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Thank you Sad, exciting times ahead indeed. And Dr Parker likes the word indeed too-
' SDC-1801 does indeed downregulate the increase in cytokines believed to be responsible for ARDS and the cytokine storm following infection with SARS-CoV-2'.
SOG. Love the calcs. Remdesivir is my comparator. Looks like 5 days at $500 per pill. https://www.forbes.com/sites/jvchamary/2021/01/31/remdesivir-covid-coronavirus/
Nice workings and thought process SOG
It is strange that Tim confirmed the manufacturing route for SDC-1801 was all done but that SDC-1802 was still being worked on, I would have thought the manufacturing route would be the same for both compounds?? Even possibly the same organisation?
Gunner. In a sense you are correct. They would not be mass producing now as not required. However, should mass production be required I feel sareum have this avenue covered.
There will be a lot going on behind the scenes that we are not privvy too.
Hundreds of milligrammes? At a treatment dose for example 5mg per day over 28 days is 140mg for 100,000 persons ie
0.02 % approx UK population. Equates to 14000000 mg or 14000 grammes or even 1.4kg. That i feel would be absolute minimum amount required for UK government contingency plan.
Maximimum worldwide of that lowest of doses at modest 1% of 7billion would be 70 million now 70 million multiplied by 140 mg = 7x 10 to the power of 7 multiplied by 140 milligrammes, equates to 70,000,000 x140 = 9,800,000,000 mg.
milligrammes to grammes divide by a thousand is 9, 800,000 grammes divide by a thousand again will give 9,800 kilo or 9.8 tonnes.
check my figures as done in my head. Check modest dosing regime and 28 day treatment period ( may be half that ie 14 days) not taking into account of course here a therapeutic treatment.
Put a price on SDC1801 worth.
This is taking that trials are successful, no better performing alternative or indeed any alternative treatment found and world wide availability. taking of course only 1% of people world wide will develop cytokine storm.
9.8 tonnes of a pharmaceutical compound worth more than an equivalent mass than diamonds. Dose price dependant of course. Just some idea of the potential that you cannot rule out.
Apologies if this article has already been posted. I was drawn to the final 2 paragraphs, in particular: "The taskforce, modelled on the team responsible for the UK’s vaccine programme, is aiming to identify and support research into promising antiviral treatments that can reduce transmission and speed up recovery from Covid-19.
It’s hoped two effective treatments – offered in tablet form – will be made available to the public as early as autumn, providing Britain with “another layer of defence” alongside the vaccines in combating possible future waves and emerging variants, said Sir Patrick Vallance in April." Does anyone know what these two treatments are?
I’m sure they mentioned being able to produce hundreds of mg s of 1801 already or even grams so if that’s the case they would be stockpiling this already
Ahfam. the secret patent as I see it would refer to their crystallisation of compounds.
Sareum already have patents for their compounds of groups 00, 01 and 02.
Secondly on this point the crystallisation of compounds has many benefits, the main one being a solution to solubility issues. This resolves any problems that may be encountered in the production and manufacture of a compound to be taken through the oral route.
Then we have compounds that we put into phase 1 trials. We have SDC 1801 and SDC 1802. In effect two differing candidates with respective differences.
if a 3rd compound were made this would need to go through the same preclinical trials as per 1801 and 1902 and this surely cannot be the case as notification of a new candidate for the treatment of Covid would have been announced.
I can also find no reason why a new candidate for auto immune would be required for Covid 19. Our Tyk 2 Jak1 looks extremely promising in the targets it hits. I am firmly of the opinion that it is, not that we require to modify ( hence new candidate) in any shape our compound to achieve success in treating Covid 19. but rather all the requirements that our necessary to treat covid are already there.
To summarise then, it is not a case of finding a treatment specifically for Covid 19, but it just happens that Covid is a very suitable target for our Tyk2 Jak 1 inhibitor.
Only problems we have encountered and that was with our Aurora FLT plus 3 solubility issues and with ore 1801 being able to produce greater than research amounts of our compound. In this case potential mass production. Remember the difficulty that sareum experienced trying to establish maximum tolerated dose ( that were for for testing MTD in murine). Tims words we are looking at new ways to formulate the compound to make sufficient for MTD testing and for use in trials. This was from memory March April last year.
That problem I believe has now been overcome. The patent grant will follow (take approx a year to 18 months fom early last year). If you look in depth with our Tyk 2 patent there is a reference to crystallisation of compounds around November 2020. Not refer to sareum but if not applicable to us why is it then cited.
All looks fine here. price may dip slightly and if does will add considerably.
Regards and all the best to you
I mentioned a few weeks back when I had a stab at a news drop date that IMHO it is inconceivable that SAR have not been in high level strategic planning meetings with government reps from UKRI, AGILE, Antivirals Taskforce and the cabinet office scientists.
Ever since Boris made his announcement of a covid pill by Autumn (coincidentally 1 day before Parker’s tweet (Major Development) and 2 days before our ‘delayed for no reason’ half year results - which I believe were delayed to get data from UKRI to the cabinet office) the government spin doctors and speech writers would have been controlling this world changing news.
Don’t forget I specifically raised a question at the meet the investors event about UKRI reporting and did they know about our progress. John responded ‘live and unscripted’ that a UKRI had witnessed regularly the progress and had reported back.
Since then IMHO the back rooms of Whitehall have been extremely busy strategically planning the next steps and designing clinical trials with SAR. They would be securing production, logistics and storage for a massive rollout. Legal teams would have been drafting agreements between all stakeholders.
All will be revealed soon. Boris will be centre stage hailing UK Scientists and Sareum.
Ahfam just imagine if the new patent is for Covid, and results of the study are good. Share price could double immediately !
ahfam - also using the word 'encouraging' in relation to the research...
Afham / lazarus stop it you’re getting me excited! Hehe!
I think I've mentioned before that I used to work with scientists ... As a breed of individuals they never seem to get excited over much. They are also often conservative in their claims often down playing the results of their work ... The "muffled" enthusiasm shown by our scientists would equate to an excited squeal elsewhere ... What I am trying to say is they have found something very big and soon the world will know about it ... We all just need to continue to be patient ... I could care less what the share price does at the moment ... Because we all know where it will go soon.
Additionally now that we closer to the 6 months research ending we have had they following statements-
Investor meet- Dr Reader saying 'the world will hear about it in due course' in regards to a question about the patent.
Tweet- Dr Parker saying 'Major Developement and success would be good for the UK and World'
A day after half yearly RNS- Dr Parker saying '1801 does indeed downregulate cytokine storm'
Dr Mitchell saying 'if it continues to be successful'
Subtle hints or confidence they know AGILE is in the bag and have government support.
Can’t disagree ahfam.
The fact that it is so secretive aligns with John’s comment about the world will know all about it soon or words to that effect. Interesting and exciting times.
Sareum - healing the world
Baton, Lazarus, I know I keep going on about it- but I do really believe that the secret patent is for covid.
I reckon last March when they submitted the application for the secret patent I think they knew already that it would work hence why they refused to elaborate in the investor meet last year saying it was confidential and they needed to protect the IP but then very shortly after they announced that they had applied for the covid grant.
That's an excellent point Lazarus, they are bound to have been making future plans. If they know what they have, then that must be a given.
I am still of the opinion that we are further advanced with our Covid trial than has been suggested. This will move forwards very quickly. Once progressed, there will need to be a lot of commercial contingency planning to complete, not to mention partnering. Nobody in their right mind will wait for the final day before making plans. Expect the news releases to ramp up very shortly
Thoth absolutely ... I saw nothing on that list that compares to what we have. ... And all of them have tox/efficacy issues. Our wait can't be long now. I can imagine our bod are batting pharmaceutical suitors away like flies at the moment. Something has to give. Either we will get a cash or partnership offer we cannot refuse. I feel we are close now.
You can only assume a packet of those pills would be in 99% households world wide!!
Mafuta. Thx for the bbc therapeutics link. Some additional comments. Monoclonal antibodies block a hospital bed and a nurse for a day. Its intravenous and needs supervision during and 4 hours after.
Remdesivir thats mentioned. And WHO says is innefective per article. Is still forcast to generate sales of $6bn this year at a 30% margin. Imagine what an effective therapeutic thats a pill to take at home would sell.