George Frangeskides, Chairman at ALBA, explains why the Pilbara Lithium option ‘was too good to miss’. Watch the video here.
London South East prides itself on its community spirit, and in order to keep the chat section problem free, we ask all members to follow these simple rules. In these rules, we refer to ourselves as "we", "us", "our". The user of the website is referred to as "you" and "your".
By posting on our share chat boards you are agreeing to the following:
The IP address of all posts is recorded to aid in enforcing these conditions. As a user you agree to any information you have entered being stored in a database. You agree that we have the right to remove, edit, move or close any topic or board at any time should we see fit. You agree that we have the right to remove any post without notice. You agree that we have the right to suspend your account without notice.
Please note some users may not behave properly and may post content that is misleading, untrue or offensive.
It is not possible for us to fully monitor all content all of the time but where we have actually received notice of any content that is potentially misleading, untrue, offensive, unlawful, infringes third party rights or is potentially in breach of these terms and conditions, then we will review such content, decide whether to remove it from this website and act accordingly.
Premium Members are members that have a premium subscription with London South East. You can subscribe here.
London South East does not endorse such members, and posts should not be construed as advice and represent the opinions of the authors, not those of London South East Ltd, or its affiliates.
For years cancer vaccines were considered a no go area. so this exposure is a great thing as we obviously think ours is better and universal, cheaper and currently with better results subject to expansion of trial.
Perhaps this may be the nudge needed for a bid approach 🤔 🙏
Ee
I apologise if I should have understood that from your post but it wasn't obvious to me because SCIB1 has never been trialled in this setting - ie. in combination with PD-1 CPI in the adjuvant setting. So how can you compare at this stage?
Keytruda is approved as an adjuvant therapy in melanoma and the Moderna trial was a randomised study with Ketruda alone as the control arm versus Keytruda plus the Moderna Vax. So the 49% figure is the reduction in the risk of recurrence/death when taking the combination versus treatment with Keytruda alone.
That is the whole point of my last sentence - if the phase III study is successful it validates the combination setting for cancer vaccines.
Bermuda,
It should have been totally obvious to you that I was drawing a comparison with SCIB1 and its potential effectiveness. 🙄
Plainly if “the only game in town” offers some smallimprovement, you would take it.
Bermuda,
I thought the same when I read the post - I'd jump at the chance of a 44% better chance of survival. (The figure in the daily mail article)
I'm not sure this halves the chances.we'd need to know the figure it's an improvement on.
Ee
Seriously? Think if I was about to face surgery to have melanoma removed but was told I was in the very high risk category of it returning and someone offered me a vax which halved the chances of recurrence I'd jump at it. Credit where credit is due.
Success of any cancer vaccine is great news for Scancell but as 2cvguy mentioned earlier, this is particularly important as it establishes the utility of cancer vaccines in combination with checkpoint inhibitors.
As mentioned earlier in the week by Bermuda
A DNA plasmid melanoma cancer vaccine, SCIB1, combined with nivolumab + ipilimumab in patients with advanced unresectable melanoma: Efficacy and safety results from the open-label phase 2 SCOPE trial.
article
Abstract
Authors
Heather Shaw
Heather Shaw
Mount Vernon Cancer Center
Heather Shaw, Poulam Patel, Miranda Payne, Satish Kumar, Sarah Danson, Martin Highley, Kellati Prasad, Ruth Board, Clare Barlow, James Larkin, Kate Young, Amanda Fitzpatrick, Ioannis Karydis, Maria Marples, Rebecca Lee, Philippa Corrie, Robert Miller, Georgia Goodhew, Fayaz Master, Lindy Durrant
Organizations
Mount Vernon Cancer Center, Nottingham University Hospitals NHS Trust, Churchill Hospital, Velindre Cancer Centre, Weston Park Cancer Centre, Sheffield Teaching Hospitals NHS Trust & University of Sheffield, Derriford Hospital, Lancashire University Hospital, Lancashire Teaching Hospitals NHS Trust, Musgrove Park Hospital, Somerset Foundation Trust, The Royal Marsden Hospital NHS Foundation Trust, Royal Marsden Hospital NHS Foundation Trust, Guy’s & St Thomas’ NHS Foundation Trust, University Hospital Southampton NHS Trust, St. James's University Hospital, The Christie NHS Foundation Trust, Cambridge University Hospitals NHS Foundation Trust, Scancell Ltd
Thanks C11,
Just to add that both may prove to have further utility and each will plough it's own furrow so to speak. It is important to remember the development opportunities that may arise from these types of platform. There-in lays the real value me thinks. But first lets get iSCIB1+ validated!
Bermuda, thanks for your reply to my concern!
This is the lead story in The Daily Telegraph today. A 49% improvement doesn’t sound enough for a personalised vaccine to me. Lets hope that one of the reasons for Scancell’s recent quiet period in RNSs is that they are preparing a blockbuster update - together with attendant front page publicity!
Violindog,
Sorry, missed your post. Don't worry, the Moderna clinical trial won't have any impact on recruitment to the SCIB1 trial because it's in a different setting and recruiting from a different patient population. Moderna's trial is in the adjuvant setting - patients who have had their tumours surgically removed and are vaccinated to prevent recurrence whereas Scancell's trial is recruiting patients with advanced inoperable melanoma with tumour in situ.
C11 agree with your point room for more than one type of cancer vaccine Heather Shaw referred to “ these will be game changers in immunology “
See Bermuda post on ASCO earlier in the week . Also heather shaw in on the advisory board for the Scope Trial
Skin cancer jab trial targets high-risk melanomas
https://www.thetimes.co.uk/article/e23343c5-91c4-49b0-9fa4-c1eec5c2bb2c?shareToken=6d03ef8920e19e9d3d4fd5f793fc9d06
Dr Heather Shaw, consultant medical oncologist and the national co-ordinating investigator for the trial, said: “I think there is a real hope that these will be the gamechangers in immunotherapy.”
Each patient has their own personalised jab manufactured within weeks, using mRNA genetic code found in their tumours. When injected, the jab instructs the body to create proteins identical to those found on the surface of tumours, triggering an immune response.
From Bermuda shorts
Really good to see that Heather Shaw, one of the SCIB1 study investigators will be presenting a poster at ASCO in Chicago in June.
SCIB1 & iSCIB1+ - Scancell
The abstract title:-
A DNA plasmid melanoma cancer vaccine, SCIB1, combined with nivolumab + ipilimumab in patients with advanced unresectable melanoma: Efficacy and safety results from the open-label phase 2 SCOPE trial.
Presenter: Heather May Shaw, MD, FRCP, MRCP | Mount Vernon Cancer Center
Abstract: 9535
| Poster Bd #: 319
ASCO isn't just another scientific conference, it's the largest oncology conference in the world and it would have been disappointing if Scancell were not represented.
Chelsea
Absolutely spot on.
IMO, it won’t be a case of either MRNA, or DNA as an available treatment option and there will be room for both as ammo against melanoma. In the same way that there are often multiple treatment options for other diseases. Assuming of course that trial data proves they both work well.
The publicity is positive on a number of fronts. Scancell now need to get their own data published. We already know that should be this year and we’re already in April, so it’s just a handful of months away.
Explains why recruitment has been a little slow....Moderna will be first in the queue!
I like the way the BBC website article has the quote 'you couldn't give this to the next patient in the line because you wouldn't expect it to work.
"It's truly personalised."'
Makes it.sound like an advantage rather than a drawback. If Scancell vaccines come along as hoped, imagine the quotes available for them - ' off the shelf', 'universal' etc.
Just have to wait and see.
I see the story is headline news in some newspapers and contained in that story is Dr Heather Shaw, national co-ordinating investigator for the trial.
Https://www.bbc.co.uk/news/health-68897731
Can't say I was aware of this trial before, and I note it is a Phase 3 trial so earlier phases were apparently more under the radar (for me anyway).
I see some positives from this story:
- the combination with Pembro and Keytruda is validated
- results from this trial (49% improvement) will provide a comparison to SCIB1
- this is a personalised (expensive) treatment.
Hopefully we'll get this kind of front page coverage one day.
A clip from nanaco “moditope has passed phase 1 and is showing positive signs”
Is this for real ? No wonder big Pharma don’t show any sign of interest
Violin, Sadly only telling It as I see It. Who and Why the consistent selling?. Unfortunately topped up at the last dilution. Fortunately Not a lot. Last placing @ 11P today's SP 9.50P IMO.
Good find Cleaner. I see that this relates to the partnership with Vaccitech announced 7 November’22. I wonder if we will have a Phase 1 study this year:-
https://www.lse.co.uk/rns/SCLP/licenses-vaccitech-technology-to-advance-modi-2-5arpm4twcqxzkuu.html
Prof Lindy Durrant, Chief Executive Officer, Scancell, commented: "We are pleased to partner with Vaccitech to take the second candidate from our Moditope® platform through GMP and subsequent clinical development. With its elegant and effective solution, the SNAPvax™ technology provides an excellent method for formulation of the Modi-2 vaccine. Combining this technology with our expertise will allow us to develop a rapid manufacturing process for Modi-2, with the hope that we can bring it into a Phase 1 clinical study during 2024."
If no value why pay $200m ? It seems scan is good in posters and repeating ample times the same message.
Burn cash and next round of dilution will be lower than the 11p. If concrete then give up some info if not stop promoting a dream by claiming encouraging promising exciting and the rest of wishful thinking outcome. And please take if hope and other BS descriptive words from future communication
wednesday 7 th of august 11:25 am
modi-2, a vaccine targeting ****citrullinated self-epitopes, stimulates potent cd4-mediated anti-tumor responses as a therapy for solid cancers
https://www.immuno-oncologysummit.com/cancer-vaccines?utm_source=linkedin&utm_medium=social&utm_campaign=vjm_final_track_agenda_20240423
abdullah al-omari, phd, scientist, t cell vaccine, scancell ltd.
stresses within the tumor microenvironment mediate post-translational modifications of self-proteins. ****citrullination is the conversion of lysine residues to ****citrulline which can generate neoepitopes and bypass self-tolerance. modi2, a ****citrullinated peptide-snapvax vaccine, stimulates strong th1 responses and anti-tumor immunity in three different murine tumor models. we propose the modi-2 vaccine formulation has potential for translation into clinic in several cancer indications.
Drac, you are correct re the sales..as for Redmile...whatever raises the SP...nothing else is achieving this, even after the numerous conferences.
A whiff of desperation (i.e. ill thought out comments ) in quite a few posts of late IMO.
Interesting.