Member Info for ajithoth

water on the moon!

https://seekingalpha.com/news/3384750-sierra-oncology-halted-pending-news

ah yes I see.
Well hopefully it will work on them, because they typically have a very poor outcome and this will prove the efficacy of SRA737.

SRA141 isnt our drug though, or am I missing something?

They sound like pretty horrible diseases. I knew about ALS, because that's what S Hawkins had but not about DMD. Let's hope sar can turn some of the suffering around and improve the lives of those afflicted. https://en.m.wikipedia.org/wiki/Duchenne_muscular_dystrophy

from a personal point of view It'll be interesting how well TYK2 works as a biologic for Ankylosing Spondylitis.
Humira is the one to beat, its also the biggest grossing drug in the world.

I can't see Searle's post on my mobile but I can on my desktop.
I couldn't see Thoth's post in the early hours but could see Afnam's but now I can see both on both systems.

theres also development of VEGFR-3 to consider. Its been forgotten about but preclinical molecules are probably being developed.

Mr Orange will be back...... (is he like the Candyman where we have to call his name 5 times?)

Great to have a goodnight story from you Thoth that gives a warm fuzzy feeling. Roll on next week.

https://www.astrazeneca.com/what-science-can-do/ddr.html this mentions aurora and the possibility of combining DDR with each other. Aurora & Wee1 & PARP combo?

fantastic analysis. recommended.

stop talking shit Dave - it is good news if its developed and pushed out to market as a viable drug.

I don't think this will impact the share price in the short term but its good to bring it back in house so it can be given the attention it needs. Some of the data may need to be analysed for integrity as some Chinese Data Trail Results have been known to be falsified. Its another (almost) wholly owned molecule that makes us an even more viable buyout opportunity.

New link between mononucleosis (EBV) and ME\CFS https://www.prohealth.com/library/groundbreaking-ebv-finding-help-explain-cfs-80544 Can TYK2 help with this? It certainly looks like it can block some of the transcription factors epstein-barr virus inserts into the cells. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851581/ the market for CFS\ME is (probably) astronomical.

Don't forget Dave it usually drops like a stone just before good news. Now I'm not saying that's going to happen in the next week or 2 but be prepared and see it for what it is when it happens. I've thrown the kitchen sink at this but believe it'll all come good in the end. Going back to the 737, biggest selling aeroplane of all time. The numbers shipped were huge and very profitable. Lets hope our 737 is the oncology equivalent......

This is why we need scientists like you Hopkirk !

It was the figure of '150' recruits that caught my eye, same figure as sra737 in the Clinical trials Web page. Also occurred to me that 737 is the same number as a jumbo jet..... I think they may have picked that number purposely.

the beeb also has this article. Poor woman. http://www.bbc.co.uk/news/uk-44196105 the trial sounds like it might be chk1.

good find ! it looks like TYK2 is almost a medical silver bullet, a panacea for all ills. fingers crossed, g