Roundtable Discussion; The Future of Mineral Sands. Watch the video here.
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- Carl clearly knows the mhra required settings , so, I expect sensitivity and specificity near enough 97-99% range.
Speed of test for first stage is probably around 5mins. Speed of second test is probably under 30secs.
- I agree , with your statement saying avacta are a bit behind.
- Genedrive have announced a 15min test after having £9m funding and seven months research. The value of the company is £65m and have no sales in PCR.
- Paraytecs 2 stage " transformer," test is fairly unique in that it is lft test and poc test at the same time.
- I expect manufacturing and marketing partners to be announced within 2-3 months for Paraytec . If not, it is in TBs probable interest to sell this company to a larger diagnostic company, (£50-60m?)
Kainos, interesting comment from Carl!
What I do know (as a shareholder in Avacta):
1. MHRA Guidelines
Acceptable Sens > 80%, Spec > 95%
Desired Sens > 97%, Spec > 99%
https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/895745/TPP_Point_of_Care_SARS-CoV-2_Detection_Tests.pdf
2.Sona Nanotech initially declared for their LFT a externally validated sensitivity of 96% and specificity of 96%. Reasonable performance against MHRA guidelines. However, during clinical evaluation of their LFT, the figures dropped to 84.6% for sensitivity and 90% for specificity!
https://investingnews.com/daily/life-science-investing/biotech-investing/sona-nanotech-announces-clinical-evaluation-study-results-for-its-covid-19-antigen-test/
In simple terms, wrt MHRA Guidelines, not good enough!!
3. Avacta promised a LFT mid Summer. To date, NO sensitivity and NO specificity information has been officially released. NO in-house,
NO independent and NO clinical validation sensitivity and specificity data has been released. Why?? Someone, claiming to be a former employee at Avacta, stated on the AVCT BB, that manufacture of a LFT is difficult. The slightest Production variation causes a marked change in Sensitivity and Specificity performance outcome of the test! Is this the reason, Avacta have deferred release until Q1 2021? Who knows? (Probably the MMs - LOL!!!)? However, a delay is a delay and Q1 2021 just happens to be when Carl's test is available for roll-out!
4. Avacta's CEO (Dr AS) has stated that no one Company has the capacity to supply the covid test demand. Hence, my statements on this BB that no one supplier will have a monopoly. Essentially, all good tests are needed.
However, some tests will inherently have better clinical performance.
Carl's test is very fast (tick), sensitive (tick) and specific (tick). Listen to the Proactive interview:
https://m.youtube.com/watch?v=-M0O-JFoFUc
Carl's background, tells me he knows his stuff! He is not some Aim CEO wanting your money!!
In Carl we trust, was a title of one of the threads on this BB. Well, for me the POC outcome and my investment was always binary. So I am willing to become a LTH!
"Trust in the force" springs to mind. If everything works out we have a multi bagger here based on market cap.
Worth being a LTH in BRH?? Absolutely!!
Hold for gold!
DYOR!
Carl's test - Speed (tick), Sensitivity (tick), Specificity (tick)
Test, test, test
Kainos, Better ask Pro Smythe himself
1509, on twitter ,when Pro Smythe was asked which was the better test between Paraytecs and Avactas, Carl subsequently said there would need to be clinical trials to determine which one. Sounds very much like the tests are similar but with ours having a few extra advantages .
Kainos
This was an interesting interview - Prof Smythe
https://www.youtube.com/watch?v=-M0O-JFoFUc
6H
Thanks - do you think the Prof earlier work on protein phosphorylation - might have led to the breakthrough in detection this week?
Light / wavelengths / bound to a protein - gives a signal (Not unlike modern astronomy looking at stars) - Not had a drop of vino - school night :)
Phosphorylation - phospherous - like tracer bullets - forgive me - I am not a scientist - but intrigued in this story.
Seems logical?
Professor Carl Smythe
Department of Biomedical Science
Professor of Cell Biology
c.g.w.smythe@sheffield.ac.uk
+44 114 222 4643
E03a Florey Building, Firth Court
Full contact details
Professor Carl Smythe
Department of Biomedical Science
E03a Florey Building
Firth Court
Western Bank
Sheffield
S10 2TN
Profile
2002 – present: Professor of Cell Biology, Department of Biomedical Science, University of Sheffield
2004 – 2006: Head of Department, Department of Biomedical Science, University of Sheffield
1992 – 2002: Principal Investigator at MRC Protein Phosphorylation Unit, University of Dundee
1989 – 1992: American Cancer Society Senior Research Fellow, University of California, San Diego
1985 – 1989: British Diabetic Association postdoctoral research assistant at MRC Protein Phosphorylation Group at University of Dundee
1981 – 1985: PhD Department of Biochemistry, Trinity College, University of Dublin
Aptamers and affimers work in quite similar ways. In this case both will bind only to an intact virus protein spike . With paraytec , the difference here is that nanoflourescent particles bind to an intact virus and will show up on their specific machine . Under the light detection they are able to see these particles and detect concentration levels , i.e. state of infection.
In fact, Avacta and Paraytec are quite similar. They both own all IP , both work with universities and both are working on next gen testing. The UK government is only handing out £100m contracts contracts per company initially and Avacta are a few months ahead , but the market cap £10m v £450m is substantial.
Lol jodrell.....’the mm’s know there is bad news coming’ you do know that would be illegal before shareholders are alerted; get real and just accept this as market fluctuations.
Evening All
Anyone here got any good pointers for research - I get "Aptamers" are the original peptide molecules for binding to nasties - and "Affimers" are like second generation -I note Para use Apatamers and have all IP after developing own in - house - good move IMO
In the presentation Prof Smythe getting very animated when asked about other pathogens etc as discussed by 6H - (Thanks for replies) - so Para can develop further Aptamers for eg bacterial and larger zoonotic infections?
I still am quite flabbergasted after again digging round the usual Google searches / news / new scientist and Uni blogs - no mention if this breakthrough tech after proof of concept which should be generating a lot of interest in these "unprecedented times" ... (Hate that expression - but it works).
Anyway - can anyone expand further on the history or help with the technical side of the breakthrough?
Any good websites / tweets (Im rubbish at that) or self research notes etc.?
Would be appreciated.
Cheers and GL