Member Info for ajithoth

Could you ping me the link please Thoth? ajithoth at gmail dot com cheers

hello - my username on here at g mail dot com thanks

http://investor.sierraoncology.com/2018-03-14-Late-Breaking-Abstract-Reporting-SRA737-Preclinical-Activity-in-CCNE1-Driven-and-PARPi-Resistant-Cancers-Accepted-for-AACR-2018-Annual-Meeting Poster will be available on Tuesday

In CCNE1amp tumors, SRA737 showed profound activity as a monotherapy in this PARPi-resistant model. SRA737 is a new potent and selective Chk1 inhibitor that demonstrated activity in acquired PARPi-resistant as well as CCNE1amp preclinical cancer models, warranting further development in these HGSOC subgroups. This is excellent news. so for that 1 in 5 ovarian cancers that end up coming back and build up resistance to platinum based chemo a new novel drug, CHK1 may be the new last line of defence. This could save a lot of lives globally.

28p for me. The magic number.

this p1 trial is at the Christie but it states that chk1 is delivered in capsule form not iv. However some points of the MEN article may have been deliberately obfuscated. http://www.cancerresearchuk.org/about-cancer/find-a-clinical-trial/a-trial-of-sra737-for-advanced-cancer#undefined It'll be interesting times if we start to get success stories filtering through.

It kind of does, looking at the timelines and the profile of the drugs being tested, however I'm not sure if the Christie was part of phase one trials. I'd be glad to hear other peoples opinions. https://www.manchestereveningnews.co.uk/news/health/mark-steel-cancer-christie-trial-14474202

the silver lining with letting sierra develop CHK1 and push it through trails is that we are not facing dilution like Sierra probably is now. On one hand its annoying that we haven't broken 1p but on the other hand we haven't tanked to 0.5-0.6p regions which lets face it, many AIM shares half in value overnight. Lets see how this develops over the next month or so.

well after a mistimed buy on VAL I'd much rather SAR hit 20P first, I would be far more in profit ! I think the YA thing could drag on for a bit but news on 201/401 could drop anytime. But back to SAR, hopefully we will see some fireworks with SAR in the next week...

I certainly hope so. Are you still in VAL Herbie?

its a shame you don't get one free share for every 4 you buy at AZ everywhere else isn't it?

Yet more positive newsflow from Sareum - they seem to be on a good run. Long may it continue.

Well lets enjoy the peace and optimistic outlook of the BB while it lasts. In a couple of weeks the stampede will arrive and it'll all be buy sell buy again, will it, wont it, oh yes it will oh no it wont. Got to admit I'm looking forward to it though. Will anybody admit to that rather large purchase at 4pm then?

well with any luck a payment of 4.4M might give us a new baseline of 1.2P. Would love a 15M one though to take us up to the dizzy heights of 1.6 - 1.8P

GSK already has a foothold in HIV/infectious disease and respiratory, but wants to grow its oncology and immune-inflammation units. well we tick those boxes.....