Notifiable Interest

10 Oct 2007 15:31

Proteome Sciences PLC ("the Company") Notifiable Interest

A form TR-1 containing the following information has been received by the Company.

TR-1 notification of major interests in shares

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:

Proteome Sciences PLC

2. Reason for the notification

An acquisition or disposal of voting rights

3. Full name of person(s) subject to the notification obligation:

MF Global UK Limited

4. Full name of shareholder(s) (if different from 3):

N/A

5. Date of the transaction (and date on which the threshold is crossed or reached if different):

09/10/07

6. Date on which issuer notified:

10/10/07

7. Threshold(s) that is/are crossed or reached:

7

8. Notified details: 7.16

A: Voting rights attached to shares

Class/type Situation previous Resulting situation after the triggering of shares to Triggering transaction transaction if possible Notification required under DTR transitional using ISIN provision 7 CODE Number of Number of Number of Number of % of Shares Voting shares voting rights voting rights Rights Direct Direct Indirect Direct Indirect GB0003104196 8,179,247 8,179,247 9,411,408 9,411,408 9,411,408

B: Financial Instruments

Resulting situation after the triggering transaction Type of Expiration Exercise/ Number of voting rights that may % of financial date Conversion be acquired if the instrument is voting instrument Period/ Date exercised/ converted rights Total (A+B)Number of voting rights % of voting rights 9,411,408 7.16%

9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable:

N/A 10. Name of the Proxy holder:N/A

11. Number of voting rights proxy holder will cease to hold:

N/A

12. Date on which proxy holder will cease to hold voting rights:

N/A13. Additional information:N/A14. Contact name:15. Contact email address:Tr1@mfglobal.com