ETX.L Regulatory News (ETX)

e-Therapeutics plc ("e-Therapeutics" or the "Company")

14 March 2012

Notification of Transactions of Directors, Persons Discharging Managerial Responsibility or Connected Persons

The Company was informed on 13 March 2012 that, on that day, Oliver James, Non- executive Chairman, purchased 34,500 ordinary shares in the Company at 29.0p per share.

Professor James's resultant total holding is 98,000 ordinary shares representing 0.1% of the issued share capital of the Company which currently stands at 138,126,467 shares all carrying voting rights.

Contacts

e-Therapeutics plc Tel: +44 (0)79 0991 5068

Daniel Elger

Panmure Gordon (UK) Limited Tel: +44 (0)20 7459 3600

Andrew Burnett/ Fred Walsh