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Nice find. Brad Locar seems to be one of the most followed bio reporters does he not?
Good to see that Brad Loncar will be interviewing Lindy Durrant on his UK tour 'profiling the best of life sciences in London, Oxford, and Cambridge.'
https://twitter.com/BiotechTVHQ/status/1783797670462587120
I thought, would have at the vaccines we have pitched against in the other trials in the ASCO article find below
1.Evaxion Biotech 26th of April -4.1800
+0.0600 (+1.46%)
Day's Range 4.0500 - 4.2500
52 Week Range 2.8240 - 18.5000
https://www.evaxion-biotech.com
2. BioNtech https://www.biontech.com/int/en/home.html
Prev. Close 86.71
52 Wk. Low 85.21
52 Wk. High 125.83
3. Moderna https://www.modernatx.com/en-GB
Prev. Close 106.18
52 Wk. Low 62.55
52 Wk. High 142.79
4. Scancell https://www.scancell.co.uk
Prev. Close 9.60p
52 Wk. Low 7.59
52 Wk. High 18.29
5.IQ Biotech, Inc
https://iobiotech.com
Prev. Close 1.4500
52 Wk. Low 0.8160
52 Wk. High 2.6400
Sorry, last sentence should read "accountant"
Ripley,
Yes, in principle losses can be offset against gains as far as CGT liability goes,
There are a number of considerations though that can make the actual calculation complicated:
There are different rates of CGT for stocks and residential property. So offsetting one type against another will affect the tax liability.
There is CGT allowance and a personal tax allowance and both may come into play.
A capital gain is taxed when it is materialised so you can't offset paper losses!
Your account will be able to advise you on your particular circumstances.
Ripley
You'd have thought so but others here may know for certain.
Difficult decision whether to hold or sell. The obvious difficulty will be if you need access to the cash and can't sell but the upside is that C4X have great potential and strong leadership and I feel they may be biding their time waiting for conditions to improve for a NASDAQ IPO. If so that problem disappears.
Thanks again Bermudashorts
I have just kept my C4X the ones in the ISA were at the bigger loss , they will be transferd and held in the non ISA now.
As a side if they were ever to go bust , I wondered if you could offset against gains in ordinary acc .
First top up here for a wile that has not got even cheaper after 10 days .
Redmile Group, LLC
They still have a large holding in Scancell ( SCLP ) 29% which they increased by 12% 20/12/23 from previous 17%
RA Capital I read went on a Buying Spree over the last month , as did other hedge funds to a lesser extent in sector.
Yes Cleaner thanks for that. I'm not checking now but I thought that segment at ASCO included BioNTech, Moderna and Scancell. Therefore, so nice to see that special mention. ATB
Noted. I will ensure I spell out future comments very slowly for you.
Meanwhile, please feel free to pick on somebody else for your tedious nitpicking.
Nice find thanks for sharing
ASCO PUBLICATIONS
26th of April
“Curing Stage IV Melanoma: Where Have We Been and Where Are We?”
https://ascopubs.org/doi/10.1200/EDBK_438654
scroll down to Cancer Vaccines :
BioNTech (BNT221),57 while Moderna is focusing on the adjuvant melanoma space in collaboration with Merck.58 BioNTech is also the manufacturer of BNT111, a cancer vaccine encoding for a fixed set of four cancer-specific antigens (NY-ESO-1, MAGE-A3, tyrosinase, and TPTE),59 now being evaluated combined with cemiplimab in a randomized prospective trial that has recently completed recruitment (ClinicalTrials.gov identifier: NCT04526899).
Other innovative vaccine approaches in testing include Scancell's DNA plasmid vaccine, SCIB1, which incorporates specific epitopes from proteins gp100 and TRP-2, identified from the cloning of T cells from patients who spontaneously recovered from melanoma. Both proteins play key roles in the production of melanin. Evaluation of the first 12 patients recruited to a phase II trial combining SCIB1 with ipinivo reported a response rate of 83% (ClinicalTrials.gov identifier: NCT04079166). IO102-IO103, manufactured by IO Biotech, targets immunosuppressive proteins such as IDO and PD-L1. The phase I/II trial (KEYNOTE-D18) combined with pembrolizumab and demonstrated an overall response rate of 73% and a CR rate of 47%. These results led to the FDA granting breakthrough designation of the combination, and a confirmatory randomized phase II trial is underway (ClinicalTrials.gov identifier: NCT05280314).
Really? How can this sentence be read in any other way?
'If there was a 90% chance of exceeding an 85% ORR then you can be certain that 85% would have been the target ORR, not 70%.'
Perhaps 'without saying as much' part could be the problem?
They wouldn’t.
I was just making the point that the 90% confidence in reaching 70% is driven by the 85% already having been achieved in one cohort - and noting (without saying as much) that it would be nuts to think they had a 90% chance of beating 85%.
You seem determined to get the wrong end of the stick today……..
Ee
The whole trial was designed and powered to produce a 70% response rate as that is the level which demonstrates that SCIB1 is having an impact (ie. 20% higher than CPIs alone) and merits further development. How/why could/would they change that to 85%?
Johnny,
It is the fact that 85% is “in the bag” from the initial cohort that drives the 90% probability of exceeding 70% ORR.
If there was a 90% chance of exceeding an 85% ORR then you can be certain that 85% would have been the target ORR, not 70%.
That said, as I pointed out earlier, the 90% number is irrelevant once the results start coming in…..indeed their internal expectations may already be different?
Bermuda,
Thank you for getting clarification on that, I appreciate it.
Johnny,
Yes I know and it was your post (thanks) that prompted me to email as this seemed to contradict the original RNS which I understood to read 70% - see my post of 23rd. I think the wording of that part of the AGM presentation was unintentionally slightly ambiguous and could easily be interpreted as the probability of replicating the 85% response rate whereas they actually meant the probability of successfully passing the 70% threshold as the first cohort had done.
Anyway at least we know now. It will be really good news if they hit that 70% response rate which will mean the trial has been successful and a bonus if the response rate is higher.
So where are we estimating for next ‘actual news’ update? Hard to gauge where things are really at, at the moment which is another minor annoyance on top of the indifferent levels of clear communication from the BOD. Keep on holding, keep on hoping :)
Hi Bermuda (and emptyend),
I don't doubt what you are saying but that contradicts what Lindy said at the AGM and what it states on page 10 of the AGM presentation (See my 12.27 0n 23 April).
When you say "Lindy has clarified ............... ", have you emailed her?
Yes that is correct.
And, as someone pointed out earlier. the 90% probability figure is meaningless once the actual results start coming in. The actual results may be better or worse than implied by the high confidence figure.
Thanks for clearing that up Bermuda
Johnny,
Just an update on the 90% probability of success discussion regarding SCIB1.
Lindy has clarified that it is the probability of achieving a 70% response rate, not replicating the current 85%. To be precise it's the probability of achieving a '70% ORR on 43 patients' from the current SCIB1 study.
Cleanerworld
The NHS won't be paying for Modernal's vaccine - Moderna will be paying the NHS to run their clinical trials.
Good find WTP
the 26 th of April The good law project are questioning Sunak relationship with his fund Thelme and Moderna. A £400,000 Bespoke vaccine per patient ( as the times are now calling it ) a 10 year contract / tie in with the NHS is questionable ? belt and braces measure, after surgery . So how much is the total cost ? tIt’s a very interesting debate. Please read this link.
https://goodlawproject.org/government-ordered-to-disclose-sunaks-hedge-fund-emails/#:~:text=Shortly%20after%20Sunak%20became%20prime,a%20financial%20interest%20in%20Theleme.