RE: Avacta website pipeline19 Jan 2024 13:28
CytoImmune’s lead product: CYTO-102 (CI-NK) cell therapy, aims to enter the clinic in combination with atezolizumab (anti-PD-L1 monoclonal antibody) for non-small cell lung cancer in 2022.
Avacta: ‘A number of potential ImmunoCytokines are under development."
Avacta: AVA028 / 032 – PD-L1 Affimer® / ImmunoCytokines
The flexibility of Affimer technology allows multiple formatting configurations to generate multispecific molecules. These molecules utilise the tumour cell homing functionality of the PD-L1 inhibitory Affimer to bring immunomodulatory cytokines directly to the tumour and reverse the immunosuppressive tumour microenvironment by enhancing T cell activation but avoiding T cell exhaustion. A number of potential ImmunoCytokines are under development.
And then there’s
Avacta: AVA021 – PD-L1 Affimer® / LAG-3 Affimer®
AVA021 is an Affimer® bispecific including Affimer® inhibitors of both the PD-L1 and LAG-3 mediated checkpoint pathways. The molecule is designed to prevent PD-L1-mediated inactivation of an antitumor immune response, revive exhausted T cells through reversal of LAG-3 signalling and by virtue of the targets of the bispecific being on two separate cells in the tumour microenvironment, activate T cells to engage and kill PD-L1 positive tumour cells and tumour-supporting stromal cells.
Despite advances with therapies targeting the PD-1/PD-L1 pathway, many patients are refractory to or relapse following treatment. Resistance to anti-PD-(L)1 treatment in these patients is often associated with upregulation of other checkpoint pathways, particularly checkpoint pathways which cause T cell exhaustion and inactivation in the tumour such as the LAG-3 checkpoint. It has been observed that antibodies that bind to LAG-3 and inhibit its interaction with MHC II are capable of reinvigorating exhausted T cells. Avacta’s LAG-3 inhibitory Affimer® binds to LAG-3 and inhibits the binding of MHC II, reversing the mechanism by which it produces the T cell exhaustion and reactivating these tumour-fighting T cells.
AVA021 is a bispecific Affimer® designed to produce dual checkpoint blockade of these two pathways.
It looks like Christine liked what she saw at Avacta and the way their work with Affimers is taking them…
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