/2020/04/16/fda-changes-coronavirus-testing-swabs/

'Professor Tom Wilkinson, leading international lung disease specialist and Chief Investigator for the SG015 study, commented: "Respiratory virus infections, such as the common cold and flu, are a major cause of exacerbations of COPD, which are the second most common cause of unplanned hospital admission in England, so there is a real need for a treatment that helps patients when they have a cold or flu infection. The biomarker data from Part 1 indicate that we are 'switching on' antiviral defences in the lungs which we hope will translate into a clinical benefit in Part 2 of the study, when patients take either placebo or inhaled IFN-beta for 14 days when they have a confirmed respiratory viral infection. The trial is progressing well, and we are on track to complete the study during this coming winter virus season."'

He clearly refers to the need for a treatment...switching on the anti viral response is a treatment...

This is from the trial doc..
'We will test SNG001 to find out if it can boost
anti-viral responses and minimise the worsening of COPD symptoms/lung function.'

Why would you want to boost the anti-viral response in patients with a runaway immune response??

I thought Interferon was an immune response booster as CV gets into the system under disguise of a cell and so the immune system doesn't see it coming.. When it does realise something is wrong the immune system then goes into overdrive to fight the pneumonia inflammation etc...

Interferon given early activates the immune system....

If it's not a whiff of Eskom, the the only other thing that could be moving us right now IMO is the Enerox purchase.
The Consortium should have made their last payment early Feb and we are now early April - 2 months for due diligence surely has to be enough time...

'The Consortium has committed to make three further staged payments of €300,000 in December, January and early February which will bring the total initial investment in Enerox to €1.65 million. In due course Bushveld Minerals intends that Bushveld Energy Limited, an 84 per cent owned subsidiary of Bushveld Minerals, will take its place in the Consortium.

As previously announced, the Consortium has been granted exclusivity until the end of February 2020 to complete due diligence and now expects to negotiate a subsequent main sale and purchase agreement to acquire the remaining issued share capital of Enerox for a further consideration of €10.85 million on a debt free basis within the same timeframe. Whilst it remains a minority shareholder in Enerox, in addition to the call and put arrangements previously announced, Bushveld Minerals has been granted customary minority protections under the ISPA.'

Now 15.20....
3 April we opened at 8.90 and have climbed nicely since....

I posted this on 8 April....
'Is there another weapon in the coronavirus fight? A Toronto researcher wants to ‘shout it from the rooftops’ | https://www.thestar.com/news/canada/2020/01/31/is-there-another-weapon-in-the-coronavirus-fight-a-toronto-researcher-wants-to-shout-it-from-the-rooftops.html
INTERFERON!....INTERFERON!....INTERFERON!

1. If SNG didn't believe rgey were onto a winner why on earth raise £14m.
2. If those participating in said over subscribed fundraiser weren't confident SNG was onto a winner then why did the buy into said Fundraiser and how many went Inside.
3. 11:00 tomorrow is the vote.
4. SNG know their stuff and would not be taking this through hospital patient trials if they weren't pretty confident in having a winner.

MEM... Totally agree. Spent many years working with agents in the ME and travelling there. Saudi used to call the shots as I'm sure you know especially on the issue of maintaining their 'dry' status... lol!! And as you say what Saudi does the rest of the Emirates et al tend to follow.. Except of course the likes of Iran. But even they may be looking to get their hands on some highly reliable testing kits too...

Pumky... It's a fact of life someone will be holding when an SP drops but no need to rub it in as it just sounds like sour grapes... Are you actually invested here or just upset you think you missed out...its not another PXS.

Will we see a production licencing deal with AZ and/or GSK next?

https://www-bloomberg-com.cdn.ampproject.org/v/s/www.bloomberg.com/amp/news/articles/2020-04-08/novacyt-2020-gains-hit-1-600-as-who-makes-virus-test-available?amp_js_v=a3&_gsa=1&usqp=mq331AQFKAGwASA%3D#referrer=https%3A%2F%2Fwww.google.com&_tf=From%20%251%24s&share=https%3A%2F%2Fwww.bloomberg.com%2Fnews%2Farticles%2F2020-04-08%2Fnovacyt-2020-gains-hit-1-600-as-who-makes-virus-test-available