Ryan Mee, CEO of Fulcrum Metals, reviews FY23 and progress on the Gold Tailings Hub in Canada. Watch the video here.
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Are non-shareholders forbidden from discussing VAL here? How would potential new investors do any research (you do want people to buy shares I would expect).
You could always start a closed group on Twitter or Telegram but that is not the point of this BB.
No he doesn’t. Also he’s underwater with SCLP, which is why he’s spouting nonsense to get people to go over there. Claims to want to discuss, yet ignores any points I make, then comes up with made up scenarios that Suzy has already addressed...as she said in the Q+A that we will progress, not go back. No winning against someone who is blithely making things up, by still talking about it a phase 1 approach, as reason isn’t considered in making things up there.
Also, if anyone listens to the ridiculous statement that ValiRx should have released full results and not headline, then sells on that...they deserve to lose their money, as clearly have no understanding of how pharmas work and report results on AIM.
INANANO- do you hold any shares here ? easy question to answer
Bankfool ..
not here to argue ... but discuss what is in the RNS ....
i am sure those wishing to buy VAL would be very interested in why you and others are trying to stop any discussion ..
I have no Agenda
For God's sake stop it!
Direct your questions to Suzy Inanaco I don't want to read a bun fight on here.
Innaco
Val said these were preliminary results with full results to come when the numbers were churned.
You're trying to make a problem where there isn't one which suggests an agenda.
Grace
How do you explain this statement from the RNS
Nevertheless, the headline results clearly demonstrate that VAL201 has the potential to be a safe and well-tolerated drug. With this data in hand, future studies will investigate optimal dosing strategies for VAL201
what does that mean ........ increase would require a Step up via a """phase 1 approach """
if you change how you dose, timing etc ... that would require specifics to identify which is the best approach
this is exactly what i mean about "deficits"
VAL decided to RNS without the full results ........ and a full explanation ..
so lets say they had "stable decease" ............. for how long ?
Sorry Baxters...I can’t help it and I can’t leave these inaccurate statements on the bb. Inanaco knows they’re untrue, as his scientific knowledge is excellent, but he knows not everyone else’s is.
Right inanaco...
Without looking back at your posting history, didn’t you try to imply that the endpoints haven’t been reached? Therefore phase 1 would have to be repeated. When that was shot down, due to it being ridiculous, you’re now trying to say that a small trial would have to be carried out before the 2b. We both know that’s not true. As your conversation with Adam Pointed out yesterday, it’s largely a non issue, as the 8mg/kg works well. If it were to be further investigated ( maybe there’s no need, as we have possibly reached saturation point for efficacy) then we both know that it could be done simply by adding another cohort to the 2b trial. As you have acknowledged yourself....it works pretty damn well at 8, so great for us.
What’s your agenda? I believe it’s to coax to people sell here and go to SCLP.
Grace, please son’t reply to him.
He clearly need to DYOR.
Grace83 ...
let me explain ... why i point out what i consider "deficits" in the information given out by VAL and look at the efficacy data and what a particular Trial involves
The Original Trial protocols Changed, now if efficacy had been achieved at the lowest dose right up to 8mg that was sufficient to generate the data required to carry 201 into a Major phase 3 trial we would not be having this conversation now. The reason for that, the Phase 3 control Arm will include current standard of care, in other words a Head To Head study, For sure you stand a great chance in the toxicity department to beat standard of care and you could certainly take some market share even if efficacy is lower.
But ..
Val has not completed its dosing schedule to formalize that trial and may consider a further increase in dosage as per the 16mg permission
And that is the issue ........ if the efficacy is good enough why do you still need to run further trials just to sort that out in small numbers before you enter into a full efficacy trial at phase 2 ..
which then asks another question ....
why does VAL not run this small trial and fund with shareholder funds ........ as everybody in the business knows . Data is Valuable .. and at the End of efficacy studies ..... not the beginning, so what is stopping Val running that trial ? This is exactly what the stock market is for ..
not ramp or deramp SP is not relevant
Cb
I buy Britannia’s and sovereigns as they a CGT exempt! second hand and as cheap as possible is the way forward
1 kg silver bars offer a good cheap buy Price per oz but are subject to CGT
Bullion by post is a good site for info, but expensive to buy from ...
Gl
Eyeguy
Before Bown sold/reduced I’d always guessed that 30/40% of Val being held by no more than 20/25 people, so not many left to go round you could say and the longer those people refused to sell the more intense the derampers became and in the end they succeeded in scaring enough to sell through fear of losing any profits so far made.
It’s a one trick pony tactic that should only work the once.
GLA.
Cb
No not a problem, special scheme! Try chards or Atkinsons...
The aim is to purchase the raw metal as cheap as possible :)
Chards is the cheapest I know of, but they are almost always sold out :(
Happy stacking :)
EyeGuy; good insight. As Grace says, the contributions were getting more barrel scraping as time went on. Let's hope there are progressive tie ups announced in due course; I think that would finally empty that barrel! Grace; good insight into the patients from the first phase. I'm also thinking the same re. Initial numbers, and hope that's the case. The further indications also excite me and I hope that some if these alternatives can be explored in the next studies. It may be the case that a couple of preclinical bridging studies in alternative targets would bolster this approach.
OB, sorry to hijack your conversation but what do you buy? Do you buy new, minty or bullion? Any particular dates? I see the new one is out next month. It's a beautiful coin.
Hi Grace
Yep I’m good thank you:) yourself?
I did buy a few more Britannia’s, what about yourself?
Is the pup behaving himself? Oh and hows the new dog ? lol
Sorry you know I cannot behave myself ;)
Rhubarb - I have been doing these boards for years and what you saw yesterday was not a “balanced view.”
Let me elaborate. I suspect darker forces at play yesterday with 100’s of negative posts all trashing the share. Some even set up an LSE account just to trash the company. Are these genuine views? Not at all imo.
They are simply to manipulate the shares down for financial gain.
So these are just fabrication, lies and spin. The RNs could have said the drug worked in 80% of the cases and this still wouldn’t be enough.
Shorts or spread betters needed to finish. No coincidence that I got messages on twitter alleging I had said things which I did not. Again with the goal to discredit with the aim to get people to sell their shares.
Had the same on twitter when the shares were 3.7p. Messages out of the blue, saying I was a conman. Same on here.
The only people worrying about the shares falling were the people that didn’t hold any shares. That speaks volumes imo
Dyor
Some excellent posts here today. Thanks to all contributors. I’m annoyed SP is where it is but hey ho. Hope Val manages to get a JV partner, then all this stress of up and down SP will be forgiven.
I want a retrospectoscope too!
OB, I hope you are well! Any recent silver purchases? :)
Stewart...no offence taken as I’m not in the same league as those two, who have very different strengths :)
There are lots of excellent, measured posters on this bb, who I really admire and are solid.
Great, measured posts this evening, thanks all :)
Lifesagame- thanks! Ten years all clear now, thankfully :)
SG, excellent points as usual. It’s so hard in pharma to figure out exactly what is going on at times. Especially if it’s not someone’s area of expertise. Diurnal got FDA approval today, which will bring in millions in actual revenue imminently, yet they finished lower. Strange week in pharma and on AIM in general. I can see why these types of events would make people look to others, but it is definitely a good rule to stick to, to avoid The opinions of obvious big rampers or derampers.
Adam, thanks, but you are being kind. You summed it up perfectly yesterday when replying that cortisol is the reason the sp dropped. I chuckled for a solid ten minutes. So...are you of the same opinion that the only participants that could have achieved stable disease under PCWG2 are numbers 8, 11 and the four from the extended trial? I can’t wait to see the data. Which means 8mg/kg is effectively currently our MTD...although a cohort with higher dosage can easily be added to the 2b...? (People trying to state that the endpoints haven’t been achieved due to this are really scraping the bottom of the barrel to prey on weakness here everyone. We are certainly not back to square one by any means and why would the next trial take years to complete, just because this one did under the old management...think about it everyone...low tactics employed in that particular attempt. I want it to be known that I have huge respect for that particular poster on his own board, by the way).
Robyems, if you’re reading, then I’m so sorry that you pressed the wrong button and ended up doubling up instead of selling everything. If it’s any consolation, I personally think you’ll be ok. I must admit, I did have a little giggle...maybe it was divine intervention?
I’m happy to discuss the science with anyone and will genuinely give my honest opinion, as if you look back at my posting history, I don’t think this company is perfect by any means and don’t have the same positive opinion on The effocacy of 401 as lots of others (Although I would be more than happy to be proved wrong on this front). But that’s the beauty of everyone having an opinion and being able to debate rationally.
Oh and Nelsonthedog - Adam replied just as I was typing my response that yes, any cancer that is driven by male and female hormones :) I didn’t post as he had already covered it.
Apologies Grace for not praising your input to the forum when I previously thanked Adam and Nick. You guys are helping us no end and putting the works of Val into a clear perspective. We are all fed up with the rampers and derampers and just want to move forward now. Thanks for your expertise
Evening all
Not perfect! but defiantly a calmer bb tonight, and grace is on full form :)
Been a tough few days but things are looking a lot more stable now....
Pebsi use hand sanitizer before u remind others on your concern...thanks I topped up with another 49k@30.5.... Ok
Pebsi , are u stuck on one note all day. Val has frigging confirmed...no placing needed until q4 news is released in December..i believe in our CEO.