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8 Nov 2022 12:05
Syncona Limited
Achilles reports Q3 2022 Financial Results and Business Highlights
08 November 2022
Syncona Ltd, a leading healthcare company focused on founding, building and funding a portfolio of global leaders in life science, notes that its portfolio company, Achilles Therapeutics Plc (Nasdaq: ACHL) ("Achilles"), announced its financial results for the third quarter ended September 30, 2022, and an update on recent business highlights.
The announcement can be accessed on Achilles' website at: https://ir.achillestx.com/ and the full text of the announcement from Achilles is contained below.
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About Syncona
Syncona's purpose is to invest to extend and enhance human life. We do this by founding and building a portfolio of global leaders in life science to deliver transformational treatments to patients in areas of high unmet need.
Our strategy is to found, build and fund companies around exceptional science to create a diversified portfolio of 15-20 globally leading healthcare businesses for the benefit of all our stakeholders. We focus on developing treatments for patients by working in close partnership with world-class academic founders and management teams. Our balance sheet underpins our strategy enabling us to take a long-term view as we look to improve the lives of patients with no or poor treatment options, build sustainable life science companies and deliver strong risk-adjusted returns to shareholders.
Achilles Therapeutics Reports Third Quarter 2022 Financial Results and Recent Business Highlights
- Interim update from the ongoing Phase I/IIa trials in advanced NSCLC (CHIRON) and melanoma (THETIS) to be presented at the ESMO Immuno-Oncology Annual Congress 2022 -
- Strong cash balance of $179.9 million supports all planned operations into Q2 2025 -
London, November 8, 2022 - Achilles Therapeutics plc (NASDAQ: ACHL), a clinical-stage biopharmaceutical company developing AI-powered precision T cell therapies to treat solid tumors, today announced its financial results for the third quarter ended September 30, 2022, and recent business highlights.
"This quarter we continued to advance our clinical programs and look forward to providing an update from our ongoing Phase I/IIa CHIRON and THETIS clinical trials in non-small cell lung cancer (NSCLC) and melanoma, respectively, at the ESMO Immuno-Oncology Annual Congress," said Dr Iraj Ali, Chief Executive Officer of Achilles Therapeutics. "A poster entitled 'Early Proof of Concept of Safety and Clinical Activity of Clonal Neoantigen Reactive T Cells,' will be presented and available from December 6, 2022. We expect additional clinical data readouts across our programs throughout 2023 which, along with our strong cash balance, position Achilles well for the future."
Financial Highlights
· Cash and cash equivalents: Cash and cash equivalents were $179.9 million as of September 30, 2022, as compared to $266.3 million as of December 31, 2021. The impact of translating our books and records from British Pounds Sterling into U.S. dollars had an unfavorable impact on the reported balance cash and cash equivalents. The net decrease reflects an underlying use of $45.7 million for operating and investing activities and a negative $40.7 million foreign exchange impact. The Company anticipates that its cash and cash equivalents are sufficient to fund its planned operations into the second quarter of 2025, including completion of the ongoing Phase I/IIa CHIRON and THETIS clinical trials.
· Research and development (R&D) expenses: R&D expenses were $10.6 million for the third quarter ended September 30, 2022, as compared to $10.7 million for the third quarter ended September 30, 2021.
· General and administrative (G&A) expenses: G&A expenses were $5.4 million for the third quarter ended September 30, 2022, as compared to $5.0 million for the third quarter ended September 30, 2021. The increase was primarily driven by an increase in personnel costs.
· Net loss: Net loss for the third quarter ended September 30, 2022, was $12.5 million or $0.32 per share compared to $12.9 million, or $0.34 per share for the third quarter ended September 30, 2021.
Upcoming Events
Achilles will participate in the following investor and medical conferences. Additional details will be available in the Events & Presentations section of the Company's website:
· Jefferies London Healthcare Conference: November 15 - 17, 2022
· TIDES Europe - Oligonucleotide & Peptide Therapeutics: November 16 - 18, 2022
· Piper Sandler Annual Healthcare Conference: November 29 - December 1, 2022
· ESMO Immuno-Oncology Congress 2022: December 7 - 9, 2022
· J.P. Morgan Annual Healthcare Conference: January 9 - 12, 2023
About Achilles Therapeutics
Achilles is a clinical-stage biopharmaceutical company developing AI-powered precision T cell therapies targeting clonal neoantigens: protein markers unique to the individual that are expressed on the surface of every cancer cell. The Company has two ongoing Phase I/IIa trials, the CHIRON trial in patients with advanced non-small cell lung cancer (NSCLC) and the THETIS trial in patients with recurrent or metastatic melanoma. Achilles uses DNA sequencing data from each patient, together with its proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient, and then develops precision T cell-based product candidates specifically targeting those clonal neoantigens.
Forward-Looking Statements
This press release contains express or implied forward-looking statements that are based on our management's belief and assumptions and on information currently available to our management. Although we believe that the expectations reflected in these forward-looking statements are reasonable, these statements relate to future events or our future operational or financial performance, and involve known and unknown risks, uncertainties and other factors that may cause our actual results, performance, or achievements to be materially different from any future results, performance or achievements expressed or implied by these forward-looking statements. The forward-looking statements in this press release represent our views as of the date of this press release. We anticipate that subsequent events and developments will cause our views to change. However, while we may elect to update these forward-looking statements at some point in the future, we have no current intention of doing so except to the extent required by applicable law. You should therefore not rely on these forward-looking statements as representing our views as of any date subsequent to the date of this press release.
Investors:
Achilles TherapeuticsLee M. Stern, VP, IR & External Communicationsl.stern@achillestx.comLifeSci AdvisorsJohn Mullalyjmullaly@lifesciadvisors.com
Media:Consilium Strategic CommunicationsMary-Jane Elliott, Sukaina Virji, Melissa Gardiner+44 (0) 203 709 5000achillestx@consilium-comms.com
ACHILLES THERAPEUTICS PLC
Condensed Consolidated Balance Sheets (Unaudited)
(in thousands, except share and per share amounts)
(expressed in U.S. Dollars, unless otherwise stated)
September 30, |
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| December 31, |
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|
| 2022 |
|
| 2021 |
| ||
ASSETS |
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Current assets: | ||||||||
Cash and cash equivalents | $ | 179,890 | $ | 266,319 | ||||
Prepaid expenses and other current assets | 18,797 | 18,430 | ||||||
Total current assets | 198,687 | 284,749 | ||||||
Non-current assets: | ||||||||
Property and equipment, net | 17,419 | 17,743 | ||||||
Operating lease right of use assets | 8,472 | 11,048 | ||||||
Deferred tax assets | 26 | 26 | ||||||
Restricted cash | 33 | 33 | ||||||
Other assets | 2,713 | 3,507 | ||||||
Total non-current assets | 28,663 | 32,357 | ||||||
TOTAL ASSETS | $ | 227,350 | $ | 317,106 | ||||
LIABILITIES AND SHAREHOLDERS' EQUITY |
| |||||||
Current liabilities: | ||||||||
Accounts payable | $ | 7,516 | $ | 3,722 | ||||
Income taxes payable | 59 | - | ||||||
Accrued expenses and other liabilities | 7,445 | 10,906 | ||||||
Operating lease liabilities-current | 4,036 | 4,482 | ||||||
Total current liabilities | 19,056 | 19,110 | ||||||
Non-current liabilities: | ||||||||
Operating lease liabilities-non-current | 4,952 | 7,777 | ||||||
Other long-term liability | 726 | 691 | ||||||
Total non-current liabilities | 5,678 | 8,468 | ||||||
Total liabilities | 24,734 | 27,578 | ||||||
Commitments and contingencies (Note 12) | ||||||||
Shareholders' equity: | ||||||||
Ordinary shares, £0.001 par value; 40,938,763 and 40,603,489 shares authorized, issued and outstanding at September 30, 2022 and December 31, 2021, respectively | 54 | 54 | ||||||
Deferred shares, £92,451.851 par value, one share authorized, issued and outstanding at September 30, 2022 and December 31, 2021 | 128 | 128 | ||||||
Additional paid in capital | 407,155 | 401,821 | ||||||
Accumulated other comprehensive (loss) income | (38,490 | ) | 6,636 | |||||
Accumulated deficit | (166,231 | ) | (119,111 | ) | ||||
Total shareholders' equity | 202,616 | 289,528 | ||||||
TOTAL LIABILITIES AND SHAREHOLDERS' EQUITY |
| $ | 227,350 | $ | 317,106 | |||
ACHILLES THERAPEUTICS PLC
Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited)
(in thousands, except share and per share amounts)
|
| Three Months Ended September 30, |
|
| Nine Months Ended September 30, |
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| 2022 |
|
| 2021 |
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| 2022 |
|
| 2021 |
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OPERATING EXPENSES: |
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Research and development | $ | 10,597 | $ | 10,697 | $ | 38,387 | $ | 30,417 | ||||||||
General and administrative | 5,437 | 5,041 | 17,162 | 15,318 | ||||||||||||
Total operating expenses | 16,034 | 15,738 | 55,549 | 45,735 | ||||||||||||
Loss from operations | (16,034 | ) | (15,738 | ) | (55,549 | ) | (45,735 | ) | ||||||||
OTHER INCOME, NET: |
| |||||||||||||||
Other income | 3,599 | 2,806 | 8,499 | 2,907 | ||||||||||||
Total other income, net | 3,599 | 2,806 | 8,499 | 2,907 | ||||||||||||
Loss before provision for income taxes | (12,435 | ) | (12,932 | ) | (47,050 | ) | (42,828 | ) | ||||||||
Provision for income taxes | (41 | ) | (16 | ) | (70 | ) | (41 | ) | ||||||||
Net loss | (12,476 | ) | (12,948 | ) | (47,120 | ) | (42,869 | ) | ||||||||
Other comprehensive income: | ||||||||||||||||
Foreign exchange translation adjustment | (18,147 | ) | (7,710 | ) | (45,126 | ) | (6,572 | ) | ||||||||
Comprehensive loss | $ | (30,623 | ) | $ | (20,658 | ) | $ | (92,246 | ) | $ | (49,441 | ) | ||||
Net loss per share attributable to ordinary shareholders-basic and diluted | $ | (0.32 | ) | $ | (0.34 | ) | $ | (1.20 | ) | $ | (1.69 | ) | ||||
Weighted average ordinary shares outstanding-basic and diluted | 39,313,764 | 38,261,480 | 39,104,866 | 25,329,672 | ||||||||||||