Aptitude Regulatory News (APTD)

21 March 2013

Microgen plc (the "Company")

Annual Information Update

In accordance with Prospectus Rule 5.2, the Company sets out below its Annual Information Update relating to information which has been published or made available to the public up to and including 21 March 2013.

1. Regulatory Announcements

The following UK regulatory announcements have been issued through PRN or RNS, both Regulatory Information Services. They can be viewed or downloaded from the London Stock Exchange Web Site (www.londonstockexchange.com) in the Market News section, searching under the Company's code MCGN.

Date Regulatory Headline and Detail

21-Mar-13 Directors Shareholdings

21-Mar-13 PDMR Shareholding

08-Mar-13 Posting of Annual Report and Notice of AGM

25-Feb-13 Preliminary Results

19-Feb-13 Notice of Results

04-Jan-13 Blocklisting Interim Review

30-Nov-12 Total Voting Rights

12-Nov-12 Interim Management Statement

31-Oct-12 Total Voting Rights

23-Oct-12 Holding(s) in Company

28-Sept-12 Blocklisting Interim Review

31-Aug-12 Total Voting Rights

31-Jul-12 Total Voting Rights

26-Jul-12 Transaction in Own Shares

25-Jul-12 Transaction in Own Shares

23-Jul-12 Interim Results

13-Jul-12 Notice of Results

04-Jul-12 Blocklisting Interim Review

02-Jul-12 Total Voting Rights

30-Apr-12 Total Voting Rights

24-Apr-12 Directorate Change

24-Apr-12 Result of AGM

24-Apr-12 Interim Management Statement

02-Apr-12 Blocklisting Interim Review

30-Mar-12 Total Voting Rights

26-Mar-12 Director/PDMR Shareholding

20-Mar-12 Annual Information Update

2. Documents filed at Companies House

The Company filed the following documents at Companies House on or around the dates indicated.

Date Document Type

19-Mar-13 AA Annual Accounts made up to 31 December 2012

14-Nov-12 SH01 Return of Allotment of Shares

04-Oct-12 SH06 Notice of Cancellation of Shares

04-Oct-12 SH03 Return of Purchase of Own Shares

29-Aug-12 SH01 Return of Allotment of Shares

03-Aug-12 SH07 Notice of Cancellation of Shares

05-Jul-12 SH01 Return of Allotment of Shares

09-May-12 AR01 Annual Return made up to 12 April 2012

27-Apr-12 RES10 Authorised Allotment of Shares and Debentures

27-Apr-12 RES13 Amendment to the Rules of the VERBS

27-Apr-12 RES09 Authority to Purchase Shares Out of Capital

27-Apr-12 RES11 Disapplication of Pre-emption Rights

26-Apr-12 TM01 Termination of Director Appointment Mr Paul Davies

26-Apr-12 TM01 Termination of Director Appointment Mr Ralph Kanter

25-Apr-12 SH01 Return of Allotment of Shares

05-Apr-12 CH01 Director's Change of Particulars Mr Philip Wood

Copies of the documents filed at Companies House can be obtained from Companies House website at www.companieshouse.gov.uk or Companies House, Crown Way, Cardiff, CF14 3UZ.

3. Documents sent to Shareholders

The following documents have been published by the Company and sent to the Company's shareholders and were submitted to the UK Listing Authority's Viewing Facility on the dates listed below.

A copy of this Annual Information Update and all documents referred to in it can be obtained from the Group's registered office:

Microgen plc

Old Change House

128 Queen Victoria Street

London

EC4V 4BJ

This Annual Information Update is required by, and is being made pursuant to, Article 10 of the Prospectus Directive as implemented in the UK by Prospectus Rule 5.2 and not for any other purpose. Information is referred to in this update rather than included in full. The information referred to was up to date at the time it was published; however, some information may now be out of date. Neither the Company, nor any other person, takes any responsibility for, or makes any representation (express or implied) as to the accuracy or completeness of the information.

For further information, please contact:

A. O'Neill, Company Secretary 020 7496 8100