Member Info for ajithoth

yes it's very much "a nod and a wink" from Sareum....I'm very optimistic for this week.

this is the correct URL
https://www.express-journal.com/non-receptor-tyrosine-protein-kinase-tyk2-market-7234/amp

You need to post more fearg, you are smashing it with 9 recommends....

indeed Stoney - Let's face it a vaccine might be a while off, might not be possible and almost certainly will not involve us. We can help with ARDs though, and if the world had a treatment to treat those most badly affected everybody could lift social isolation and get back to work.
We could treat those few percent worst affected in hospital and hopefully have a very high remission rate.
From what I read about remdesivir it's hard to scale up production, so even if it is a success it'll have limited production and I bet orange head wont let much out of the US either.
Would love to know about mass formulation of Tyk2 and what time scales would be involved to get a million doses created.

great news - I've bought some nicotine patches but every morning I look at them then light one up and think "I'll put one on tomorrow..."

quite possibly to control sepsis and other related comorbidities

sea of blue buys, I like it.
interesting to note that AZ are trialling Calquence which is a BTK inhibitor another member of the tyrosine kinase family.
I think we are on the money here.

Just out today... Tyk2 is one of the JAKs.. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30628-0/fulltext

Personally I'm positive, its just a sh^t show out there today across the board.
there are so many more entries in the "share fallers" today compared to the "share risers"
Terrible to see the values so far down, like others I cant really afford to lose on SAR like I have with VAL, and PYC isn't doing too good either but hopefully we will get above 1p soon.

Hi Fadec - have a read of this, unless I'm mistaken I think this is the implied combo therapy:
https://www.astrazeneca.com/our-therapy-areas/oncology/dna-damage-response.html
so think Wee1 , this has been mentioned before by Thoth a while back

then they did the same with Alderley Park after investing 100's of millions on the site.......

ah ok - I guess you worked at Astra site Charnwood then before it shut down.

Hi cfhmetal - I agree its frustrating at times, especially the drop over the last 18 months.
Surely something must have attracted you to begin with.
Did you work on the pharmaceutical or agrochemical sides of those companies?
I am hopeful that this is our year for Sareum, hopefully the "significant shareholder value" statement comes true in 2020.

if tyk2 mediates cytokine storm that leads to sepsis, could be used as breakthrough treatment for coronavirus

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30305-6/fulltext

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378830/

But might be putting 2 and 2 together to get 5...

I'm half wondering if srra are just watching and waiting for other pharmas failure to strengthen their poker game......

Hi RP - I think its this one
https://clinicaltrials.gov/ct2/show/NCT02928224
not related to SAR

Let's hope we get the application approved. Better than best in class now. Great detective work Fadec!

wouldn't that be good Ahfam, it'd be proper brown trouser time but very welcome.

spreads a bit rubbish but good to see the ask at 0.45p

me too - don't know if thats good or bad.