Proteome Regulatory News (PRM)

6 Sep 2007 16:27

Proteome Sciences Plc ("the Company") Notifiable Interest

A form TR-1 containing the following information has been received by the Company.

TR-1 notification of major interests in shares

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:

Proteome Sciences Plc

2. Reason for the notification

An acquisition or disposal of voting rights

3. Full name of person(s) subject to the notification obligation:

MF Global UK Limited

4. Full name of shareholder(s) (if different from 3):

N/A

5. Date of the transaction (and date on which the threshold is crossed or reached if different):

4 September 2007

6. Date on which issuer notified:

5 September 2007

7. Threshold(s) that is/are crossed or reached:

7%

8. Notified details:

A: Voting rights attached to shares

Class/type Situation previous to Resulting situation after the triggering

of shares Triggering transaction transaction if possible Notification required under DTR transitionalusing ISIN provision 7 CODE Number of Number of Number of Number of voting % of voting Shares Voting shares rights rights Rights Direct Direct Indirect Direct Indirect

GB0003104196 9,505,805 9,505,805 8,179,247 8,179,247 N/A 6.22 N/A

B: Financial Instruments

Resulting situation after the triggering transaction Type of Expiration Exercise/ Number of voting rights that may % of financial date Conversion be acquired if the instrument is voting instrument Period/ Date exercised/ converted rights N/A N/A N/A N/A N/A Total (A+B)

Number of voting rights % of voting rights

8,179,247 6.22%

9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable:

N/A10. Name of the Proxy holder:N/A

11. Number of voting rights proxy holder will cease to hold:

N/A

12. Date on which proxy holder will cease to hold voting rights:

N/A13. Additional information:N/A14. Contact name:N/A15. Contact:N/A