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MrIndia do you think you will still be 50k down when they file IND? When they enter clinical trials? You clearly dont because your still here, they have not yet filed IND and are not yet clinical, anything that happens with the SP now has nothing to do with the science or CAR-T. Ignore the SP for now, we are not far from news (based on the FDA published guidelines for PreIND within 60 days) so really there is little point in worrying until news lands.
HereforHemo thats what I said, we are not "officially" IND stage, to the outside world we are Discovery/PreClinical HOWEVER those of us who follow the company know that in reality the pre clinical trials have been successfully completed. We are significantly de-risked in terms of moving into IND and Clinical trials. The next potential failure point realistically is Phase 1 trials.
Thats what makes Hemo a huge opportunity right now for those who can appreciate that whilst on paper we are not IND in reality we might as well be as the pre clinical testing is done, there is always a risk that the FDA will ask for additional tests, I dont think they will but they might.
In fairness, HE1 is up today!! Honestly, though, MrIndia you're in the wrong share if you're wanting immediate gains. Best to think of Hemo as a medium to long term investment. Patience is the order of the day. Don't stress the day-to-day gyrations otherwise your blood pressure will go through the roof, old thing. Keep calm, and go for long walks.
JHFH HEMO are not at the IND stage hence why no one is buying it yet. When they submit an IND application they will be at the IND stage, could be weeks away but it could be months away. Time will tell.
So GDR and NNN are not down a huge amount since you bought them lol.
why dont you get a new hobby rather than worrying about my shares ...and no others are not down. This is absolutely the worst stock i have with over 50k down currently and Its been a long wait to get any reversal. I am slowly faith with all these people selling into any rises
Looking at the other shares you own mrdepressing , they are all well down, you need to stick to premium bonds!
Also, surely the use of our humanized mice in development of candidates must improve % chance of success.
did u miss me hemo truth?
Oh God he is back !!
Its gonna go red and i dont get it anymore ... just seen 40k worth of sells go through .... this is so depressing
Nicely written JHFH.........Roll on the FDA meeting, even though I'm positive, I just want to hear the results soon. A RNS progress either this week or next I'll be very happy with.
It's nice to see it just turn blue, it's not much of a rise, but at least we are blue
Have to be honest dhub I am disappointed in the SP but not surprised given the trading behaviour of late, nor am I disheartened because despite the increased interest here on LSE there is little mention of Hemogenyx further afield (Google it, zero relevant hits). I found ~500 active CAR-T clinical trials going on world wide and below that thousands of new treatments in development not yet at that stage. If someone like Eli Lilly, Kite, Novartis or Celgene was taking HEMO-CAR-T forward it would be getting a lot of attention but Hemogenyx is not on any radar. Today it is a speculative investment deemed too high risk for many and due to the low mCap many funds cannot even consider making an investment here yet.
I would consider HEMO-CAR-T to be at IND stage however its not official yet, I dont view the Pre-IND meeting as a risk but more an opportunity for fast track and last minute check with the FDA. The figures differ significantly depending on field and source but a rough ball park on failure rates is worth looking at:
Discovery and Lead selection - Approx 50% of candidates fail at this point
Pre Clinical - Approx 30% fail here
IND - This is a transition gap where it moves from Pre-Clinical to Clinical, This is where Hemogenyx is, there is no testing or failure rate it just is not official yet.
Phase 1 - 30+% fail here
Phase 2 - ~50%
Phase 3 - ~30%
Today Hemogenyx is Pre-Clinical, to the rest of the world except for the fact a load of us are shouting and screaming they are about to go clinical nobody is listening, there is nothing official that makes Hemogenyx any different from the thousands of other pre-clinicals out there of which 50% + 30% will fail at this stage before IND and who may be years from IND application. The FDA are the ones who make Hemo "clinical" and rubber stamp the work done to date. Having seen now how slow pharma is I am not surprised many wait for the IND before investing!
The industry attaches a steep discount at each stage due to the likelihood of failure and we are still in that Discovery/Pre Clinical band. Even though there is a significant chance of failure in Phase 1 entering that Phase significantly increases the likely hood of progressing to Phase 2 and has a significant reduction on the discount offered.
I have been one of the most vocal about Hemo both here and twitter but you reach a point where you realise the people we want to invest are not listening, but they will listen to the FDA. Pre CLNS we were valued at 50-60mil+ and today its? 16mil? We are a year further on with the risk of dilution removed(it happened already) and the risk of pre-clinical testing failure pretty much behind us. I wont say what the SP would be but I seriously cannot see Hemogenyx staying below an mCap of 150-250mil when they start clinical trials, something I expect in the coming months. There is a certain amount of faith that the FDA will rubber stamp everything but I take comfort in the fact that Penn and Wu-Xi etc a
Agreed, this should move up today. I'm just surprised it hasn't yet!!!
Another item of good news today that will benefit mankind and HEMO are on the same path.
I think the time has come for the re-rate to begin.