Member Info for ajithoth

I wonder if somebody has been fiddling with pagerank\rankbrain as SAREUM is 1st or 2nd result now when you google "TYK2 Covid"

I'd need more than a bit of luck with Pulev, he's a scary looking dude! Hopefully I'd be able to outrun him.

https://www.ukri.org/news/five-genes-identified-that-could-be-key-to-new-covid-19-treatments/

https://www.ed.ac.uk/igmm/news-and-events/news-2020/genes-could-be-key-to-new-covid-19-treatments

this will be everywhere in a few days. We need Sareum listed on the news articles.

fantastic. hitting mainstream media.
Wouldn't want to be out of this over the weekend - oh I forgot, I'm not.
Hopefully this is the start of a cracking rise that makes the recent 3p look like a blip.

https://www.theguardian.com/world/2020/nov/22/why-the-race-to-find-covid-19-vaccines-is-far-from-over

Good that you got in touch then Num4.
It does go to show that SAR are actively doing things behind the scenes.

top counter tweet Num4 !

bit of a kick in the knackers but hopefully this means CHK1 is pushed quickly now. At least we get past this impasse and after a short term drop it'll tick up again. We could really do with some another positive RNS from SAR to drive the SP up. Certainly better then the who blinks stalemate of the last 2 years. Even just half a mill will push back any immediate need for a raise. so no speeding tickets. no raise. CHK1 progressing, possibly even accelerated. Short term pain but good long term.

yes of course, vaccine 1) not peer reviewed 2) not large enough volume of participants have caught covid yet so not statistically significant 3) logistically difficult as needs to be -80 or whatever, needs special fridges - you can't just turn up your zanussi 4) may be of limited use due to fading over time 5) will take a while to scale up production but of course can be outsourced. 5) not all people will have it.
Plenty of space for vaccine, treatments and testing. We are in a 'vaccine bubble' at the moment......this isn't going away anytime soon and it's going to get worse before it gets better.

no, in Interactive Investor account. waited until 5pm as price always wrong until then.
same, 1.5, on ADVFN.
Some chat over there today as peeps on here missing LSE board.

SAR finished at 1.5 today. manipulated all day. artificially suppressed to shake out the weak.
the price on here is incorrect.

yay back up again.
Soldiers just purely for logistics and distribution.
I was looking at those fridges last night, £20k for a 12L one.
I bet there's a waiting list with Thermo now for them.....

Hi Covno - it all seems to relate to vaccines. It'll be interesting to see if our mystery partner for FLT3 is Sinovac or Sinopharm and if they are using FLT3 as a vaccine adjuvant.

Hi Blastoid - yes, I'm quite excited, I've tweeted Robin who wrote the article bringing Sareum to his attention and that we have got a UK Gov Grant and its more selective than Baricitinib. With a bit of luck the article might be updated. I'm hoping that we will get some cover in other papers or from the BBC very soon. As soon as we get more coverage there could be a stampede.

everybody will want a piece of the cake soon......
https://www.theguardian.com/science/2020/nov/01/covids-effect-on-health-blamed-on-tiny-genetic-variations

£1.5M. Look at what is being awarded, there are many more grants for over £1M compared to the ones under. Many are just bits of research. We have a drug, on the shelf, ready to go.

Hi Jon - I meant to then forgot - noticed it was 50% up yesterday and kicked myself!

https://www.theguardian.com/science/2018/feb/21/the-drugs-do-work-antidepressants-are-effective-study-shows
Look at this article from the Guardian that talks about antidepressant efficacy.
You can see that many are not much better than placebo. Many not well tolerated, yet this is a billion $ market.
I hope that this puts this mornings results into perspective, these are great results. Now into PIII
This is a positive outcome for many sufferers and has a very good safety profile, big P's eyes will be all over this.

I got some ncsi at recent high, will average down when dddd comes good. All a bit of a sideshow while waiting for sareum...

complex bang up to date cancer immunotherapy paper from China.
Myeloid-derived suppressor cells (MDSCs) activated in body under adverse conditions.
Identification of these are controversial as difficult to differentiate between other types of while blood cells.
Support tumour growth so the paper investigates different methods of tamping down the effects of these cells.
The combination of of targeting MDSC's and other therapeutic approaches demonstrates powerful anti tumour effects
MDSC's normally immature cells that don't cause any issues. However under adverse conditions, such as autoimmune disease, infection and cancers, MDSCs are abnormally generated and activated.
Tumour treatment strategies targeting MDSCs are highly valued.
in depth analysis of different ways of suppressing these cells. Talks about targeted combinations of therapy.
3.2.2 SRA737 and anti-PD-L1 and low dose chemo specific types of anticancer cells (T cells, dendritic cells and type of white blood cells) significantly increased. MDSC's decreased.
This is one of a number of different ways to get the same outcome (reduction of cancer, increased survival rates) detailed in the paper.
Doesn't really say which is optimal. But ends with the statement that monotherapy (just using one type of drug) isn't good and dual or triple therapy will become the way that cancer is treated in the future, which is exactly what the PD-L1\SRA737\chemo therapy is.