Junior-listed AIM shares drop 0.4 percent, laggingthe FTSE Small Cap index, off 0.1 percent, butoutperforming the midcaps, which fall 1 percent.
Tissue Regenix gains more than 15 percent after theregenerative tissue specialist signs distribution agreements inthe United States.
"This should allow a strong entry into the U.S. market withthe company having set up very detailed commercialisation plans(there)," Panmure Gordon says in a note.
The broker lifts its target price on the shares - currentlytrading around 20 pence - to 22 pence from 18 pence.
Richland Resources advances around 20 percent afterits subsidiary Tanzanite One Mining signs a joint ventureagreement with the State Mining Corporation.
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