Member Info for B2HS2L

Looking at the trading in the last couple of days, I don't think there are any leaks concerning loan negotiations.
If there were, larger chunks of shares would be being purchased.
People are buying smaller chunks and acquiring a lot of shares for peanuts.
The risk reward in present circumstances is high, but the prize is very attractive.
IMO TRX is on the list of many new investors, and believe new Chairman Jonathan Glenn together with Gareth Jones have got what it takes to get a new loan.
Jonathan knows all that is necessary to know about TRX finances, its operations, and its partners.

TRX has some valuable patents, and even if the company is divided up and sold we are grossly undervalued, and IMO selling the whole company off will not generate as much as selling the component parts off.
A new deal is not a certainty, but these guys should be able to pull it off.
If they can't nobody can.

Hi Tom,
https://www.basingstokegazette.co.uk/news/regional/andover/18354750.basingstokes-super-fast-covid-test-set-rolled-across-uk/

“We were in a fortunate position to be able to link with a local company in Chandlers Ford, PrimerDesign, who partnered with us to provide the testing kits needed and we are very delighted that we could join forces to make this a reality so quickly.”

This test is the LAMP technology test to detect if you have the virus, not 'have you had it'.

I wish then every success with their efforts, for all our sake as well as the company.
I don't want Novacyt to spend too much without significant chances of success.
Joining forces on a combined project might be difficult to arrange, but this is what it might take to get success.
Matt Hanc*ck should be realising soon, that this is what it might take.

https://www.theguardian.com/world/2020/apr/05/coronavirus-testing-kits-could-be-unreliable-uk-scientists-say

"Emerging evidence suggests that there is a wide range of antibody responses to coronavirus across the population, which may make the development of a simple, reliable home test that will work for everyone a considerable challenge."

Good overview of the present situation presented here.

I think it is going to be much harder for anyone to produce a successful Antibody test than previously thought.

If Novacyt are involved in an Antibody test, and success is elusive, lets hope the company knows when to quit.

From the RNS:
"In addition to the test currently being approved in the UK, the US, France, India, the Philippines, Argentina and Thailand, it is available in markets which directly accept CE-Mark accreditation without the need for further approval."

This includes much of the Middle East.

Perhaps try plugging the financial terms you don't know into Investopedia.
You can find a lot more besides there.

Nice find skittish, - memorable.

Speed of cycle processing and maximum number of tests per cycle is becoming more important, as efforts increase
to process test results faster.

Primerdesign's test kits (96 tests per kit) are compatible with the following instruments:
In order to maximise test kit sales, we need to ensure all are aware of the below compatibility for our tests.
I have placed the maximum number of tests that can be processed per cycle against each instrument

Applied Biosystems®7500 Real-Time PCR system 96 tests.

Bio-Rad CFX Connect™Real-Time PCR Detection System 96 test.

Roche® LightCycler 480 II 96 tests or 384 tests.

Bruker-Hain Diagnostics' GenoXtract® automated nucleic acid extraction device 12 tests.

*Note: Bruker and Primerdesign are working together to validate Primerdesign tests for use on Bruker's new instument:

FluoroCycler XT PCR instrument 96 tests.

Graham Mullis stated in an early interview (6 weeks ago) that the cycle times for the Primerdesign q32 instrument
were less than 2 hours, and that a team was working to reduce this time further.

Now the 32 is being advertised as per below link as "Fast DNA and RNA analysis in less than 60 minutes"
http://www.primerdesign.co.uk/products/10019-genesig-q32-real-time-pcr-instrument

I hope to receive a response on Monday from support to verify time to process 32 results is now less than 1 hour.

If true we should sell more instruments.

Re need for a big RNS:
Look at the list below of reasons why sp might be affected, -
how many might land together to contribute toward that 'big RNS'?

Manufacturing outsourcing update
US sales figures
Further FDA approvals
Further OEM / NHS sales update
News of next UK test kit manufacturing partner
News of a Takeover
News of a Joint Venture
News of an NCYT Antibodies test kit, and distribution of same.
CFDA Approval

IMO a 'big RNS' is unlikely, except for a good sales figures RNS.

5eight, - Just used the link, and found the price of a Genesig Q32 Real-Time PCR Instrument to be $20,060.00,
(£13,000 in UK). Test prices a lot higher than equivalent UK prices.

It also states Q32 Product features:

Fast DNA and RNA analysis in LESS THAN 60 MINUTES.

I haven't seen 60 minutes quoted on the Primerdesign website before.

Will be contacting support to verify.

If true, and giving time to reload, I recon 320 tests could be performed in 12 hours, so it is not as slow
as implied in other documentation.

johnnybbad,
There's a couple of aircraft carriers that would make floating C19 recovery vessels.

HMS Nightingale 1 and 2.

https://www.basingstokegazette.co.uk/news/18343185.basingstoke-hospital-reduces-testing-time-covid-19-five-minutes/?ref=ar

Another article on the same team dated a couple of days earlier.

Doctors are acting on the results of the tests the team are producing??

Veronica said Hampshire Hospitals NHS Foundation Trust is leading the way in testing, adding: “The doctors are coming down regularly to get the results of priority patients and they all said it’s a game changer for the NHS. If we complement their tests with this rapid test they can go back to the ward and the patient can receive the treatment they need probably a good half a day earlier.

“I was confident it was going to work but to see the delight on people’s faces, it’s giving the NHS another tool. The situation is horrifying so we need as much help as possible and this is a tool to help.”

https://www.basingstokegazette.co.uk/news/regional/andover/18354750.basingstokes-super-fast-covid-test-set-rolled-across-uk/

"This assay is not dependent on the same reagents as the other front line tests and therefore is much less susceptible to reagent shortages which is a major concern for the front line tests currently in use."

Also:

“We were in a fortunate position to be able to link with a local company in Chandlers Ford, PrimerDesign, who partnered with us to provide the testing kits needed and we are very delighted that we could join forces to make this a reality so quickly.”

From the above I think although Primerdesign provided the testing kits, they did not contain "the same reagents as the other front line tests".

News of a successful Novacyt Antibody test should land first..

Those in charge of the wards PPE should be sacked for wasting public time and money if that happened.

Rather get a shot of them getting the bum's rush out the tradesmans entrance!

Great Post johnnybbad, - can see a knighthood for the team members if this is validated to PHE satisfaction.
The ROW will all want the process. Sounds like this could be used anywhere with a power supply.

SAMBA II instrument has the capability to deliver 72 test results per day.
Inadequate capacity for Matt Hanc*cks needs.
It makes more sense to distribute Primerdesign q32 instruments, and get 32 test results in 2 hours.

The achilles heal of the Primerdesign offering is the instruments which the company sells
with which to process the best in class tests.

The largest (the q32) can process 32 tests in less than 2 hours.

Our test kits (96 tests per kit) are compatible with the following instruments,
against which I have placed the number of tests that can be processed together (max capacity):

Applied Biosystems®7500 Real-Time PCR system 96 tests.

Bio-Rad CFX Connect™Real-Time PCR Detection System 96 test.

Roche® LightCycler 480 II 96 tests or 384 tests.

Bruker-Hain Diagnostics' GenoXtract® automated nucleic acid extraction device 12 tests.

Here is the flyer for the Bruker-Hain instrument:

https://www.hain-lifescience.de/uploadfiles/file/produkte/geraete/GenoXtract/genoxtract_eng.pdf

Yesterday I contacted the company and asked:

Do I have to wait longer than 2 hours for a result from the 3 compatible instruments?
( I did not mention the Bruker instrument)
Ans = The ABI, Bio-Rad and Roche machines take 2-3 hours to run the tests.

So I believe that there has been a lot of purchases of our kits,
for use with the above equipment and not for the q32, for processing in bulk.

IMO the Govt have so far been sidelining the Primerdesign offering because in 2 hours you only get 32
high quality test results, whereas you could process 96 or more tests on compatible instruments in 2-3 hours.

If there is going to be large scale changes in order to get processing of tests up to 100,000 tests per day by the end of April,
(quoting Matt Ha**** tonight), the company needs to be advising that processing on compatible equipment,
in order to get the highest quality test results.

Recall CMO Chris Witty saying "A bad test is worse than no test."?

The best test is a Primerdesign test not the shoddy tests (in comparison) made by the above manufacturers.

@ Ghia- posted 17.03.2020

https://twitter.com/trade_Fabrice/status/1239877092084457472

17.03.2020 - Jacob Barratt qPCR - Primerdesign Ltd

"I'm happy to announce that after a huge effort from the UK Primerdesign team PHE have trialled our Covid-19 qPCR detection kit (CE-IVD marked) which performed perfectly.
PHE have placed an initial order for 1,200 kits (thats over 115,000 individual tests) for use in 8 of their major testing hubs throughout the UK."

115200 / 1200 = 96 tests per test kit, ((COVID-19) genesig® Real-Time PCR assay Instructions for use, confirms 96 tests per kit) https://www.genesig.com/assets/files/Path_Coronavirus_COVID_19_CE_IVD_IFU_Issue_10.pdf?timestamp=1582079599

1200 kits = £1,000,000 order = £833.33 for each test kit.
£833.33 / 96 = £8.68 per test

If Primerdesign can get a large share of the Indian market (anything over 25%), then everything else that was sold to other countries, including the UK , would be a bonus.

If it can be combined with an antibodies test, it would make the decision to purchase both a no brainer.

It would do wonders in supporting the sp.

I haven't seen this link on this board recently.

https://www.biopanda.co.uk/php/products/rapid/infectious_diseases/covid19.php

It is from BioPanda reagents, and shows when the antibody test becomes usable to detect antibodies, indicating the patient has had the virus.
https://www.biopanda.co.uk/php/products/rapid/infectious_diseases/covid19.php

Interestingly, according to the DM today, the BioPanda website says they are unable to accept orders from outside UK at present, and the govnt is known to be interested in using this product.

Associated DM link:

https://www.dailymail.co.uk/news/article-8177189/UK-bought-2million-coronavirus-antibody-tests-China.html