INS.L Regulatory News (INS)

8 May 2012

Instem plc

("Instem", the "Company" or the "Group")

Posting of Annual Report and Accounts

Notice of Annual General Meeting

Total Voting Rights

Instem plc (AIM: INS.L), a leading provider of IT applications to the global early development healthcare market, announces that on 27 April 2012, it posted to shareholders its Annual Report and Accounts for the year ended 31 December 2011, together with the Notice of the Annual General Meeting to be held at 12.00 noon on Tuesday 22 May, 2012 at the offices of Baker Tilly UK Audit LLP, 3 Hardman Street, Manchester M3 3HF.

Copies of the Annual Report and Accounts are available on Instem's website at: http://investors.instem.com/.

The Company's issued share capital consists of 11,764,658 ordinary shares with a nominal value of 10p each ('Ordinary Shares'). This figure reflects a discrepancy of 1 Ordinary Share against the figure previously stated. Application has been made to the London Stock Exchange for the additional 1 new Ordinary Share, which ranks pari passu with existing Ordinary Shares, to be admitted to trading on AIM as soon as is practicable.

The Company does not hold any Ordinary Shares in Treasury and each Ordinary Share carries one voting right. Therefore, the total number of voting rights in the Company is 11,764,658.

The figure of 11,764,658 may be used by shareholders as the denominator for calculations by which they will determine if they are required to notify their interest in, or a change to their interest in, the Company under the FSA's Disclosure and Transparency Rules.

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