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3 Jun 2008 07:00
Physiomics plc
The Magdalen Centre
The Oxford Science ParkRobert Robinson AvenueOxford
OX4 4GAUK
Tel 01865 784980
Fax 08701 671931
03 June 2008
Physiomics plc ("Physiomics" or "the Company")
Physiomics to present on Chronotherapy at the Beyond Genome Conference
More information about the conference may be found at www.beyondgenome.com
For further information:
Physiomics plc +44 (0)1865 784980
Dr Christophe Chassagnole, COO
E-mail: cchassagnole@physiomics-plc.com
About TEMPO project (LSHG-CT-2006-037543)
In 2006 Physiomics has been selected to participate in the TEMPO Project as one of four Industry partners working closely with four distinguished European academic research groups. The project is coordinated by INSERM unit director Prof Francis Levi, at Paul Brousse hospital in Villejuif (France). TEMPO is a STREP project funded in part by the European Commission through its Life Sciences and Health Sixth Framework programme.
This three year programme is exploring the effect of circadian rhythms (the body's clock) on changes in cell proliferation and the effectiveness of cancer drugs and will use this knowledge to optimise treatment. The aim is to optimise treatment of individual patients taking into account the 24h rhythms generated by the patient's biological clock. Physiomics is using its cell simulation technologies to study the effect of cancer drugs on the cell cycle/circadian clock system behaviour, at the cellular level, the cell population level (virtual Fluorescence-Activated Cell-Sorting experiment) or tissue level (virtual tumour). Using pharmacokinetics simulation in connection with pharmacodynamics profile, Physiomics will help establish one or more physiological relevant drug regimes and delivery schedules.
Physiomics will receive approximately £169,000 (€252,650) of matched funding over the three year period and if successful will share in 3 to 5 new therapeutic schedules according to the patient profiles for 2 main drug classes against cancer and more specifically colorectal cancer. TEMPO develops tools that will enable to select the best administration schedule for anti-cancer drugs, taking into account the genes expression profile of the patient. Under temporal control of the drug administration, the efficacy as well as the toxicity will be controlled in an optimised manner.
For further information, please visit www.chrono-tempo.org
About Physiomics plc
Physiomics develops computational systems biology models to predict and understand cancer drug efficacy from pre-clinical research to clinical development. Physiomics has created detailed mathematical models incorporating most important molecular events taking place during the human cell cycle and apoptosis processes. Physiomics developed SystemCell® technology, a multi-cellular environment software, which enables the simulation of population of "virtual cells".
Physiomics, based in Oxford, UK, was founded in 2001, and floated on AIM in 2004. For further information, please visit www.physiomics-plc.com
SystemCell® is a registered trademark of Physiomics plc
1Tufts Centre Impact Report 2002
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