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T_P - I now whole heartily agree. Although looking back at past RNS - the full test results will probably just be announced within the next 2 weeks . so much for better communication but we should have realised this since Brooke’s departure.
The science is still there and dates as we know it are still on track. We still have 2 months in the first half of 2024.
Keep the faith, besides little comms…We are still within the expected timescales.
Have a good day all.
TP - good post. Thank you.
The next update from the company has to be 'this is what is happening' and not the usual 'subject to...' waffle we have been provided with for the last two years.
On TFG, I'm not convinced they are actually overly concerned what Synairgen does or does not achieve. Consider TFG's entire portfolio, if Synairgen fails its business as usual for TFG.
Well then Gunto, hopefully TFG now move to dissolve the BoD and get the company auctioned off to BP and some money back to shareholders.
J&J might just pay $400m for full control of a clean Synairgen without the deadweight of Marsden et al.
I am expecting further delays with trials start.
The longer the elapsed time from the last announcement, the more concerning it becomes for LTIs. The most recent periods of long silence from Synairgen have been followed by jam tomorrow statements, which have thus far led to nothing.
We are no longer informed about presentations, or significant staff changes. All we have on this forum is intelligent guesswork based on information from tangentially relevant articles that the best researchers are able to discover.
After seven months, with no news whatsoever from Synairgen, an update is by now long overdue. Hopefully, there will be no further excuses from our perennially disappointing CEO. GLALTIs.
Fruits - We have no idea what talks the company are involved in. Why? Because we haven't had an update since September!
To suggest I am burying my head in the sand is poor form. Please tell me what news I am ignoring?
Josh - no one makes you read the SNG board!
You 2 "tools" remain at liberty to bury your massive-brained heads in the sand if you wish.
The science and the current pandemic threat that shines a spotlight on the continued and urgent clinical need for viral agnostic treatments like SNG001 only serve to increase our chances of BP collaboration. The threat that is going to drive development of those drugs is increasing, not decreasing. But alas, tis not the news the cornpikes wish to hear....
Agreed Josh. Never anything that links us directly.
The cave door will have to be opened at some point.
Spac man raises an interesting point regarding funding and going concern.
All the tools on here, usual cut n paste crap, full of speculation as always, if your so confident buy up shares.
And just in case you missed it the first time;
"---> 3. critical for USG to accelerate development of host-targeted immune modulators to reduce/manage inflammatory cytokine storm in infected patients"
Which is exactly what SNG001 is - a host-targeted immune modulator to reduce/manage inflammatory cytokine storm in infected patients.
Sorry to blow a massive hole in your bonkers narrative about how SNG would be the last thing the scientific community would be calling for now, but that is EXACTLY what Rick Bright and others are calling for... - his tweet from yesterday;
"Detecting mutation in #H5N1 sequence from cow, associated w/ resistance neuraminidase inhibitor is significant concern; needs to be monitored very closely.
The US SNS for influenza antivirals is primarily NAIs. The specific mutation has been seen in this strain of H5N1 among birds. It's more assoc with resistance to zanamivir and peramivir; it may also reduce sens to oseltamivir. If this mutation spreads from cow to cow or to humans, it could mean we even fewer treatment options.
1. critical for USG to purchase more Xofluza/Baloxavir to diversify stockpile holdings (was needed even before current outbreak)
2. critical for USG to accelerate development of additional flu antivirals
---> 3. critical for USG to accelerate development of host-targeted immune modulators to reduce/manage inflammatory cytokine storm in infected patients
All urgently needed even if current nationwide outbreak in dairy cattle eventually subsides. H5N1 is not going away & these drugs are needed for seasonal flu, too."
No. 3 sounds unmistakeably SNG001. No. 2. potential also. Or perhaps you include the esteemed immunologist / virologist Rick Bright in your collective of "cornpikes", unworthy of scientific relevance.
Trying to persuade that SNG001 is of no relevance or interest as potentially we teeter on the edge of another pandemic, is just plain silly.
Hi Doc,
I certainly agree that in the doomsday scenario (absolutely one possibility) you describe the clamour will be for vaccines but they will also need effective antivirals. I don’t see stockpiling of an unlicensed therapeutic like SNG in advance but it will be trialed.
What I would love to see if/when there is another pandemic is the NHS and MRC really upping their game in scale of clinical trials. It can be done.
It would be devastating to see bodies piling up again without SNG at the centre of a large scale trial.
It's the same with everything American. Individual states make their own seperate laws based on all sorts of local circumstances or crazy prejudices and the Federal Govt treads a careful path through the middle. Only making Federal declarations in the most extreme circumstances to respect the semi independence of the Federal system. So when the FDA says don't drink raw milk, as it has done for decades, it's an advisory, unless it's important enough to make it a federal decree. 10m raw milk drinkers are told now that it may not be safe because of the threat of H5N1. How many of them listen is anyone's guess - but they'll most likely be the same freedom lovely hillybillies, chugging their milk straight from the teat as the anti-vaxing bumpkins who shuffled off in such prodigious numbers during the the pandemic. Everyone else will take heed and act according to commonsense and the scientific guidance and we'll all sit and watch the cornpokes heading for the exit door. The FDA will test and test again and destroy herds if necessary and stop the sale of raw milk countrywide if absolutely necessary and we'll hope that the early warning systems that Rick Bright acknowledges are working - are still doing their job. If they aren't and we find ourselves looking at a new pandemic with 50% fatality, they'll rush Mrna vaccines and monoclonals to the front line. The last thing anyone will be asking about or calling for, with cemeteries stacking them 6 deep - and at this stage of the drug's development - is SNG.
Https://x.com/rickabright/status/1784430949104537662?s=46&t=lUUs8mZ3DzN0LONpU_7P4w
This link describes vulnerability of NAIs eg oseltamivir to certain mutations of flu virus.
Another reason why host directed antivirals need development ie SNG.
Tommy, you seem to have changed your tune a bit from "news will be soon" two months ago? Yes, I got wind of the same "info" then, which simply confirms that certain members of the Synairgen BoD will say anything to appease in the moment (remember their promise to improve comms at the last AGM) or in the case of the CEO, abdicate responsibility and say absolutely nothing. All of it is pathetic.
However, they may be able to fool some of the people some of the time etc. but they need the accounts signing off within the next five weeks and BDO won't be so easily appeased over the Going Concern issue. Synairgen will have to say something soon.
Hopefully the recent organisational restructuring means a JV is in the offing.
GLALTHs
17 states permit raw milk sales on farms. Drinking or consuming raw milk is legal in all 50 states in the US. Raw milk is not pasteurised. Rick Bright's email in no way diminishes the risk H5N1 spreading via the food chain, as long as raw milk products from asymptomatic and diseased herds continues. The majority of animals in which H5N1 has been detected in recently in the US, have been asymptomatic.
If we get started with the trials shortly we might be able to help with an outbreak in say 4-5 years time.
In the meantime we are spectators opening 'my first science kit'
His subsequent tweet - posted 8 hours later - is more encouraging as he sees the preliminary FDA data released at last. Pasteurisation works - in milk and eggs. L:imited results so far but FDA promising more data soon from 297 samples from 38 states. Still just one human case.
https://twitter.com/RickABright/status/1784022075713151438
and this is the FDA update
https://www.fda.gov/food/alerts-advisories-safety-information/updates-highly-pathogenic-avian-influenza-hpai
The level of anxiety in USA now several notches higher after cats, cows and other mammals catching and many dying with highly pathogenic avian H5N1. I would suggest people read Rick Bright’s twitter feed. Some posters here may recall his support for SNG as important tool for host directed anti-viral.
https://x.com/rickabright/status/1783903851889959302?s=46&t=lUUs8mZ3DzN0LONpU_7P4w
An RNS is based on news not the time elapsed since the last one
When they have something to tell us we will get the RNS we all want.
Until then patience and a reality check on how long it takes to develop a drug trial, particularly one that’s so important to the company’s existence.
Come on Sir Stephen Holgate .
Come on Sir Stephen Holgate .
Do you know it's been 6 months since our last RNS, we must be due an annojncement.
Come on Dr .
The reality is trials and the science that backs them up takes a great deal of time to bring to fruition.
People got a false sense of urgency during COVID that things would happen within months. You could equally say that one of our biggest failures in Sprinter was rushing the trial design.
I remain patient knowing we will either get an update before H2 is ends or at the AGM. Our largest investor appears equally calm about the finances and our progress.