Proteome Regulatory News (PRM)

10 May 2007 17:03

Proteome Science PLC ("the Company") Notifiable Interest

A form TR-1 containing the following information has been received by the Company.

TR-1 notification of major interests in shares

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:

Proteome Science PLC

2. Reason for the notification

Acquistion or disposal of voting rights

3. Full name of person(s) subject to the notification obligation:

Fidelity International Limited (FIL)

4. Full name of shareholder(s) (if different from 3):

See attached schedule

5. Date of the transaction (and date on which the threshold is crossed or reached if different):

8 May 2007

6. Date on which issuer notified:

10 May 2007

7. Threshold(s) that is/are crossed or reached:

5%

8. Notified details:

A: Voting rights attached to shares

Class/type of Situation previous Resulting situation after the triggering shares to Triggering transaction transaction if possible Notification required under DTR transitionalusing ISIN provision 7 CODE Number of Number of Number Number of voting % of voting Shares Voting of rights rights Rights shares Direct Direct Indirect Direct Indirect ISIN 6,679,879 6,679,879 3,844,823 2.93% GB0003104196 B: Financial InstrumentsResulting situation after the triggering transaction Type of Expiration Exercise/ Number of voting % of voting financial date Conversion rights that may rights instrument Period/ Date be acquired if the instrument is exercised/ converted Total (A+B)Number of voting rights % of voting rights 3,844,823 2.93%

9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable:

Management Company Shares Held Nominee FISL 1,626,368 JP Morgan, Bournemouth (Fidelity Investment Services Ltd) FIL 1,349,412 JP Morgan, Bournemouth (Fidelity International Ltd) FIL 869,043 Brown Bros Harrimn Ltd Lux (Fidelity International Ltd)

10. Name of the Proxy holder:

Fidelity International Limited (FIL)

11. Number of voting rights proxy holder will cease to hold:

2,835,056

12. Date on which proxy holder will cease to hold voting rights:

8 May 2007

13. Additional information:

14. Contact name - James Malthouse

15. Contact number - 01932 865065