Member Info for a-2-b

Even cornering the European part (20%) is nothing to be snuffed at considering the mcap is so low lol

http://www.cityam.com/286088/city-analysts-say-theres-more-ma-activity-horizon

http://www.epo.org/learning-events/european-inventor/finalists/2017/muller.html (Read Economic Benefits and The Inventor section) If anyone would know it's these considering she filed a majority of her patents there

I've been looking can't find much my guess is they have to be very careful what they say and what is released due to the non-disclosure agreements in place with multiple companies. Today been doing a lot of research into Sylviane Muller she is a multi-award winner for this research/drug discovery to say the least there is nothing out there quite like it. I'm pretty confident this will get to market or bought up by a large company it's too good to overlook to be honest. The benefits are undeniable in many contexts.

Can't rush excellence. I'm quite interested in the other peptides they have to offer the whole thing is pretty revolutionary non-immunosuppressive/non-opiod treatments are greatly needed in the world.

Just have patience this is bound to come good in the end. Take bpc for example did **** all for 8 or more years about 2 weeks ago 200% rise and destined to go much higher on the right news. I got in there a few months ago luckily after doing research on it. Out of experience it's the quiet ones you wanna watch out for. This will prove to be a shocker once it gets on the move. I don't have anything against Zorbas or Hogan people have slated them on here for awhile but they have not been selling their stock like most will speculate.

Since the large sells yesterday the sp seems way more responsive off small trades

I thought it was a buy but makes more sense it being a sell. That very well could of been the last of aviva if not they literally have nothing left now. From the last lot of large block sells I estimated about 400-600k shares left but no accuracy in that though. Hopefully we get notified soon.

Guess we could receive an update regarding it soon, although it might be pretty hush now with all the pharma talks going on, even the speakers at autoimmunity will have to be pretty tight lipped too. This is definitely going to market way better than steroids any day of the week.

If the extension is almost finished as I believe the trial was finished in January.

Here's a drug which has failed to reach statistical significance at endpoint within 2 phase 3 trials, yet it is very good and being pushed through to the FDA sometime next year: https://www.healio.com/family-medicine/pain-management/news/online/%7B99c3e1d2-624a-43c9-b06d-a4e803258532%7D/alder-allergan-report-success-in-developing-migraine-treatments Also evaluated by Albert Einstein College of Medicine

If you look through thursday @ https://autoimmunity.kenes.com/2018/Pages/Interactive-programm.aspx#.Wvy1Jogvy00 you can see tyhe whole breakdown of the program tomorrow: PL07 PARALLEL SESSION LUPUS: WHAT IS NEW? 17-May-2018 10:30 12:30 Abstract: THE P140 PEPTIDE, A HEAT SHOCK PROTEIN INHIBITOR, MODULATES LYSOSOMAL PATHWAYS FOR LUPUS THERAPY Background P140/LupuzorTM is a phosphopeptide exhibiting significant protective properties in MRL/lpr lupus-prone mice and patients with SLE. It is currently under evaluation in phase III-clinical trials in the US and Europe. Method Various biochemical methods to examine the interaction between P140 and HSPA8 in vitro and in vivo were used. Results One of our key findings regarding the P140 mode of action is that in vitro P140 binds and inhibits heat shock proteins HSPA8/HSC70, a chaperone protein that plays important roles in various cellular functions. We show that it decreases HSPA8 expression on gene and protein levels, both in vivo in MRL/lpr mice that received the peptide intravenously, and in vitro, in MRL/N-1 cells, a fibroblast cell line derived from the MRL splenocytes. We discovered also that P140 significantly affects the capacity of HSPA8 to shuttle between cytosol and nucleus upon heat shock. Another important cellular function of HSPA8 is its role in chaperone-mediated autophagy (CMA), a selective autophagic pathway also mediated by chaperones HSP90AA1 and lysosomal receptor LAMP2A. By purifying lysosomes (where P140 accumulates) from the liver and spleen of MRL/lpr mice pre-treated or not with P140, and incubating these lysosomes with CMA substrates, we observed a decrease of intra-lysosome uptake of CMA substrates, confirming in vivo the inhibition effect of P140 on CMA. Conclusion The inhibition effect of P140 on HSPA8 is not only important for lupus therapy where HSPA8 has been reported to be overexpressed, but potentially also in other autoinflammatory diseases, including neurological diseases, where modulation of HSPA8 is needed. Co-authors F. Wang 1, I. Tasset 2, A.M. Cuervo 2, S. Muller 1 1CNRS- Institut de Biologie Mol�culaire et Cellulaire, Immunopathologie et Chimie Th�rapeutique, Strasbourg, France 2Albert Einstein College of Medicine, Department of Developmental and Molecular Biology, New York, USA

Actually I lied the Maria Cuadrado lecture was yesterday but it officially started today. The lupus talk is tomorrow 10.30-12.30.

Only this programme: https://autoimmunity.kenes.com/2018/Documents/Auto%202018%20Preliminary%20Timetable%20-%2010%20April.pdf Seems like the last lecture pre-open and the first topic of opening are relating to here personally.

Maria Cuadrado gave 40min lecture today titled 'Do we need steroids for autoimmune diseases?' I wonder if IMM popped up in her talk.

Well lupus talk is tomorrow morning, not expecting it have a effect on here but I've seen stranger things.

Vol dead today which is nice to see buy and hold

IPP-102199 would be amazing to get people away from opiate based painkillers, something which is badly needed in the world.

Plenty to talk about at the expo think these peptides are very interesting personally as they cause no damage, adverse side effects or weakening to the immune system which is amazing. Think it starts tomorrow and goes on till Sunday. At this rate the shorts will close we're holding extremely well about this level.

I predicted 12p sometime in June, that could very well still happen still plenty of news to pump out. Kinda like how underground they are being about it if I'm honest, I'm in no rush anyways.